Intranasal - ne mai magani gwamnati? intranasal formulations

Akwai su da yawa ta hanyoyi daban daban, da gabatar da miyagun ƙwayoyi a cikin jikin mutum. A alfijir na farko magani amfani na gida da hanyoyin a cikin nau'i na aikace-aikace, rastirok, compresses, kuma na baka, ciki har da ingestion da dama sashi siffofin ko sublingual sha. mafi hadaddun hanyoyin da aka yi amfani da tare da ci gaban likita da fasaha da kuma isarwa na aiki abu zuwa ga manufa sashin jiki.

Akwai rectal da farji suppositories (suppository), multicomponent Allunan, kuma ya capsules, ciki har da mai rufi Allunan, narkar ko na ciki da ruwan 'ya'yan itace, ko na hanji enzymes. Allura hanyoyin: intra- kuma subcutaneous, intramuscular, igiyar jini da ciki-jijiya, intraosseous. Da miyagun ƙwayoyi ne allura a cikin hadin gwiwa kogo da kuma gabobin.

Duk da mun gwada sauki hanya na gwamnati, endotracheal da intranasal formulations aka yi amfani gwada da kwanan nan. Hakika, da hanci saukad da sun wanzu riga a Hippocrates. Duk da haka, intranasal - wannan shi ne hanya daya da gwamnati domin bayarwa ga sauran gabobin, kuma ba wani magani domin busa a wani sanyi, da kuma irin gwamnatin da aka yi amfani da kawai 'yan shekarun da suka gabata da suka wuce.

Groups intranasal formulations, samar da janar (na tsari) mataki

Da yawa karatu sun bayyana cewa yaki da kowa sanyi - ba kawai dalilin da gabatarwar da miyagun ƙwayoyi a cikin hanci kogo. A yawan kwayoyi da cewa suna da wani tsari mataki, ya zare tunawa daga mucous membrane na hanci sassa da kuma isa ga manufa kai tsaye.

Intranasal gwamnati ne yiwu ga:

• H1-antihistamines (alerji).
• a-adrenoceptor agonists (vasoconstrictors).
• mast cell cakosoban membranes.
• serotoninergic (bayar da daban-daban effects - na vasoconstriction zuwa wani antiallergic).
• hormonal da protivogormonalnyh.
• narcotic analgesics .
• immunomodulators.
• correctors metabolism na guringuntsi da kashi nama.
• psychostimulants da nootropics.

Musamman intranasal gwamnati na kwayoyi

Quite lokaci mai tsawo Pharmaceutical kamfanoni sun yi kokarin warware biyu ayyuka unsolvable tare da girmamawa ga yin amfani da kwayoyi da ciwon da sinadaran tsarin na gina jiki. A nake toshe aka rushewa daga furotin-peptide bangaren, wani aiki sashi daga ciki ruwan 'ya'yan itace da na hanji da enzymes a baka liyafar. Har ila yau, matsalar ta zama wata sabon abu na farko nassi ta hanyar hanta - dauri aiki na hadaddun da ta tukar tumbi.

A bayani da aka samu a cikin yin amfani da injectable hanya na gwamnati da kuma rectal suppositories. Duk da haka, na farko hanya ne daban-daban ga wasu fasaha wuya, da a hade tare da m majiyai. Kuma na biyu da aka ba tasiri isasshen saboda low absorbability a karshe sashe daga cikin dubura. A yanke shawara zo ba zato ba tsammani. An gano cewa intranasal - shi kamar yadda allura, irin gwamnati, a da m farko na warkewa sakamako. Kuma ya kara da wasu related abubuwa da aka bayar, kamar high bioavailability, Ina nufin bukata maida hankali na aiki sashi a shafin na ta aikace-aikace.

Wani amfani da dukiya intranasal gwamnati ya nuna a extracellular (jingine sha a cikin jini ta cikin mucous) shigar azzakari cikin farji na aiki abubuwa a cikin kwakwalwa. Samun kan olfactory yankin, da miyagun ƙwayoyi ne tsĩrar da zaruruwa na olfactory kuma trigeminal jijiyoyi.

Saki suranta intranasal formulations

Don sakawa cikin hanci kogo da ake amfani da quite iyaka yawan pharmaceutical siffofin. Na farko shi ne, ba shakka, da hanci saukad. Zai yiwu inhalation powders tare da kudin tsarin. Amfani da kwanciya man shafawa. Daban-daban mafita ko decoctions na ganye don wanke hanci cavities a cikin wannan kungiyar ba saboda short daukan hotuna da mucosa lokacin da amfani.

Babban nau'i na saki intranasal kwayoyi da ciwon tsari effects ne hanci sprays. Su ake samar a cikin nau'i na dosing canisters tare da matsa iska ko da wani aiki famfo-atomizer. Godiya ga wani juz'i daga watsi feshi a lokacin da guga man sau daya, shi ne mai yiwuwa a gwada controllable sashi daga cikin miyagun ƙwayoyi.

Har ila yau, lokacin amfani da SPRAY ne a ko'ina da ban ruwa hanci mucosa. Wannan kara habaka da sha da miyagun ƙwayoyi da kara habaka ta pharmacological mataki.

Main abũbuwan amfãni daga hanci gwamnati

Bisa ta gabatar ba, yana yiwuwa a gano key falalan mallaki by intranasal formulations. The sauƙi da sauki daga gwamnati, wanda ba ya bukatar ƙarin fasaha kayan aiki da horo, kamar yadda shi ne yanayin da allura hanyoyin su ne quite muhimmanci daga yin amfani da haƙuri.

Tare da Physiology da pharmacology na matsayi a cikin na farko wuri ne da yiwuwar tsakiyar mataki a kan kwakwalwa tsarin. Bayyana tsari sakamako, yana zuwa a cikin gajeren lokaci, kamar yadda a cikin allura Hanyar gwamnati, shi ne kuma muhimmanci. Saboda babu sabon abu na farko nassi ta hanyar hanta, samar da high bioavailability na miyagun ƙwayoyi da kuma kananan adadin hade m halayen.

A disadvantages

Daga cikin ra'ayinsa na tsari sakamako babban matsala ne don kula da warkewa matakin a cikin jini jini taro na miyagun ƙwayoyi. Wajen hanzari tunawa da kai wani ganiya na mataki na wani dan gajeren lokaci, don haka da intranasal gwamnatin iya kawai a yi amfani domin gajere gyara na yanayi. Tsawo sakamako ne kawai zai yiwu a lokacin da gudanar da kwayoyi da cewa suna da illa a kan kwakwalwa tsarin.

Bugu da kari, da zai yiwu ci gaban gida halayen da hanci mucosa. Wannan shi ne saboda a isasshe babban taro na aiki sashi a cikin abun da ke ciki na fesa da abun ciki na ƙarin aka gyara don tabbatar da iyakar nassi na miyagun ƙwayoyi daga surface na mucosa da jini.

Ability sha daga hanci rami ya fairly iyakance yawan kwayoyi tun da ake bukata domin wannan physicochemical Properties. A haƙuri shi ne wani ƙara taro na aiki sashi take kaiwa zuwa gagarumin halin kaka don sayan wani SPRAY.

intranasal immunomodulators

A kashe-kakar ko a annoba colds domin yin rigakafi da magani daga yadu amfani da kwayoyi da kara rura wutar da kuma gida rigakafi tsaron gida.

Domin manufar gaggawa rigakafi da kariya ne amfani intranasal interferon.

Lokacin da mahara karatu sun nuna cewa intranasal hanya na gwamnati na immunomodulators INGANTA ba kawai ya hana a shigar azzakari cikin farji da ƙwayoyin cuta, pathogens ta hanyar hanci mucosa. Yana kuma stimulates m sojojin da kansa - da kunnawa da kansa samar da interferon. Don ta da samar da na ciki interferon tabbatarwa far a matsayin hanyar yin amfani da miyagun ƙwayoyi "Anandina" intranasal.

interferon mutum

A shirye-shiryen da takamaiman rigakafi kariya da ciwon aiki da mafi pathogens kwayar colds, "Interferon" da aka bayar a cikin nau'i na Allunan, injectable shirye-shirye da kuma powders domin shiri na saukad. Domin yin rigakafi da magani, ba za ka iya amfani da duk wani nau'i na release. Amma ga gida kariya fi dacewa intranasally. Wannan, kamar yadda wani shãmaki mai suturcẽwa zai hana shigar azzakari cikin farji daga wani babba adadin cutar a cikin sel mucous membrane na hanci kogo. Wannan zai samar da wani m abin da ya faru a annoba yanayi.

Immunostimulant "Anandina", ido saukad da hanci

A miyagun ƙwayoyi ne yadu used saboda da kusan cikakkiyar babu illa, m halayen da kuma kyau rigakafi stimulatory effects. Bugu da kari, shi yana ma wani pronounced ciwo-warkar da dukiya da cewa yana da muhimmanci a aikace kamar yadda ido saukad da a corneal ko conjunctival rauni.

Contraindications ya kadai ba intramuscularly "Anandina". Hanci saukad da aka yarda a kowane zamani, ciki, lactation da sauran physiological yanayi ko cututtuka.

Idan rashin lafiyan rhinitis

Sau da yawa sa itchy hanci, sneezing da profuse mugunya gamsai zama ba a cutar, da kuma antigen, abu don wadanda ba takamaiman rigakafi martani - allergies. A cikin hadaddun jiyya na wannan nau'i na rhinitis, intranasal corticosteroids sukan yi amfani. Wannan Gaskiya ne, don mutanen da fama da yanayi siffofin alerji - hay zazzabi.

A wasu zamani flowering shuke-shuke, irin marasa lafiya ne kawai arancinsu aikace-aikace antihistaminic kwayoyi kungiyar, wanda a mafi yawan lokuta ya nuna fiye da kuma magani mai kantad da hankali sakamako. Kuma ba ya halatta a karkashin gudanar da Motoci, aiki kayan aiki, ko a cikin yanayi na matsakaicin shafi tunanin mutum da natsuwa. Sa'an nan nada gida hormonal sprays cewa cire bayyanuwar cututtuka ba tare da gagarumin tasiri a kan sauran hormonal auna.

rigakafi

Duk da fadi da kasancewa da sauki portability na wadannan kwayoyi, yana da muhimmanci a tuna cewa intranasal - shi ne, kamar wani, wani magani da ya kamata a yi amfani ne kawai a kan ganin likita, a cikin wajabta sashi na su, multiplicity da tsawon liyafar.

Sau da yawa akwai yanayi a lokacin da za ka ɗauki mahara kwayoyi, soke babu wani daga wanda ba zai iya. Saboda haka, bukatar gano ko za su yi a lokacin da a hade mummunan tasiri a jiki. Umurnai na amfani iya hada dukkan embodiments na rashin lafiyan halayen. Wannan shi ne dalilin da ya sa kafin shan irin wannan na kowa kwayoyi kamar yadda suppositories, man shafawa da kuma sprays, ya kamata ka shakka tuntubar wani gwani.