"Probenecid": umarnin don amfani, analogs, reviews

Me ne mai magani "Probenecid"? Umarnin don amfani, ma'ana, equivalents da kuma alamomi ga yin amfani da miyagun ƙwayoyi za a jera a kasa.

Form, abun da ke ciki

Mene ne probenecid? Umarnin a kan aikace-aikace na da'awar, wanda shi ne mai aiki abu da aka samu a cikin da yawa kayayyakin. Sayi wannan magunguna iya zama a wani kantin magani a wani araha farashin. Su za a iya samar a cikin nau'i na Allunan, capsules, kuma ko da foda ga dakatar.

A pharmacological mataki da miyagun ƙwayoyi

miyagun ƙwayoyi "Probenecid" Yaya ta yi aiki? Umarnin don amfani, reviews da'awar shi arthrifuge wanda yake iya zuwa hana reabsorption na uric acid a cikin koda tubules, da kuma muhimmanci inganta ta tukar tumbi.

Bayar da rahoton kwararru gagarumin karuwa a tukar tumbi da uric acid a ƙarƙashin rinjayar da dũkiyõyinsu a tambaya na iya kara tsari daga tophi ta saki a cikin jini, abin da kyakkyawan haifar da ci gaban da wani m hari na gout.

Har ila yau, da miyagun ƙwayoyi "Probenecid", umarnin don amfani wanda aka bayyana a kasa, sau da yawa take kaiwa zuwa jinkiri tukar tumbi da kodan wasu kwayoyi ta kara da taro a cikin jini. Wannan damar yin amfani da kudi a matsayin ƙarin magani a lokacin da kwayoyin far.

sanadin motsi halaye

wani magani "Probenecid" sucked? Da zarar ciki shi an tunawa daga cikin gastrointestinal fili. A ganiya maida hankali a cikin jini na probenecid aka samu bayan sa'o'i uku, kuma ta dauri sunadarai ne game da 85-96%.

Ina tsakiyan nonon da miyagun ƙwayoyi a karkashin shawara? Bisa ga umarnin, shi ne metabolized a cikin hanta. Wannan Forms da asali atsilglyukuronidny da sauran metabolites.

Probenecid ne fitarwa ta hanyar aiki mugunya da kodan proximal tubules da glomerular tacewa. A cikin fitsari na haƙuri da aka gano game da 75-86% na metabolites, da saura ne excreted canzawa a (dangane da kwarara kudi na fitsari, da kuma acidity).

shaidar

Wanne ya bi cututtuka na miyagun ƙwayoyi "Probenecid"? Umurnai na amfani bayar da hujjar cewa wannan wakili ne tasiri a hyperuricemia bayyana kanta far ga kullum gout kuma hyperuricemia amfani da diuretics.

Ba za mu iya ce cewa kamar yadda wani karin hanyar wannan magani an wajabta, a lura da kwayoyin penicillins da cephalosporins.

contraindications

A wasu lokuta, shi haramta yin amfani da "Probenecid"? Umurnai na amfani yana nufin wannan contraindications da miyagun ƙwayoyi, kamar:

• porphyria.
• m hari na gout.
• a lokacin daukar ciki.
• urolithiasis (ciki har da gaban urate duwatsu).
• Yara a karkashin shekaru biyu na shekaru.
• sabawa a ƙididdiga na gefe jini.
• hypersensitivity zuwa probenecid.
• secondary hyperuricemia wanda aka sa ta yin amfani da tsoka jamiái ko ciwon daji tsari.

Medicament "Probenecid": umarnin don amfani da

Analogues na wannan kayan aiki za a jera a kasa.

A kullum gout miyagun ƙwayoyi ya kamata a dauka a karkashin shawara a kashi na 250 MG sau biyu a rana daya watan. A mako bayan da farkon magani, yana yiwuwa ya kara yawan daidai sau biyu.

A hali na kasa warkewa sakamako daga cikin kashi za a iya ƙara kowane wata a kan 500 MG. Ya kamata a tuna cewa matsakaicin kashi na medicament ne 2 g a rana.

Idan a cikin watanni shida da haƙuri ba shi da wani m harin da gout, kuma urate jini matakan kada ku ƙẽtare halal, sa'an nan da nuna adadin da miyagun ƙwayoyi za a iya hankali rage ga m tasiri (msl, a 500 MG kowane watanni shida).

A sashi na probenecid mutane samun diuretics ko pyrazinamide iya karu.

Lokacin dauke da fitar da magani daga cikin kwayoyin penicillin shirye-shirye da kuma cephalosporin adult marasa lafiya rahoton magani wajabta zuwa 500 MG sau hudu a rana.

A yara shekaru shekaru biyu, na farko kashi na medicament ya zama 25 MG da kg jiki nauyi, bi da kara zuwa 40 MG da kg. A lokaci tazara tsakanin allurai da miyagun ƙwayoyi ne 6 hours.

A lura da kabba da ciwon sanyi nufin "Probenecid" za a yi amfani a cikin wani sashi na 1 g kowace awa daya da rabi zuwa parenteral gwamnati na kwayoyin.

illa

Mene ne halayen da wani mummunan hali zai iya sa magani "Probenecid"? The Dokokin annexed da miyagun ƙwayoyi, da ya nuna da wadannan illa:

• itching, anorexia, nephrotic ciwo, ciwon gumis.
• ciwon kai, zazzabi, dizziness.
• urticaria, tashin zuciya, m urination, amai.
• leukopenia, Stevens - Johnson, hanta necrosis, alopecia.
• anaphylaxis, dermatitis, anemia, da kuma tides.
• hemolytic anemia, worsening da gout, aplastic anemia.

miyagun ƙwayoyi interactions

Bisa ga wa'azi, irin wannan aiki abu, kamar probenecid, zai iya rushe tukar tumbi da kara maida hankali a cikin jini da irin magunguna a matsayin "Captopril", "Acyclovir" conjugates sulfonamides, "Paracetamol" sulfonylureas "naproxen", aminosalicylates, "Methotrexate" "lorazepam", "meclofenamate", "Rifampicin" "Indomethacin", "AZT" da "Ketoprofen".

Har ila yau, lura da cewa dauke da miyagun ƙwayoyi rage taro a cikin fitsari da kuma penicillamine nitrofurantoin cewa rage su warkewa sakamako a cystinuria da kuma urinary fili cututtuka, bi da bi.

A medicament "Probenecid" Yanã da karuwa a tukar tumbi aminogippurovoy acid fenilsulfontaleina, 5-hydroxy-indoleacetic acid, kuma sulfobromftaleina da kuma rage tukar tumbi da metabolites na steroid hormones a fitsari.

Specific bayanai

Abin da ya kamata ka sani kafin yin amfani da miyagun ƙwayoyi da probenecid? Bisa ga umarnin, irin shirye-shirye ba da shawarar don amfani a sakandare hyperuricemia wanda aka sa ta tumoral tsari ko amfani da tsoka jamiái, kamar yadda ya ce abu ba rage kira na uric acid da kuma kawai qara ta koda tukar tumbi tsarin. Tasowa a lokaci guda hyperuricosuria iya kara hadarin nephropathy.

Tare da matsananci hankali rahoton miyagun ƙwayoyi ya kamata a yi amfani da mutane da peptic miki cutar da kullum na koda gazawar. A karshen harka, probenecid iya zama m.

Lokacin amfani da wannan medicament domin lura da kullum gout iya ci gaba da m hari, da kuma ƙara girma na koda calculi.

Mutane da G6PD rashi iya sa haemolytic anemia.

Overdosing probenecid haddasa CNS ruri, da inganta harkokin seizures, da kuma na iya haifar da mutuwa saboda numfashi gazawar.

Wajibi ne a kauce wa lokaci daya liyafar tare da probenecid "ketorolac" da kuma salicylates.

Mutane shan wannan magani, na bukatar low sashi "thiopental" domin gwamnati na maganin sa barci.

A cikin layi daya aikace-aikace na methotrexate da probenecid farko kashi ya kamata a rage domin rage illa.

Duk da yake shan wannan magani zai yiwu ƙarya sakamakon tabbatacce a kan glucose fitsari gwajin.

Analogues, ma'ana

Da miyagun ƙwayoyi za a iya maye gurbinsu "Probenecid"? Analogues na wannan kayan aiki za a iya saya a wani kantin magani. Wadannan sun hada da wadannan: "Phytolysinum", "Tsitrokas", "Uronefron", "Uroholum", "Baytach", "Cystone", "wannan tarihi", "phytol", "Urohol" da sauransu.

Amma ga ma'ana, irin wannan magani yana nufin su a matsayin "Santoor".

Reviews na arthrifuge

Abin baƙin ciki, mabukaci sake dubawa, "Probenecid" shiri, akwai ba sosai. Duk da haka, a lokacin da wani sako "Santoor" yawaita. Marasa lafiya suna da'awar cewa da miyagun ƙwayoyi ne da bayyana a lura da hyperuricemia a marasa lafiya da na kullum gout kuma hyperuricemia lokacin da yin amfani da diuretics. Har ila yau shi ne mai kyau warkewa wakili don m kwayan cystitis, nonspecific urethritis, postoperative urinary fili kamuwa da cuta da sauran urological matsaloli.

Ba shi yiwuwa ba a ma maganar gaskiya cewa rahoto na magani a can ne ma korau bangarorin. Masu amfani da su sun hada da yawa illa da kuma contraindications.