Dehydroepiandrosterone sulphate (DHEA-S)

Dehydroepiandrosterone sulphate (DHEA-S) - androgen ne cewa tare da mafarki ba ba alaka. Hada da secreted da adrenal gland shi. Yana da dangantaka da dehydroepiandrosterone sulfate ketosteroids.

DHEA-S aka hada fi mayar da cholesterol ester sulfate. Ainihin adadin androgen catabolized kuma, kamar yadda mai mulkin, kawai goma bisa dari excreted a cikin fitsari.

Dehydroepiandrosterone sulfate ba a hade tare da takamaiman sunadarai a jini jini, saboda haka, su maida hankali a matakin DHEA-S ba ya canzawa. Duk da haka, a steroid binds ga albumin a magani.

Bugu da kari ga DHEA-S a cikin abun da ke ciki na zagawa da jini hada dehydroepiandrosterone. Ɓangare na da samuwar a cikin adrenal bawo auku partially - gonads. Saboda rayuwa yarda da DHEA sosai m, ta maida hankali a kwatanta da DHEA-C da ke ƙasa.

Saboda babban yawa na dehydroepiandrosterone sulfate, high zaman lafiya da kuma tsawo rabin-rai, da kuma gaskiyar cewa tushen da shi, domin mafi yawan bangare, suna adrenal steroid ne mai kyau nuna alama na androgen mugunya.

Baya daga cikin adrenal bawo a maza qananan part (5%) da aka samar a cikin gonads. A mata, da ovaries samar da shi a can. A taro na wannan hormone androgensinteticheskuyu nuna ayyuka na adrenal. Dehydroepiandrosterone sulphate yana da kadan Androgenic aiki. Duk da haka, a lokacin da ta metabolism, wanda ya auku a gefe kyallen takarda, samar dihydrotestosterone da testosterone.

DHEAS yarda kudi low. Wannan nuna alama da ake amfani a cikin ganewar asali hyperandrogenic jihohin da ke faruwa a mata. Wadannan sun hada da alopecia, hirsutism, wani cuta na haihuwa aiki. Kamar wancan hyperandrogenism iya samun ovarian ko adrenal asalin. Saboda haka, endocrinological Nazarin fara da kayyade taro na dehydroepiandrosterone sulfate da testosterone. Ƙara musu Manuniya nuna hyperandrogenism na adrenal asalin. Bugu da kari, cikin kudi amfani da kimantawa da matsayi na androgens a kan bango na jinkiri jima'i ci gaba.

Cikin dukanin ciki, da samar da dehydroepiandrosterone sulfate auku a cikin bawo na adrenal gland da tayin da mahaifiyarsa. Domin kira na estrogens a cikin mahaifa ne a hormone precursor.

A mata masu ciki, dehydroepiandrosterone sulfate taro a jini rage-rage moderately. By lokacin balaga, a yara da matakin ƙaruwa, sa'an nan a hankali rage-rage tare da shekaru.

Dehydroepiandrosterone sulfate ƙãgãwa a:

- nakasar adrenal hyperplasia.

- ciwo (cuta) Cushing .

- marurai na adrenal bawo (darajar ciwon daji ne mafi girma fiye da a wani adenoma).

- polycystic kwai ciwo .

- marurai ektopichesoky kayayyakin.

- verilnom ciwo.

Rage hormone taro lura a:

- sakandare da kuma primary adrenal insufficiency.

- ciki.

- primary hypogonadism (castration, Klinefelter ta ciwo) a cikin maza.

- sakandare hypogonadism (pituitary) a cikin mata.

- baka hana.

- pangipopituarizme.

- osteoporosis.

Dehydroepiandrosterone sulfate, da kudi ga maza 21 zuwa shekaru 39 na 1,0-4,2 g / ml, ga mata daga 19 zuwa shekaru 39 da haihuwa - wani, 8-2,9 g / ml.

A dagagge matakan na testosterone a mata fassara DHEA-S taro za a iya ƙaddara ko jiha na wata cuta dangantaka da ovarian ko adrenal cuta. dehydroepiandrosterone sulfate matakin Manuniya kawai a lokacin da ya karu adrenal pathologies. Wadannan sun hada da, musamman, sun hada da marurai, hyperplasia da kuma sauran cututtuka.