Benzathine benzylpenicillin: description, Properties da aikace-aikace, analogs

Benzathine Benzylpenicillin ne da kwayoyin da kuma nasa ne da penicillin kungiyar. Amfani da su bi duk irin cututtuka da lalacewa ta hanyar kwayoyin cuta mai saukin kamuwa zuwa ta mataki. A wannan labarin, za mu tashi a cikin daki-daki cikin umarnin don amfani, alamomi da contraindications da miyagun ƙwayoyi, kazalika da jerin 'yan takwarorina.

Benzathine benzylpenicillin: bayanin da miyagun ƙwayoyi

Wannan magani ne daya daga cikin na farko rukuni na penicillin maganin rigakafi. Duk da sosai tsawon lokaci aikace-aikace, shi ya ba rasa ta munasaba saboda da fadi da kewayon ayyuka da kuma ikon kashe wani iri-iri na pathogenic kwayoyin. Da miyagun ƙwayoyi, misali, iya jimre da Anthrax, meningococci, syphilis kuma a jam'i na streptococci da staphylococci. An allura kamar yadda a cikin narkewa kamar fili ba a tunawa benzathine benzylpenicillin.

Girke-girke a Latin ne sau da yawa wajabta ta likitoci, sa'an nan da haƙuri da wuya a gane abin da ya ke ba. Don kauce wa wannan rikice, ka kawai bukatar sani da sunan da miyagun ƙwayoyi a cikin wannan harshe - Benzathine benzylpenicillinum.

Yawanci, da miyagun ƙwayoyi ne gudanar intravenously ko intramuscularly. Amma yana yiwuwa da kuma miyagun ƙwayoyi bayarwa a cikin jiki ta hanyar da kashin baya canal, subcutaneously ko ta hanyar shafa yankin.

Benzylpenicillin - kwayoyin hada daga wannan aiki abu. Amma shi shiga da miyagun ƙwayoyi a cikin nau'i na salts. Saboda haka abu za a iya adana na dogon lokaci ba tare da keta saukar. Kuma bayan gabatarwar penicillin G aka saki daga jiki na salts da kuma fara ta antibacterial mataki.

Dangane da oda a cikin abin da gishiri ne mai aiki abu, da dama iri magani. Duk da wannan, duk suka yi wajen wannan sakamako, kuma daban-daban halaye na gwamnati da kuma tsawon lokaci na sakamako.

shaidar

Benzathine benzylpenicillin an wajabta, a cikin wadannan cututtuka:

• Cututtuka na numfashi gabobin (pleurisy, ciwon huhu, mashako, empyema , da sauransu.).
• Cututtuka na genitourinary tsarin (syphilis, kabba da ciwon sanyi, urethritis, cystitis, adnexitis, salpingitis).
• Cututtuka na sama na numfashi fili (mulufi zazzabi, tonsillitis, sinusitis, otitis kafofin watsa labarai, sinusitis, laryngitis, da dai sauransu).
• Surkin jini cututtuka na gani gabobin, ƙashi da fata, mucous membranes (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, cellulitis, rauni kamuwa da cuta, da sauransu.).
• Brain ƙurji.
• Surkin jini meningitis.
• Septicemia, sepsis.
• Amosanin gabbai.
• Peritonitis.
• Cututtuka lalacewa ta hanyar spirochetes (yaws, Anthrax, da dai sauransu).
• Fever sa da bera cizo.
• Cututtuka da lalacewa ta hanyar Listeria, Clostridium, Pasteurella.

Bugu da ƙari kuma, da miyagun ƙwayoyi ne gudanar a prophylactically postoperative rikitarwa da kuma rikitarwa da streptococcal kamuwa da cuta (endocarditis, rheumatic zazzabi, glomerulonephritis da sauransu.).

Pharmacokinetics

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) nan da nan bayan gwamnati fara rarrabu, sakewa da aiki abu. A daidai wannan lokaci da miyagun ƙwayoyi ya zauna a cikin jini na gaba 3 makonni bayan da allura. The ruwa abu da ke shiga da yawa fiye da a cikin nama. Ya kamata a haifa tuna cewa benzyl penicillin ne iya shawo kan placental shãmaki, kuma ya bayyana a cikin madara na shayarwa. Excreted ta hanyar da kodan a cikin canzawa form. A lokacin farko 8 kwanaki saki game da 33% na gudanar kashi.

Pregnancy da nono-ciyar

Kamar yadda muka gani a sama, da miyagun ƙwayoyi ne iya shiga cikin mahaifa da kuma shiga cikin nono. Saboda haka, nono ya kamata a daina amfani da lokacin da gudanarwa da miyagun ƙwayoyi.

A lokacin daukar ciki, da nada da miyagun ƙwayoyi ne zai yiwu ne kawai idan fa'ida ga mata shi ne mafi girma daga kasada ga yaro. A yanke shawara dole ne a yi da likita, mai gargaɗi gaba uwa game da duk yiwu sakamakon.

contraindications

Benzathine benzylpenicillin (girke-girke na iya rubũta likita) yana da yawan contraindications. Ya kamata ba za a wajabta shi a mutane da wadannan cututtuka:

• Rashin ha} uri ga penicillin ko cephalosporin, rashin lafiyan dauki ga su.
• A babban matakin potassium a cikin jini (hyperkalaemia).
• Arrhythmia.
• Hay zazzabi.
• Bronchial asma.
• Koda insufficiency.
• Pseudomembranous colitis.

Kariya medicament gudanar don yara har zuwa watanni shida da kuma prematurely.

illa

Benzathine benzylpenicillin iya sa wasu ke so effects, lissafa su a kasa.

Daban-daban rashin lafiyan halayen:

• zazzabi.
• amya.
• kurji a kan mucous membranes da kuma fata.
• hadin gwiwa zafi.
• eosinophilia.
• erythema multiforme.
• Angioedema.
• exfoliative dermatitis.
• anaphylactic buga.

M halayen na zuciya da jijiyoyin jini tsarin:

• thrombocytopenia.
• anemia.
• coagulation cuta.
• leukopenia.

Bugu da kari:

• stomatitis.
• ciwon kai.
• glossitis.
• zafi a yankin na gwamnati.
• abscesses.
• infiltrates.
• Jade gefe.
• fistulas.

Tare da shafe tsawon amfani da cutarwa fungi da micro-kwayoyin zai iya ci gaba da juriya, sa'an nan da miyagun ƙwayoyi zai rasa ingancinta.

Benzathine benzylpenicillin: umarnin don amfani da

Marasa lafiya girmi shekaru 12, da miyagun ƙwayoyi a matsayin m gwargwado da kuma lura da cututtuka da aka gudanar sau ɗaya a mako a wata sashi na 300 zuwa 600 da dubu. Units ko sau biyu a watan a miliyan 1.2 raka'a.

Kamar yadda m matakan for rheumatism prick magani domin 6 makonni, sau ɗaya a mako don 600 dubu raka'a. A lokaci guda rubũta asfirin ko wasu NSAIDs.

Marasa lafiya matasa, fiye da shekaru 12, da miyagun ƙwayoyi ne gudanar sau ɗaya a mako a cikin kudi na 5-10 dubu. Raka'a da 1 kg.

Tsakanin injections kamata faru a kalla 8 kwanaki. A talakawan sashi na 2.3 miliyan raka'a.

Kafin amfani, da miyagun ƙwayoyi da aka narkar a Saline, ruwa ga allura na wucin gadi ko novocaine (2.5% ko 5%).

Gabatar da miyagun ƙwayoyi iya zama a cikin wadannan hanyoyi:

• intramuscular.
• igiyar jini.
• subcutaneous.
• Lumbar (via da kashin baya canal).
• pleural (ta hanyar da na huhu pleura).
• subconjunctival (via da ocular kyallen takarda).
• drip ta cikin kunne.
• drip ta hanci.
• kai tsaye zuwa abin ya shafa Gabar nama.

Hade da sauran kwayoyi

Benzathine benzylpenicillin (umurci kai tsaye kamar yadda aka nuna) zai iya hulɗa tare da wasu kwayoyi. Ta haka ne ya benzylpenicillin iya samun wadannan matakai: a synergistic, antagonistic da bacteriostatic.

Bugu da kari, da miyagun ƙwayoyi qara tasiri na kwayoyi, na zuwa kai tsaye ba anticoagulants. Da kuma rage tasiri na ethinyl estradiol kuma daban-daban na baka hana.

Yi amfani da tare da NSAIDs, allopurinol, diuretics sakamakon a rage yawan tubular mugunya kuma Ya ƙãra yawa na aiki sashi. Bugu da kari, allopurinol ƙwarai qara hadarin rashin lafiyan halayen.

rigakafi

Dole kafin na farko allura wajibi ne don aspirate. Idan da miyagun ƙwayoyi bazata samun shiga cikin jini, zai iya haddasa ischemia ko embolism. Bugu da kari, akwai iya zama wani ji na tashin hankali, ciki, mai shudewa Heart hangen nesa.

A lokuta inda kana bukatar ka yi biyu injections a lokaci, da miyagun ƙwayoyi ne gudanar a daban-daban da makamai ko gindi.

Lokacin da na farko manifestations na rashin lafiyan far dole ne a katse nan da nan. Kamar yadda yanayi likita iya rubũta alerji magunguna.

Sau da yawa tare da benzylpenicillin sanya "Levorinum" ko "Nystatin", kamar yadda akwai hadarin fungal cututtuka. Saboda haka na tsawon lokaci far da miyagun ƙwayoyi iya faruwa hanawa na hanji microflora wanda ya haifar da bitamin B. A wannan batun, za a iya gudanar da su intramuscular gwamnati na wadannan bitamin.

tsõratar

Benzathine benzylpenicillin sanya tare da taka tsantsan a marasa lafiya da suke gani da dama koda aiki, akwai wani predisposition zuwa rashin lafiyan bayyananen, tare da babban ji na ƙwarai da aiki sashi. A karshe yanke shawara ko da yaushe ya ginu ne tare da likita, wanda ya san tarihin haƙuri.

Ba da shawarar miyagun ƙwayoyi domin lura da neurosyphilis, tun da wannan cuta ba za a iya cimma da ake so taro na aiki abu a cikin haƙuri na jini.

analogs

Akwai sauran kwayoyi da cewa da irin wannan tasiri kamar yadda benzathine benzylpenicillin. Analogs, ba shakka, kuma ya kasance a cikin penicillin kungiyar. Mun jera mafi shahara da tasiri:

• "Gramoks-D" - aka samar a cikin wani nau'i na foda yi nufi ga waddan da baka gwamnati.
• "Amosin" - aka samar a capsules, Allunan, kuma foda na baka gwamnati.
• "Smallpox" - An sanya a cikin nau'i na syrup.
• "Hikontsil" - samuwa a cikin nau'i na foda da capsules na baka gwamnati.
• Azlocillin sodium gishiri - powdered abu daga wanda yin bayani ga igiyar jini allura.
• "Ampicillin" - yana samuwa a cikin alluna, capsules, granules, da latest yin slurry, kuma aka dauka baki.
• "Ekobol" - samar da Allunan.
• "Ospamoks" - An sanya a cikin nau'i na Allunan, capsules da foda na baka gwamnati.
• "Phenoxymethylpenicillin" - yana samuwa a cikin alluna, dragees, granules da powders.
• "Star-Pen" - An sanya a cikin nau'i na granules, wanda aka diluted da kuma dauka baki.
• "Oxacillin" - An sanya a cikin nau'i na Allunan, capsules, wani foda, daga abin da, wani bayani ga allura.
• "Standatsillin" - yana samuwa a cikin capsules.
• Carbenicillin disodium gishiri - aka samar a foda siffan ga yi na allura bayani.

Saboda haka, duk da mun gwada dogon lokacin da amfani da miyagun ƙwayoyi a magani, har yanzu ya kasance daya daga cikin mafi tasiri jamiái da dama cututtuka.