"Merten": analogues, umarnin don amfani, real

Medicament "Merten" - Example ingancin Generic "CRESTOR" dauke da matsayin aiki sashi rosuvastatin. A nasa ne da statin aji na Generation IV kuma gabatar a cikin asibiti yi a 2003. Its aikace-aikace ne m, a cikin hali na hypercholesterolemia kuma kamar yadda wani karin hanyar hana m jijiyoyin bugun gini thrombosis. A wannan rawa, da miyagun ƙwayoyi "Merten", analogues na wanda ba yawa, amma sanannun, cikakken zaune har zuwa ta nufi.

saki Form

Tableted sashi form "Merten" miyagun ƙwayoyi analogs rasa da rajista cinikayya sunayen tsakanin film-mai rufi. Ciki shi ya ƙunshi rosuvastatin alli da excipients: lactose monohydrate, microcrystalline cellulose, hydroxide da magnesium stearate, crospovidone type "A". Aras film shafi qunshi polyvinyl barasa, macrogol 3350, talc da titanium dioxide. Shi ne mafi sauki fiye da na 'Crestor "shiri, ko da yake azurta sauka a hankali saki rosuvastatin.

Akwai sashi halitta 4: Allunan na 5, 10, 20 da kuma 40 MG. Ya ƙãga halittarku Allunan cushe a blisters a kwali kwalaye suya. Daya bororo SIM ya ƙunshi 30 Allunan, abin da ya ishe ga watan magani. A wasu asibiti yanayi intelligently amfani da daya daga ce allurai, wanda zai iya daga baya za a modified. Sayen magani miyagun ƙwayoyi da ya kamata a kiyaye a cikin wani dumi, bushe, duhu wuri, daga isar yara.

A tanadi na umarnin don amfani

A haɗe zuwa da miyagun ƙwayoyi "Merten 10 MG" wa'azi ƙunshi bayani game da asibiti alamomi, contraindications, dosing gwamnatocin da illa. Yana bayyana cikakkiyar yiwu miyagun ƙwayoyi interactions magani, muhimmanci asibiti shawarwari. Drug sayen magani, da kuma shi ne ba samuwa ba tare da takardar sayen magani ga wani haƙuri. Saboda haka, da suka fara zuwa kai "Merten" analogs ko Generic "CRESTOR" kuma duk statin kwayoyi, ƙayyade jini sia sulusi da murabba'i kuma ka yi shãwara da likita ko likitan zuciyar.

alamomi

Kafin amfani da samfurin yana da muhimmanci ayyana alamomi da kuma gano wani irin hypercholesterolemia. jini sia profile bada cikakken bayanai game da take hakkin sia metabolism da kuma ta fim. Target alamomi ga yin amfani da su ne kamar haka:

• heterozygous iyalinmu (hereditary) hypercholesterolemia.
• farko (kwayoyin) polygenic hypercholesterolemia irin IIa, classified by Fredrickson.
• hada dyslipidemia IIb classified ta Fredrickson.
• Homozygous iyalinmu (hereditary) hypercholesterolemia.
• Atherosclerosis da kuma yanayin da tsananta zuciya da jijiyoyin jini hadarin (ƙãra yawa na jimlar cholesterol, kuma (ko) da low yawa sulusi da murabba'i).
• atherosclerosis, cerebrovascular da kuma cututtukan zuciya da na matsayin wani ɓangare na daidaita hade magani (duba bayani.).
• lura da hypertriglyceridaemia (IV irin bisa ga Fredrickson dyslipidemia) a hade tare da abinci da kuma motsa jiki danniya.

Bayani daga cikin alamomi

The shaida tushe dangane da gaskiyar cewa karuwa a low-yawa kasarun adadi (LDL) lipoproteins dake dauke da wani yawa na cholesterol, shi ne babban isa. An sani cewa mai tsanani da kuma kudi na zuciya da jijiyoyin jini da kuma cerebrovascular cututtuka dogara a kan sa hannu jini taro na cholesterol, kuma LDL. Wannan halitta abubuwan da ake bukata don ci gaban atherosclerosis, da samuwar plaque a cikin jijiyoyi na roba nau'in. A hankali a hankali girma na plaque Narrows su lumen, rage bandwidth tasoshin sa kullum ischemia ciyar da jiki.

A cewar wannan inji shi ne ci gaban da cerebrovascular cuta, kullum reshe ischemia kuma cardiac ischemic cututtuka. Na roba arteries aka gabatar a wasu yankunan na jiki, wanda halitta abubuwan da ake bukata don ci gaban reshe atherosclerosis obliterans. Tsokar zuciya infarction da kwakwalwa tasowa saboda da iri na jijiya endothelium da jirgin ruwa plaque da kuma m thrombus samuwar. Last kara Narrows da lumen na arteries ciyar da jiki, saboda abin da bangaren kwakwalwa ko myocardium mutu.

A tasiri na m amfani da statins farko uku ƙarnõni, kazalika da mafi samfurin, "Merten" umurci manual, reviews, da kuma shawarwari don clinicians cikakken wajaba a kansa. Adult ba tare data kasance CHD bayyanar cututtuka, amma tare da hadarin ta ci gaba, shi ya bada shawarar "Merten". Shi ne m yana da shekaru 50 da shekaru for maza kuma shekaru 60 na mata.

contraindications

A haɗe zuwa da miyagun ƙwayoyi "Merten" wa'azi, real likitoci, da kuma sakamakon da yawa na asibiti karatu sun tabbatar da kasancewar gagarumin cikakkar da kuma zumunta contraindications lokaci. A yanayin da cikakkar miyagun ƙwayoyi ba za a iya amfani da shi, alhãli kuwa da wucin gadi Contra yarda da aikace-aikace. Cikakkar contraindications ne:

• The aiki lokaci na cutar hanta, cytolysis ciwo ko fiye da uku-Musulunci karuwa a transaminases.
• kullum insufficiency na hanta aiki tare 9 maki a kan sikelin Child-Pugh.
• kullum na koda gazawar da nuna alama ayyuka da creatinine yarda kasa da 30 ml / min.
• asibiti tabbatar myopathy (tsoka zafi ciwo ko rhabdomyolysis, haƙuri propensity zuwa wani miotoksicheskim rikitarwa).
• da bukatar "Cyclosporin" shiri domin zalunta cututtuka na profile;
• rashin iyawa don amfani hana, ciki, lactation, kuruciya da kuma samartaka (18 years).
• Karuwan ji na ƙwarai to mutum aka gyara, da kuma (ko) wani rashin lafiyan dauki ga wani abu rosuvastatin sashi form.

Bugu da kari, waɗannan wasu musamman contraindications na musamman ga dosing 40 MG "Merten" shirye-shiryen. Umarnin don amfani da analogues na kasa da kasa na asibiti jagororin bayyana da wadannan cikakkar contraindications:

• duk aka ambata a baya contraindications, fãce kullum na koda gazawar (40 MG / rana za a iya gudanar da kawai da creatinine yarda fi 60 ml / min).
• hypothyroidism.
• hereditary cututtuka na tsoka nama.
• a hade amfani da fibrates.
• Mongoloid tseren (haramta sanya mafi girma fiye da 20 MG da rana).
• Syndrome barasa dogara.
• na farko liyafar na rosuvastatin.

The asali miyagun ƙwayoyi "Crestor da wani rosuvastatin (a cikin wannan harka" Merten ") analogues (ma'ana) da kuma ta Generic iya ba za a gudanar a wata kashi na 40 MG kafin har hypolipidemic far aka ba da za'ayi a wani m kashi. Kawai a lokacin da 20 MG kullum kashi da aka ba su isa ba normalize sia profile, wanda aka tabbatar da yin lipidogram bayan 4 makonni daga lokacin da far ake bukata nufi 40 MG da rana. Haka kuma, wannan shi ne ya halatta in babu takamaiman contraindications zuwa 40 MG.

sashi gyara

A lokacin da zabi da dosing regimen Guide a haɗe zuwa da miyagun ƙwayoyi "Merten" wa'azi a kan aikace-aikace, da lissafi mai tsauri duniya takwarorinsu, ɓullo a kan tushen da na asibiti da jagororin AHA da QShortcut, kuma mutum halaye na haƙuri. 5 MG na da miyagun ƙwayoyi ne nuna domin lura da hypercholesterolemia IIa da IIb, IV irin bisa ga Fredrickson dyslipidemia. A rigakafin ischemic cututtuka hade da cin gaban atherosclerosis, da shawarar kashi ne ma 5 MG.

A kullum kashi na 10 MG "Merten" bukata da magani daga ischemic cututtuka da endothelium na atherosclerotic plaque karfafawa da kuma hana ta bazuwa. Wannan gaskiya ne ga karanta wani sashi na 20 MG, ko da yake wannan adadin miyagun ƙwayoyi ingantaccen amfani a high dabi'u na low yawa sulusi da murabba'i PL da cholesterol, da kuma a low yawa daga high yawa lipoprotein kasarun adadi. A sashi na 40 MG iya gudanar a wata low yadda ya dace da 20 MG sia profile bayan kimantawa. A cewar yanzu shawarwari AHA da QShortcut, da kullum kashi "Merten" za a iya ƙara zuwa 80 MG.

Features liyafar

Babban tushen bayanai game da liyafar "Merten" miyagun ƙwayoyi - umarnin don amfani. Analogs da Generic "CRESTOR" an yi amfani da bisa ga shawarwari. Bisa ga fasali na pharmacokinetics na alluna rosuvastatin (a cikin wannan harka, "Merten") an yarda a kowane lokaci na rana. Su ya kamata a yi lõma da dukan da sha yalwa na ruwa 50-150 MG. Amma, kamar yadda da shawarar da QShortcut da AHA daga 2014, ya dauki wani statins ya zama kafin lokacin kwanta barci, kyalewa da a haɗe umarnin don amfani.

illa

M illa "Merten", da mita daga wanda yake 1-10%, suna dizziness, myalgia, tashin zuciya, maƙarƙashiya, zuba ciki zafi, gajiya, ciwon kai. Wanda ba safai ba ne illa na mita 0.01-1%: rashin barci, amya, itchy fata, yanayi canje-canje a cikin tawayar shugabanci. Rare effects (0.0001-0.01%): myositis, myopathy, rhabdomyolysis, sashin jiki-kara hanta transaminases, panreatit, angioedema.

Musamman rare effects: jaundice saboda guba hepatitis, hadin gwiwa zafi, hematuria, memory asarar, m exudative erythema. Da suka faru kasa da 1 hali ta 10 000 marasa lafiya. Shi ne kuma zai yiwu kuma wani ɓangare na sakamako - karuwa jini glucose da kuma ci gaban da na biyu da irin ciwon sukari. Side effects ne kashi-dogara, kuma su mita ƙaruwa tare da kara sashi. Tare da kara allurai kullum sau biyu yadda ya dace karuwa da kawai 6-10%.

Features na hadaddun hulda "Merten"

Wasu magunguna suna halin da karuwa ko karu a yawan guba yadda ya dace yayin da yin amfani da shiri "Merten". Analogs, real kwararru da suke tabbatar da wannan Trend ma halin da muhimmanci miyagun ƙwayoyi interactions. Haramta concomitant amfani "Merten" da "Cyclosporin" saboda fiye da 7-Musulunci karuwa a cikin jini maida hankali a statin.

All rosuvastatin kwayoyi bunkasa sakamako na coumarin anticoagulants wani abin da bukatar INR saka idanu da kuma sake gyara. A lura da HIV ba da shawarar yin amfani da lokaci guda "Merten" da kuma protease hanawa ( "LPV" da sauransu). Idan dole, magani nonabsorbable antacids ya kamata a dauka bayan 2 hours daga lokacin da na aikace-aikace na wani statin. Idan hada magani tare da kwayoyi da shafi da cytochrome gyara kashi "Merten" ba a bukata.

Analogs "Merten"

A shirye-shiryen "Merten" analogues ne 'yan. Total kantin magani a kasuwannin cikin gida da akwai ba fiye da 10 musamman abun da ke ciki. Na farko kuma mafi ingantaccen ne "Crestor". Wannan shi ne asalin rosuvastatin, wanda aka sake ta AstraZeneca. "Crestor" Akwai ma da dama sauran kasashen waje Generic miyagun ƙwayoyi. Wannan "Rozulip", "Roxer", "Tevaskor", "Rozart", "Rozukard". Kwayoyi kamar "AKORT" da "Rosuvastatin Canon", kusan m, a abun da ke ciki shiri "Merten" - Rasha takwarorinsu. Sun samar da m pharmaceutical kamfanonin.

Review na shirye-shiryen "Merten"

Marasa lafiya shan sia-ragewan kwayoyi, ba zai iya tabbatar da ko ƙi yarda da tasiri na musamman miyagun ƙwayoyi. Duk da haka, bisa sia profile sakamakon, kimani gwani, za ka iya yin hukunci da ingancin da miyagun ƙwayoyi. "Merten" for watanni 3 a wata warkewa kashi daidai a cikin lipid profile na jini magani. A asibiti sakamako iya gani a cikin 4-6 makonni. Saboda haka, saboda da rauni tsitohromovogo hanta metabolism, shi yana da kananan adadin miyagun ƙwayoyi interactions.

Marasa lafiya na "Mertenile" amsa gaskiya ma saboda low faru na m halayen. A amfani da wani sauki harsashi ga Allunan rage hadarin na gida gastrotoksicheskogo sakamako. Kan yadda za a amsa, marasa lafiya, tashin zuciya da kuma dyspepsia faruwa da yawa kasa akai-akai fiye da a cikin hali na farkon statin ( "Simvastatin" da "pravastatin"). Haka kuma, bisa ga shawarwarin da cardiologists, a kan tasiri na "Merten" Insignificance na baya "Crestor". Sauran analogues a cikin abun da ke ciki na da irin wannan warkewa darajar.