Bisphosphonates - abin da yake da shi? Bisphosphonates for osteoporosis

Musculoskeletal tsarin aikin daya daga cikin manyan ayyuka a cikin jikin mutum. Wannan shi ne wani goyon baya ga duk jikinsu. Kashi kiwon lafiya taka muhimmiyar rawa. Lokacin da akwai matsaloli a cikin gidajen abinci, kashin baya, m samu karaya faruwa, mutumin da ta ingancin rayuwa da aka rage muhimmanci. Wata irin wannan cuta wadda aka sau da yawa tare da irin bayyanar cututtuka ne osteoporosis.

Idan a lokacin da ganin likita, shi ne zai yiwu to muhimmanci inganta haƙuri da yanayin. A halin yanzu, bisphosphonates amfani da su bi osteoporosis. Wadannan kwayoyi na iya bayar da bege na magani. Bari mu ga abin da irin kwayoyi.

Menene bisphosphonates

Its sunan, wannan kungiyar da kwayoyi ya samu saboda abun ciki a cikin tsarin biyu phosphonates. Ginshikai na mataki ya tasiri saboda babbar kamance da pirofosfonatami da cewa suna da manyan tasiri a kan tsari na alli abun ciki a cikin kasusuwa.

Tare da irin wannan tsarin, bisphosphonates hana enzymes cewa za a iya zubar da pirofosfonaty. Suka ze su ɗaure alli ions kuma zana mayar da su a cikin kashi.

A tabbatacce gefen liyafar da wadannan kwayoyi ne cewa kwayoyi dake dauke da bisphosphonates, da kawai a zabe sakamako a kan kwarangwal tsarin, inda jari na alli.

Saboda wannan mataki da magani daga osteoporosis yana yiwuwa ya hana asarar alli da phosphorus, wanda yana da kyau sakamako a kan magani.

irin bisphosphonates

Mutane da yawa har yanzu ba su sani ba game da bisphosphonates. Mene ne wannan? An yanzu ɓullo da tsara ta uku na wannan kungiyar da kwayoyi. Doctors ci gaba da yin amfani da kwayoyi, da kuma na farko da biyu da al'ummomi. Yanzu yawa kwayoyi inherently dauke da bisphosphonates, dukkan su za a iya raba biyu manyan kungiyoyin:

1. Simple ba dauke da nitrogen.
2. A rukuni na bisphosphonates, wanda sun hada da nitrogen - aminobisphosphonates.
   

Bambanci tsakanin kungiyoyin biyu ya ta'allaka ne da cewa suna da daban-daban effects a kan osteoclasts.

Nitrogen-dauke da bisphosphonates

Mene ne wannan? Wadannan kudi a cikin abun da ke ciki ya kunshi wadannan sinadaran:

1. Ibandronatovaya acid nasa ne tsara ta uku, hada kwanan nan an yi amfani da sosai nasarar don rigakafin osteoporosis a mata, musamman menopausal.
2. Zolendronovaya acid selectively abubuwa a kan kashi nama, yana mai pronounced anti-ƙari sakamako. Bisa ga wannan abu samar kwayoyi kamar "Zometa", "Zolendronat".
3. Alendronate sodium correctors da dangantaka da wadanda ba hormonal metabolism a kashi nama, na inganta dace samuwar kashi tsarin.
4. Ibandronate sodium a kan wanda samar "Bonviva", "Boniva", "Bondronat" damuarn osteoclast aiki, amma ba ya shafar da lambar. Wadannan bisphosphonates don lura da osteoporosis ne tasiri, musamman a matsayin prophylactic wakili a menopausal mata.
   

Kasance da sanin cewa, ya kamata ka ba kai-medicate, magani dole ne a wajabta ta likita.

sauki bisphosphonates

Ba dauke da nitrogen bisphosphonate kwayoyi don osteoporosis ma rayayye amfani. Wadannan sun hada da:

1. "Etidronate" a cikin nau'i na alluna da kuma injections. shi ne sau da yawa wajabta ba kawai osteoporosis, amma kuma ga Paget ta cuta, hypercalcemia, wanda ya auku a kan bango na ciwon daji.
2. "Clodronate" da aka bayar a cikin nau'i na capsules, Allunan, kuma mafita. Tasiri osteoporosis da osteolysis.
3. "Tiludronate" yawanci wajabta kawai ga manya suka sha wahala daga Paget ta cutar. Yara, shi ne contraindicated.
   

An yi imani da cewa wadannan kungiyoyin biyu na kwayoyi da daban-daban effects a kan namiji da mace jiki, don haka kyau Ladies ne mafi alhẽri dace nitrogen-dauke da magunguna. A cikin wani hali, da zabi ne a yi kawai your likita.

Inganci a cututtuka daban-daban

Akwai dukan jerin cututtuka ga wanda bisphosphonate far iya samun kyau sakamako.

1. Osteoporosis.
2. Myeloma.
3. Deforming osteodystrophy.
4. Primary hyperparathyroidism.
5. Take hakkin da aiwatar da kashi samuwar.
6. Lokacin da kashi metastases.

Kowace daga cikin wadannan yanayi ne kawai likita ta zayyana wani magani, ta sashi da tsawon amfani. Tsunduma a kai-magani, zai iya kawai cutar da jiki.

inji na mataki

Tun bisphosphonates for osteoporosis kwayoyi ne mafi yadu amfani, ya zama dole ga elucidate ginshikai na su mataki.

Duk da Kwayoyin a jikin mu ana sabunta lokaci zuwa lokaci, wannan za a iya ce game da kashi. Yana yana kiyaye ta a ma'auni na osteoblasts, wanda ke da alhakin kira na sabon nama, da kuma osteoclasts ne alhakin ta hallaka. Saboda haka, ko ta yaya BF ta hanyar mu'ujiza impede aikin osteoclasts, da kuma a wasu lokuta ma fararwa inji na kai-halaka.

An ce, a halin yanzu lokaci, masana kimiyya sun kasa cikakken gane yadda za a gudanar da bisphosphonates block kashi halaka. An sani cewa wadannan kwayoyi iya guda biyu tare da hydroxyapatite a cikin kashi rabo, game da shi, canza lankwasawa kashi.

Zaka kuma iya lura cewa idan amfani da na dogon lokaci, da cewa ga ciwon daji far dangane da wadannan gwada da kwanan nan bisphosphonates amfani da su bi osteoporosis.

Bisphosphonates metastases

Tare da ci gaba da ciwon daji ta zo da wani mataki a lokacin da ciwon daji Kwayoyin karya daga primary ƙari kuma ta baza a ko'ina cikin jiki. A cikin sabon wuri da suke a haɗe da kuma fara girma, forming metastases.

A kashi nama ne kullum ana updated, don haka shi qara da alama na kamuwa da cuta da hematogenous. Lokacin da ciwon daji Kwayoyin samun a cikin bargo, suka rushe al'ada interplay tsakanin osteoclasts da osteoblasts, wadda take kaiwa zuwa mahaukaci cin gaban kashi nama.

Tun da sanin gaban metastasis ne da wuya, saboda a farkon matakai, wannan tsari ya auku kusan ba tare da bayyanar cututtuka, da ciwon daji dole wuce na sosai jarrabawa don gane sakandare foci.

Daga cikin dukan jiyya metastases Bisphosphonates an yadu amfani. Wadannan kwayoyi suna quite sauƙi jure da marasa lafiya, su da wuya da illa.

Su za a iya hade tare radiotherapy da jiyyar cutar sankara. Lokacin amfani da irin wannan kwayoyi da aka gano a rage a cikin abin da ya faru na kashi metastasis a nono, da kuma mahara myeloma.

Lokacin tasowa hypercalcemia wanda shi ne kusan al'ada a oncological cututtuka, magungunan da mafi girma da sakamako a cikin nau'i na injections da infusions. Excellent sakamakon sun nuna irin wannan hanyar a matsayin "Zolendronovaya acid", "Pamidronate". Riga 'yan kwanaki bayan qaddamarwa na lura da gwaje-gwaje nuna maido da jini alli, da kuma sakamako na iya dage don har zuwa kwanaki da dama.

Specific shawarwari domin samun bisphosphonates

Idan ba ka ji game da bisphosphonates, abin da shi ne, gaya likita. Yarda da wadannan kwayoyi kamata a da za'ayi a cewar wasu sharudda:

• Dole ne ka dauki magani bayan tada, akalla sa'a daya kafin a ci abinci.
• Wanke saukar da yalwa na ruwa ya kamata.
• Kada ka yi amfani zapivaniya sauran taya, kamar 'ya'yan itace, shayi, kofi. Sun hana sha na bisphosphonates.
• Bayan da yin amfani da Allunan ba zai iya kwanta, daukan game da rabin sa'a a cikin wani mike matsayi domin su qaddamar da esophagus ya kadan.
• An ba da shawarar hada da liyafar BF da alli supplementation, magnesium, iron, kuma aluminum.

Idan ka bi dukkan wadannan shawarwari, da bisphosphonate ba zai kawo maras so illa.

Bisphosphonates for osteoporosis: ribobi da fursunoni

A lura da amfani bisphosphonates for osteoporosis. A kwayoyi suna amfani daidai da kyau ga mata da maza. Babban abũbuwan amfãni daga wadannan kwayoyi iya sun hada da:

• Yana ba ya dauke da hormones.
• Kada taimaka ga ci gaban zuciya da jijiyoyin jini cututtuka.
• M marurai amfani BF ba ci gaba.

Amma a cikin wani maganin shafawa ne ko da yaushe zai yiwu a sami wani gardama a cikin maganin shafawa. Bisphosphonates, duk da inganci da magani daga osteoporosis, shi ne har yanzu nisa daga m. Wuce kima entrainment liyafar iya ba da wadannan illa:

• Adversely shafi hanta da kuma kodan.
• Idan gudanar intravenously, shi ne kusantar wajen samar da hypocalcaemia.
• Yana iya zama esophagus ko ciki miki.
• Akwai rashes a jiki.
• A wasu akwai wani janar wani rauni, malaise, da kuma tashin zuciya.
• Pain a cikin tsokoki.
• Vision matsaloli.
• Zawo ko gudawa.
  

Ba za mu iya ce cewa duk wadannan ba a ke so illa dole ne bayyana kanta a kowane haƙuri, amma kana bukatar ka sani game da su. Idan kana wajabta bisphosphonates, abin da shi ne, bayyana ga likita, ya za a zabi guda miyagun ƙwayoyi sashi da tsawon magani.

Irin wannan kwayoyi ne tasiri da magani daga osteoporosis da kuma sauran cututtuka. Kafin ka sanya wani magani, likita ake bukata don gudanar da wani binciken don gano Jihar metabolism a cikin kashi da alli homeostasis, don haka ba tunanin kanka to rubũta kwayoyi a cikin wannan kungiya.

, Kana bukatar ka kai da lafiya salon, bi duk shawarwarin da likitoci, ci dama don kauce wa samun koma ga magani. Kawai a cikin wannan hali, ka kwarangwal tsarin zai zama lafiya.