Da miyagun ƙwayoyi "Avastin": haƙuri shedu, umarnin don amfani, illa

Da miyagun ƙwayoyi "Avastin" An dauke da wani antitumor wakili, wanda yana nufin monoclonal antibodies. A lokacin aikace-aikace na da miyagun ƙwayoyi ne a rage ci gaban metastatic cutar da kuma microvascular permeability a m marurai na daban-daban iri, musamman ma wadanda suke game da mace nono, ciwon, da kuma pancreas da prostate.

da miyagun ƙwayoyi

Samuwa miyagun ƙwayoyi "Avastin" a cikin wani nau'i na tattara wadda aka yi nufi ga shirya da mafita ga jiko na iya zama colorless ko dan kadan brownish m.

Ainihin miyagun ƙwayoyi abu ne bevacizumab. A kayan aiki yana samuwa a kunshe na 100 MG, da 4 ml na aiki abu da kuma 400 MG / 16 ml.

pharmacological effects

"Avastin" - da ƙari miyagun ƙwayoyi da cewa damuarn samuwar sabon jini da cewa samar da oxygen da kuma gina jiki ga kyallen takarda neoplasms kuma, da ita bada damar canja wurin wani m ciwon daji a cikin kullum mataki. "Avastin" (martani da marasa lafiya da kuma likitoci - hujja) ya aikata overwhelmingly a metastasis na daban-daban m siffofin maruran.

Domin da wannan kayan aiki halin da kadan adadin yaduwar a cikin jiki, a Bugu da kari, yana da dogon isa cire daga jiki, wanda damar domin tabbatar da ake bukata adadin da babban bangaren na miyagun ƙwayoyi da alura da shi tsananin bisa ga umarnin - sau daya a cikin 14-20 kwanaki. Samu magani samfurin ne ba a cikin hanta ko koda, da kuma a duk Kwayoyin na jiki for 18 days for maza kuma na mata - 20.

Amma da yake mai kyau "Avastin"? Shedu ce cewa wannan shi ne mai matukar tasiri miyagun ƙwayoyi, idan ka hada shi da jiyyar cutar sankara a daban-daban na cutar kansa. Wannan yana nufin da yawa qara rayuwa lokaci na marasa lafiya a duk kungiyoyin, tare da ci gaban da cutar faruwa.

"Avastin": alamomi ga yin amfani da

Wannan magani ne yadu amfani a ciwon daji far. Doctors rubũta shi:

1. A metastatic colorectal ciwon daji. Da miyagun ƙwayoyi ne shawarar don amfani a tare da jiyyar cutar sankara dangane da 'fluoropyrimidine'.
2. A metastatic nono. Ana amfani da matsayin farko line na jiyya a tare da tare da "paclitaxel".
3. Lokacin da inoperable, tare da babban yawan metastases ko neplosko-, wadanda ba kananan cell huhu da cutar daji - a matsayin na farko line far a hade tare da jiyyar cutar sankara platinum tushen magani shirye-shirye.
4. A ci-gaba ko metastatic ciwon daji, shafi koda Kwayoyin - a matsayin wakili don primary far a tare da tare da "Interferon Alpha-2A".
5. Lokacin da glioblastoma a tare da radiation far da 'temozolomide' a da marasa lafiya da suke sabon kamu, a monotherapy ko a tare da "irinotecan" a marasa lafiya tare da maimaita glioblastoma ko ciwon daji ci gaban.
6. Marasa lafiya da suke kamu da "m ƙari na kaciyar mata", da kuma a primary peritoneal ciwon daji. A wannan yanayin shi ne shawarar sanya da miyagun ƙwayoyi "Avastin" kamar yadda na farko likita far a tare da tare da "carboplatin" da "paclitaxel".

Bugu da ƙari, wata miyagun ƙwayoyi gudanar da "carboplatin" da "Gemcitabine" ba don ci-gaba cuta ko kula platinum-tushen jamiái ga marasa lafiya da ciwon daji na mace al'aura gabobin ko peritoneum, da cewa ba a bi da da da kayan aiki, ko wani irin wani mai hanawa na VEGF.

Yadda za a shigar da "Avastin"?

"Avastin" (martani da marasa lafiya da likitoci tabbatar da shi) - mai kyau miyagun ƙwayoyi, amma dole ne a yadda ya kamata gudanar, da kuma kawai a karkashin kulawa da likitoci. An tsananin haramta shigar da jet - kawai intravenously, sa'an nan kamar yadda sannu a hankali kamar yadda zai yiwu. A lissafi ne 5 MG da 1 kg na jiki nauyi 1 lokaci a cikin makonni biyu.

The bukata adadin tattara aka diluted a 100 ml 0.9% sodium chloride. A farko kashi bada shawarar a shigar da daya da rabi hours bayan jiyyar cutar sankara, da kara allura "Avastin" da aka yi kafin ko bayan hanya. Idan na farko gwamnati da miyagun ƙwayoyi da haƙuri da babu rikitarwa, da more shi za a iya gudanar a cikin sa'a guda, kuma duk m injections - for rabin awa, amma kawai idan na biyu da aka canjawa wuri da lafiya prick da kyau.

Ko kashi da aka ba da shawarar a rage gaban a ke so effects, idan ya cancanta, dakatar ko yanke da magani.

Idan haƙuri an gano metastatic colorectal ciwon daji, da shawarar farko kashi na 5 MG da kg jiki nauyi sau daya a kowace 14 days ko 7.5 MG / kg, amma bayan kowace kwanaki 21. Idan wani na biyu line far, da sashi ne ya karu da sau 2.

Idan mace kamu da cutar daji na nono, a cikin wannan yanayin, da farko allura bada shawarar cewa halitta na 10 MG / kg da a gudanar da wani allura kowane mako biyu. Ko uku, amma a wannan yanayin shi ne riƙi zuwa 15 MG da kg jiki nauyi.

Idan akwai alamun ci gaban cuta, magani ya kamata a tsaya.

Tare da tartsatsi inoperable, maimaita, ko metastatic neplosko- ko maras kananan cell huhu da cutar daji da magani ne da za'ayi a tare da jiyyar cutar sankara kwayoyi Pt (ba fiye da 6 hawan keke), kuma bayan da miyagun ƙwayoyi amfani da monotherapy.

kana bukatar ka daina shiga "Avastin" Lokacin da ka ga alamun ciwon daji ci gaban. Umurnai na amfani jihohin idan babu ci gaban, da lissafi ne 7.5 MG / kg kowane kwanaki 14 ko da sashi ne ya karu da rabin da aka gudanar da sau daya a kowace makonni uku a Bugu da kari ga "cisplatin" da "carboplatin".

A koda cell cancers kashi kada fi 10 MG / kg ga kwanaki 15 da zarar. Idan akwai alamun ci gaban da cuta, da jiyya ya kamata a tsaya.

Mazan mutane ba su da bukatar daidaita da kashi.

"Avastin": yawan abin sama

Drug yawan abin sama faruwa mafi akai-akai, a cikin taron da cewa wani haƙuri da aka kaddamarda high kashi - 20 MG da kg haƙuri jiki nauyi kowane kwanaki 14.

A wannan yanayin, na iya faruwa migraine hare-hare a wani fairly hadaddun tsari, a Bugu da kari, akwai an kara illa aka bayyana a kasa. Musamman maganin guba ba ya wanzu, kawai symptomatic far da ake amfani.

"Avastin": illa

"Avastin" - wani kyau sosai miyagun ƙwayoyi, a mafi yawan lokuta yana taimaka wa rage da ci gaban na tsanani da rashin lafiya, amma sau da yawa marasa lafiya ne kiyaye a ke so effects. A rare lokuta, za su iya zama quite tsanani:

1. Perforation na ciki da kuma hanjinsu.
2. Ciki zub da jini.
3. Jijiya thromboembolism.
4. Karuwan jini da kuma proteinuria tasowa. Mafi m, wannan shi ne wani sakamako na haƙuri kashi martani.

Bugu da kari, marasa lafiya wanda aka nada miyagun ƙwayoyi "Avastin", illa da kuma sauran cututtuka bayyana:

• zurfin jannayẽnsa thrombosis, wani hadadden tsari na zuciya rashin cin nasara, supraventricular tachycardia, zub da jini;
• leukopenia, neutropenia, low haemoglobin thrombocytopenia.
• rashin jin daɗi a cikin peritoneum, ciki cuta, jini a cikin stool, wani m rash a cikin bakinsa, zub da jini gumis, hanji toshewa.
• zub da jini daga hanci, rashin oxygen, na huhu thromboembolism.
• bushe fata, dermatitis, fata sautin.
• asarar dandano, m nauyi asara, syncope, migraine, bugun jini, drowsiness.
• Heart hangen nesa.
• zafi a cikin wurin da medicament aka gudanar.
• zub da jini daga mahaifa, urinary fili kamuwa da cuta, a ji na gajiya, dehydration.

contraindications

Ko duk dace "Avastin"? Shedu ce cewa wannan shi ne mai kyau miyagun ƙwayoyi, amma duk da haka shi ma yana da contraindications da amfani, da kuma kafin ka fara jiyya, likita dole gaya maka game da su. A miyagun ƙwayoyi ya kamata ba za a wajabta a cikin wadannan lokuta:

• idan akwai wani musamman rashin ha} uri babban aiki sashi.
• Akwai cututtuka da ido da kuma periocular yanki.
• faruwa Intraocular kumburi.
• shekaru 18 da shekaru.
• Pregnancy kuma lactation.

Bugu da kari, idan haƙuri yana da damar bugun jini, sa'an nan prick "Avastin" sa kawai bayan da haƙuri nazarin da zo a ƙarshe cewa da miyagun ƙwayoyi amfani.

tsõratar

Bi da miyagun ƙwayoyi ya kamata kawai likita wanda ke da kwarewa da yin intraocular injections.

Bayan da kayan aiki da aka gabatar, yayin da shi ba da shawarar samun a baya da dabaran a mota da kuma yi aikin hade da sunadaran da duk saboda abin da na iya ci gaba mai shudewa gani disturbances.

"Avastin" (manufacturer da aka nuna a cikin umarnin) dole ne kawai a adana a cikin firiji, yayin da a wani hali da shi dole ba za a daskarewa. Yana wadãtu da takardar sayen magani kawai.

Yadda za a yi mu'amala "Avastin" tare da wasu kwayoyi?

Drug "Avastin" ne m tare da dextrose mafita. Har ila yau, da miyagun ƙwayoyi iya kara hadarin m halayen lokacin dauka a tare da wannan nufin:

• "Sunitinib malate" - na iya faruwa ci gaba microangiopathic hemolytic anemia.
• platinum da taxanes - yiwu rikitarwa na dauke da kwayar cutar pathologies, mai tsanani neutropenia, ƙãra hadarin mutuwa.
• "Panitumumab" da "Cetuximab" - qara mai guba effects da kwayoyi da take kaiwa zuwa mutuwa.

"Avastin" a ophthalmology

Mafi kwanan nan, da bayanai bayyana a latsa cewa miyagun ƙwayoyi "Avastin" amfani da ophthalmologists mu bi da cututtuka na ido da kuma ba da kyau sakamakon. Amma shi ne shi? Abin da wannan ya ce game da manufacturer? Shin wannan kayan aiki da ba ka damar ba kawai dakatar da ci gaban da marurai, amma kuma warkar da cututtuka na hangen nesa?

Eh, a gaskiya akwai bayanai da cewa wasu marasa lafiya sun ji game da amfanin da miyagun ƙwayoyi da ido, da kuma kuskure ya yi harbi "Avastin" a cikin vitreous, amma da sakamakon su m. Da miyagun ƙwayoyi ba su kawo wani waraka, a maimakon haka, ya kai ga cewa mutane suna kawai makafi. "Roche" kamfanin ya akai-akai jaddada cewa, "Avastin" ba za a iya amfani da a ophthalmology, ta nufi shi ne daban-daban.

Da miyagun ƙwayoyi ne aka yi nufi ga rage tsanani da ci gaban da jini da cewa ciyad da ciwon daji, ta haka ne a raguwa a ƙari ci gaban tsanani. Wannan shi ne dalilin da ya sa kafin fara far da kuma sauraron unsubstantiated shawarwari mafi alhẽri tuntubar likita.

"Avastin": takwarorinsu

Amma ga ko akwai wani canza, wanda zai yi a cikin abun da ke ciki shi ne guda na asali abu, shi ba ya sanya su "Avastin". Analogs na inji na mataki ne, kuma su ma ba mai kyau sakamakon a inda hakan ya saukar da ci gaban da jini da kuma ci gaban da cancerous siffofin maruran. Wadannan sun hada da:

• "Arzerru".
• "Campath".
• "Rituximab".
• "MabThera" et al.

Amma shi dole ne a tuna da cewa likita yana zuwa zabi analogue.

"Avastin": martani da marasa lafiya da kuma likitoci

"Avastin" (umurci manual aka tabbatar) ne kawai miyagun ƙwayoyi da cewa ya ƙunshi a cikin abun da ke ciki bevacizumab, yana taimaka wa rage ci gaban da jini ciyar da ƙari, game da shi, inda hakan ya saukar da cutar ci gaban. Mafi yawa daga cikin likitoci ya lura da muhimmancin da cuta a cikin wani musamman haƙuri, suka ce cewa a kamar wata injections kula slowing ƙari girma, babban abu - na da hakkin ya yi da miyagun ƙwayoyi da kuma ba hada shi da kwayoyi da cewa a hade iya haifar da tsanani cutar da mãsu haƙuri.

Rungumar, za mu iya cewa don tabbatar da cewa "Avastin" (m - F. Hoffmann-La Roche) - mai kyau, wanda taimaka tsawanta da rayuwa da marasa lafiya da cancerous siffofin maruran. Amma shi ke kawai dole ne a yi amfani da shi a karkashin tsauraran dubawa na likita, in ba haka ba da sakamakon zai iya zama babu ja da kuma kawo karshen baƙin cikin shine.