Anti-estrogen kwayoyi: description, aikace-aikace

Estrogen-blockers ne sinadaran mahadi da cewa toshe mataki na estrogen. Antiestrogen kwayoyi amfani da magani na cututtuka daban-daban. Suna yadu amfani domin lura da ciwon daji na nono matakai don hana ƙari girma ko cutar ta koma dawowa rigakafin. Kamar yadda shi ne yanayin da sauran kwayoyi da hulɗa tare da hormones a cikin jiki, wadannan kwayoyi ya kamata a yi amfani da ƙarƙashin likita dubawa.

Amfanin da kuma illolin da estrogen

Estrogen, ko wani steroid hormone hada da farko ta ovaries. Ana rinjayar da dama matakai na jiki. Mata na haihuwa da matakin qarshe na halitta hormone. An wuce kima adadin, duk da haka, na iya haifar da wani ciwo da aka sani da hyperestrogenia. Wannan cuta na iya haifar da cutar daji tsari a cikin nono da kuma endometrial ciwon daji. Anti-estrogen kwayoyi da kuma estrogen blockers da aromatase hanawa iya shi gyara kome. Wadannan kwayoyi, duk da haka, da kyau da kuma mummunan tasirin a kan mata da maza.

Iri estrogen-blockers da su yi amfani da

Akwai da dama iri-iri na estrogen-blockers. aromatase hanawa zahiri toshe samar da estrogen. Zababben estrogen tsoka mai amsa sigina modulators, kamar "Tamoxifen" "Clomiphene", tsara don toshe estrogen rabe, da kuma nuna hali daban domin daban-daban na masana'anta. Antiestrogens kuma toshe estrogen rabe.

Antiestrogens hana hira da testosterone zuwa estradiol da estrogen hormones gushe aiki ko katange.

A ciwon daji magani, wadannan kwayoyi suna amfani da su rage gudu da ci gaban siffofin maruran. A wannan yanayin, zabe estrogen tsoka mai amsa sigina modulators za a iya niyya ga takamaiman estrogen rabe. Blockers, ciki har da "Clomiphene" aka kuma wani lokacin amfani da magani na rashin haihuwa, da suka iya taimaka wasu matan da suka yi wahala da zama ciki. Wadannan kwayoyi suna kuma amfani da wasu clinicians a lura da yara da jinkiri mafarki har su girma su isa.

Daga cikin Bodybuilders shi sanya amfani da estrogen-blockers saboda estrogenic sakamako na high matakan da testosterone a cikin jiki. Testosterone ne precursor na wani estrogen, aromatase hanawa za a iya amfani da su dakatar da samuwar tsoka taro wuce haddi na estrogen, rike wani low matakin a cikin jiki. Wannan aiki ya janyo hankalin mutane da yawa, musamman a lokacin da anti-estrogen kwayoyi suna amfani da farko don kwaskwarima dalilai. A wannan yanayin, mutane suna ta amfani da Allunan, kuma ya sinadirai masu kari ba tare da likita dubawa.

illa

Akwai gefen sakamakon anti-estrogen kwayoyi. Sun iya sa dizziness, ciwon kai, sweating, zafi filasha da kuma rikice. Kawai endocrinologist iya sanin da ya dace sashi don wani haƙuri dangane da halin da ake ciki, da kuma wani m dokin illa. A endocrinologist iya rubũta yau da kullum da jini gwaje-gwaje domin hormone matakan lokacin da kimantawa da sauran harkokin kiwon lafiya na haƙuri tabbatar da cewa yin amfani da anti-estrogens da hadari da kuma aikin ga mãsu haƙuri.

maza magani

Tare da shekaru, namiji testosterone matakan sauke. Duk da haka, idan testosterone aka sauri ko ƙwarai rage, shi zai kai ga ci gaban da hypogonadism. Wannan jiha ne halin da jiki ta rashin iyawa, don samar da wannan muhimmanci hormone, zai iya sa wani iri-iri na bayyanar cututtuka, ciki har da:

• asarar libido.
• akan rage samar da ingancin maniyyi.
• erectile tabarbarewa.
• gajiya.

Idan muka magana game da estrogen, abu na farko da mutane zaton cewa shi ne mace hormone, amma da kasancewar tabbatar da cewa namiji jiki ne su aiki sosai. Akwai iri uku estrogens: estriol, estrone da estradiol. Estradiol - shi ne babban nau'i na aiki estrogen a cikin maza. Yana taka rawar gani a rike da aiki na namiji gidajen abinci da kuma kwakwalwa nama. Antiestrogen kwayoyi kuma damar da maniyyi zuwa ga ci gaba yadda ya kamata.

Hormonal rashin daidaituwa - kiwon da matakin na estrogen da kuma rage testosterone - halitta matsaloli. Da yawa estrogen a namiji jiki iya kai wa ga:

• gynecomastia (wuce kima ci gaban da nono nama).
• zuciya da jijiyoyin jini matsaloli.
• ƙãra hadarin wani bugun jini.
• nauyi riba.
• Matsaloli tare da prostate.

Za ka iya yi da dama matakai don mayar da ma'auni a matakin estrogen. Alal misali, idan ka wuce haddi estrogen ake dangantawa da low matakan da testosterone, cewa zai iya zama da amfani a matsayin testosterone maye far na estrogen shafi.

Pharmaceutical estrogen-blockers

Wasu pharmaceutical kayayyakin iya nuna estrogen-tarewa sakamako a maza. Matsayin mai mulkin, mafi sau da yawa suna nufin amfani da mata, amma ana samun in shahararsa a tsakanin mutane, musamman wadanda suke so da yara. Testosterone kari na iya haifar da rashin haihuwa. Amma estrogen blockers kamar "Clomid" iya mayar da hormonal auna ba tare da compromising haihuwa.

Da dama kwayoyi da aka sani da zabe estrogen tsoka mai amsa sigina modulators, yawanci kasuwanci a matsayin kwayoyi domin lura da nono. Amma su kuma za a iya amfani don toshe estrogen a cikin maza. Wadannan kwayoyi suna amfani da dama yanayi alaka low testosterone, ciki har da:

• rashin haihuwa.
• low maniyyi count.
• gynecomastia.
• osteoporosis.

Wadannan kwayoyi dole ne a yi amfani da selectively, dangane da mãsu haƙuri. Amfani da irin wannan zanga-estrogen kwayoyi. A cikin kantin magani za ka iya saya:

• "Tamoxifen".
• 'Arimidex'.
• "Letrozole."
• "Raloxifene".

Gurbin kan kashi

A cewar clinicians, shafe tsawon daukan hotuna zuwa estrogen kwayoyi na iya haifar da ciwon daji endometrial a mata. "Raloxifene" - a zabe estrogen tsoka mai amsa sigina modulator - zai iya hana ci gaban ciwon daji, selectively tubalan sha na estrogen. Wannan magani, duk da haka, shi ne ma iya inhibiting da tabbatacce sakamakon estrogen a kan kashi yawa. A sabon maganin - "lasofoxifene" - iya gyara wannan matsala. Yana hana asarar kashi yawa a postmenopausal mata da kuma rage brittleness na kashi nama. A amfani da wannan magani ne kullum hadari, amma na iya kara jini clots.

miyagun ƙwayoyi interactions

Estrogen shafi "Tamoxifen" iya taimakawa wajen hana ciwon daji. Ciwon daji marasa lafiya sau da yawa fuskanci ciki, kuma wannan rukuni na kwayoyi iya mu'amala barnatar da magunguna, antidepressants. Ya kamata tambaya "Paroxetine", saboda gaskiyar cewa mata shan "Tamoxifen" da "Paroxetine", kasa hadarin mutuwa fiye da matan da suka yi "Tamoxifen" da kuma wani antidepressant. Wannan shi ne saboda "Paroxetine" abubuwa selectively.

Antiestrogen jamiái da kwayoyi

A disclosures na duk wadannan kudi nuna cewa kowane magani da ake amfani da daidaiku a wani batu.

"Clomid" ko "clomiphene citrate" yana daya daga cikin asali kwayoyi amfani da magani daga gynecomastia, saboda shi kiwata jiki ta matakin na halitta testosterone. Akwai wasu illa daga dogon lokacin da amfani, kamar wahayin da matsaloli. Akwai karin tasiri abubuwa a kasuwa, wanda aiki a wannan hanyar, amma "Clomid" shi ne har yanzu tasiri da kuma m mix ga wani dan wasa.

Wannan ba wani anabolic steroid, wani magani fiye wajabta a matsayin agaji a mata tare da haihuwa, saboda shi yana da pronounced ikon ta da ovulation, wanda aka samu da tarewa / minimizing da sakamakon estrogen a cikin jiki. Don zama takamaimai, "Clomid" - sinadaran Properties na roba estrogen agonist / antagonist. A wasu manufa tsokoki shi iya toshe ikon da estrogen su ɗaure a daidai tsoka mai amsa sigina. Its asibiti amfani ne counter korau feedback daga estrogen a hypothalamus-pituitary-ovarian tsarin, wanda bunkasa saki LH da FSH. Duk wannan take kaiwa zuwa ovulation.

Domin wasa dalilai "clomiphene citrate" mata da wani sakamako. A maza, duk da haka, akwai aka ƙara samar da FSH kuma (musamman) luteinizing hormone cewa stimulates halitta testosterone. Wannan sakamako ne musamman m ga dan wasa a karshen wani steroid sake zagayowar lokacin da na ciki testosterone matakan da ake tawayar. Ba tare da testosterone (ko wasu androgens), "Cortisol" Bayyana kuma rinjayar gina jiki kira a tsoka. Amma ya sauri "ci" mafiya yawa daga cikin sabon samu tsoka bayan sakewa. Clomid iya taka muhimmiyar rawa a hana wannan gazawar cimma wasanni sakamakon. Ga mata, amfanin mataki Clomid - Ability don sarrafa na ciki estrogen matakin. Wannan zai kara da asarar mai da tsoka, musamman a yankuna, irin na cinyoyinsa da gindi. "Clomiphene citrate", duk da haka, sau da yawa samar illa a mata, amma, duk da haka, bukatar tsakanin wannan rukuni na 'yan wasa.

"Tamoxifen" tarewa estrogen rabe a nono Kwayoyin. Wannan tsaya a nan estrogen daga mu'amala da su da kuma hana ci gaban da kuma division na sel. Duk da yake "Tamoxifen" abubuwa a matsayin wani antiestrogen a mammary gland shine yake Kwayoyin, shi abubuwa kamar an estrogen a wasu kyallen takarda: kashi da mahaifa.

Mata tare da dogara da nono "Tamoxifen" masu cin zali ciwon daji za a iya amfani da shi don 5-10 shekaru bayan da aiki, don rage da alama na metastasis watsa. Yana kuma rage hadarin da bunkasa ciwon daji a cikin wasu nono. Domin da wuri mataki na wannan shiri da aka yi amfani da farko don marasa lafiya da suke yi ba menopause. Aromatase hanawa ne fi so magani ga menopausal mata.

"Tamoxifen" iya dakatar da ci gaban ko ƙyama marurai a marasa lafiya tare da metastatic ciwon daji marasa lafiya. Yana kuma iya iya amfani da su rage hadarin tasowa nono onkologicheskihz tafiyar matakai.

Wannan magani an dauka baki, yawanci a cikin nau'i na alluna.

Illa na anti-estrogen kwayoyi hada da gajiya, zafi filasha, ta farji rashin ruwa ko copious da kuma yanayi swings.

Wasu mata da metastases a kashi nama na iya faruwa zafi da kumburi a cikin tsokoki da kuma kasusuwa. Wannan yawanci ba šauki tsawon, sai a wasu rare lokuta, mata iya ci gaba high matakan da alli a cikin jini, wanda aka ba prokontroliruesh. Idan wannan ya auku, to, magani za a iya dakatar don wani lokaci.

Rare, amma mafi tsanani illa ma zai yiwu. Wadannan kwayoyi na iya kara hadarin tasowa ciwon daji na myometrium a mata da menopause. Karuwan jini clotting ne wani yiwu tsanani illa. Deep jannayẽnsa thrombosis ya auku, amma wani lokacin da wani yanki na jini gudan jini iya karya tafi da kuma ƙarshe toshe jijiya a cikin huhu (na huhu embolism).

Wuya "Tamoxifen" ne dalilin shanyewar jiki da kuma zuciya hare-hare a postmenopausal mata.

Dangane da menopausal matsayin mata "Tamoxifen" iya samun daban-daban effects a kan kashi. A premenopausal mata, "Tamoxifen" zai iya sa thinning na kasũsuwa, ashe, amma a post-menopausal mata qara matakin da alli, wajibi ne ga kashi ƙarfi.

Amfanin wannan magani outweigh da kasada domin kusan duk mata da hormone-dogara cin zali nono.

Hakazalika, miyagun ƙwayoyi ne "Toremifene", wanda aka amince domin lura da metastatic nono. Duk da haka, wannan magani zai yi aiki ba idan amfani da "Tamoxifen", amma ba tare da sakamako.

"Fulvestrant" ne mai magani cewa tubalan farko estrogen tsoka mai amsa sigina, sa'an nan kuma ta kawar da tsoka mai amsa sigina nauyin iya aiki. Yana abubuwa a matsayin wani anti-estrogen a ko'ina cikin jiki.

"Fulvestrant" da aka amfani da su bi a guje metastatic nono, kuma mafi sau da yawa amfani bayan sauran hormonal kwayoyi ( "Tamoxifen" da kuma aromatase hanawa) wanda tsaya aiki.

Common illa iya hada zafi filasha, rika zufa da dare, m tashin zuciya da kuma gajiya. Rubuce, zai iya raunana ƙasũsuwa (osteoporosis), idan dauka na dogon lokaci.

Wannan magani ya lashe fitarwa don amfani a postmenopausal mata suke ba su karɓa wa "Tamoxifen" ko "Toremifene." An wani lokacin amfani ga manufar da aka nufa in premenopausal mata, sau da yawa a hade tare da wani luteinizing hormone-sakewa agonist don kashe ovaries.

"Raloxifene" amfani da mata domin yin rigakafi da magani daga kashi hasãra ko osteoporosis bayan menopause. Ya taimaka wajen kula da karfi ƙasũsuwa, rage hadarin samu karaya.

"Raloxifene" kuma iya hana abin da ya faru na cin zali nono bayan menopause. Ya ba da estrogen hormone, amma abubuwa kamar estrogen a wasu sassa na jiki, kamar kashi. A wasu sassa na jiki (nono da kuma mahaifa), "Raloxifene" abubuwa a matsayin wani estrogen shafi. Ya ba canja wani iri-iri menopausal ciwo. Raloxifene da dangantaka da wani aji na kwayoyi da aka sani da zabe estrogen tsoka mai amsa sigina modulators-SERMs (estrogenic da antiestrogenic kwayoyi).

Anti-estrogen kwayoyi da kuma Sports

Wasu kwayoyi suna amfani da ko'ina a Bodybuilders gina tsoka.

"Cyclofenil" - shi ne neanabolichesky / Androgenic steroid. Yana aiki a matsayin anti-estrogen da testosterone a matsayin stimulant. "Cyclofenil" ne mai matukar rauni, kuma m estrogen, amma shi ta ɗaure estrogen rabe da kuma hana dauri na halitta estrogen rabe. A gaskiya, shi yana aiki sosai da wasu 'yan wasa sama da miyagun ƙwayoyi a lokacin wani steroid magani domin ya kula low matakan estrogen. A sakamakon - rage adadin ruwa a jiki, wanda aka halitta da steroids da kuma raguwa a gynecomastia. A dan wasa yana da wani m waje, ta amfani da irin wannan kwayoyi, wanda zai iya yiwuwar za a dauka a lokacin shiri domin a gasar. Bodybuilders, duk da haka, yi amfani da shi m sau da yawa saboda su fi son karin araha 'Nolvadex' da kuma 'Proviron. "

Kamar "Clomid", "Cyclofenil" shi ne m, a mata, kamar yadda yana da kyau tasiri ne kawai a kan samar da hormones a cikin maza. Kiwon da matakin na testosterone lalacewa ta hanyar wannan miyagun ƙwayoyi ne bai isa ya yi magana game da m inganta, amma shi zai samar da ikon riba, ko da karamin karuwa a jikin nauyi, wani gagarumin karuwa a samar da makamashi da kuma wani karuwa a farfadowa yiwu. Wadannan sakamakon su gani musamman a ci-gaba da 'yan wasa da suke da kadan, ko kuma ba tare da kwarewa steroids. Yi amfani da sakamakon da ya zama a bayyane ne kawai bayan wani mako.

A wasu lokuta, 'yan wasa suna kallon eruptions kamar kuraje, ta ƙara jima'i drive da zafi flushes. Wadannan cututtuka su ne musamman nuni shaida cewa fili shi ne ainihin tasiri. Bayan an daina wasu ruwaito tawayar yanayi da kuma wani kadan karu a jiki ƙarfi. Waɗanda suka riƙi da miyagun ƙwayoyi a matsayin anti-estrogen a lokacin steroid magani, zai iya tsayar da kishiyar sakamako a lokacin da sakamakon da wakili da aka tsaya.

"Proviron" shi ne daya daga cikin tsofaffin anabolic Androgenic steroids a kasuwa. Hukumance da aka sani da "Mesterolone", shi ya kasance daya daga cikin mafi unclaimed tsakanin anabolic steroid masu amfani.

A wani aikin akai Proviron yana hudu main ayyuka, wanda sun fi mayar da sanin da hanya na aiki. Da farko, shi ne daya daga cikin mafi iko anabolic steroids, saboda shi qara adadin zagawa da free testosterone, wanda shi ne mafi muhimmanci a gare anabolic matakai Bodybuilders. A sauki hanyar dubi da shi: idan kana shan anabolic steroids, da tsoka taro na karuwa ne.

"Proviron®" Har ila yau yana da ikon hulɗa tare da enzyme aromatase, wanda shi ne alhakin da hira da testosterone zuwa estrogen. By dauri ga aromatase, "Proviron®" iya zahiri hana ta aiki, ta haka ne samar da kariya daga illa na estrogen.

A "Mesterolone" ma yana da karfi da dangantaka da androgen tsoka mai amsa sigina. Wannan anabolic steroid cewa ba kashe gonadotropins ne kama da sauran anabolic steroids. Wannan ya sa ya yiwu don kara samar da maniyyi, kazalika da androgens ne na wajibi ga ruri daga spermatogenesis. Wannan ba kawai ƙara yawan maniyyi, amma kuma inganta da inganci.

Gefen Gurbin "Proviron" Ba hada gynecomastia ko wuce haddi da ruwa. Wannan zai har muhimmanci rage hadarin cutar hawan jini hade tare da shan anabolic steroids. A gaskiya, "Proviron" yana da anti-estrogenic sakamako da tsayawa da hira da testosterone zuwa estrogen, ko a kalla rage gudu wannan tsari.

A muka ambata a sama kwayoyi ba runtse da estrogen matakin amma shafar metabolism a general.

A rukuni na antiestrogenic kwayoyi kuma sun hada da agonists sakewa dalilai gonadotropic hormones ( "Buserelin" da kuma ta analogs), megestrol acetate ( "Megeys") "Parlodel" da "Dostinex" ana amfani da kwayoyi, dakatar da prolactin mugunya. Nasu amfani da magani daga wadanda ba m.

Jiyya na ciwon daji

Bugu da kari to "Tamoxifen" Wadannan estrogen tsoka mai amsa sigina blockers.

Uku da kwayoyi da cewa dakatar estrogen samarwa a postmenopausal mata, an amince da su bi duka biyu farkon da kuma ci-gaba da nono: "Letrozole" ( "Femara"), "Anastrozole" ( 'Arimidex') da kuma "Exemestane" ( "AROMASIN") .

Ginshikai na mataki na anti-estrogen kwayoyi a cikin wannan kungiyar - da tarewa na enzyme (aromatase) a adipose nama, wanda shi ne alhakin adadi kaɗan na estrogen a post-menopausal mata. Ba su shafi cikin ovaries, don haka ne kawai tasiri ga waɗanda mata wanda ovaries ba aiki, ko dai saboda menopause ko saboda da tasiri na luteinizing hormone analog. Wadannan kwayoyi da ake dauka a kullum, a kwaya siffan. Sun yi aiki daidai da kyau a lura da oncological matakai a cikin ƙirjinka da prostate.

Wani lokaci nono magani na bukatar likita ovarian. Wannan za a iya yi tare da kwayoyi analogues na luteinizing hormone-sakewa hormone (LHRH), misali, "Goserelin" ( "Zoladex") ko "leuprolide" ( "Lyupron"). Wadannan kwayoyi toshe siginar da aika zuwa ga jiki da ovaries, don samar da estrogen su. Su za a iya amfani da shi kadai ko kuma tare da "tamoxifen", aromatase hanawa, "Fulvestrant" ga hormonal far a premenopausal mata.