"Octagam": umarnin don amfani, alamomi, illa

Yana nufin wani magani da kara habaka tsarin na rigakafi, "Octagam". Dokokin za a iya tunawa cewa wannan shi ne wani tsanani miyagun ƙwayoyi, da kuma shi ne ya gabatar kawai a asibiti, tsananin a kan takardar sayen magani. Amfani da maye gurbinsa da kuma immunomodulatory magani.

Form saki da miyagun ƙwayoyi da kuma abun da ke ciki

An samar kawai a cikin nau'i na bayani ga jiko shiri "Octagam". Umarnin a haɗe da shi da kuma shi ne batun m binciken da ake ji. The bayani ne m, tare da yellowish tinge. Da miyagun ƙwayoyi da aka samar a gilashin vials 20, 50, 100, 200 ml, wanda aka rufe da roba marufi da wani aluminum burnishing cushe a cikin wani kwali akwatin, inda a Bugu da kari da umarnin don amfani ne da wani roba-raga mariƙin.

A medicament ƙunshi a 1 ml na akalla 95% immunoglobulin G. The nuna alama ne daidai da adadin furotin kunshe ne a cikin jinin mutum jini. Ƙarin abubuwa a cikin abun da ke ciki na miyagun ƙwayoyi ne:

• maltose.
• octoxynol.
• tributyl phosphate.
• ruwa ga injections.

A miyagun ƙwayoyi ya kamata ba daskare ko bijirar da hasken rana. An adana a zazzabi na 2-8 ° C, da isar yara.

Pharmacology da kuma pharmacokinetics

Drug "Octagam" (manual yayi kashedin game da contraindications kuma zai yiwu sakamakon na yin amfani da kwayoyi) rinjayar da mutum rigakafi da kuma tsarin yana nufin immunoglobulins.

Magani ne a wani ɓangare na immunoglobulin aji G, wanda nuna antibodies zuwa daban-daban dauke da kwayar cutar matakai a cikin jiki. Da miyagun ƙwayoyi ƙunshi subclasses na immunoglobulin G, m ga mutum jini, maimaita duk da kaddarorin da kuma halaye. A gabatarwar da miyagun ƙwayoyi a cikin jiki ya mayar da rage yawan matakan IgG, take kaiwa gare shi to wani al'ada jihar. IgG kwayoyin saboda enzymatic da kuma sinadaran daukan hotuna ba su canza. The aiki na antibodies ya iya gaba daya ajiye.

A shirye-shiryen "Octagam" ba fiye da 3% polymer, da saura ne lissafta ta monomers da dimers ne game da 90%.

Idan ka ƙirƙiri da kayan aiki amfani da jini na 3500 gaba daya lafiya gudunmawa. Antibodies da suke a cikin jini daga wadannan mutane zauna a cikin wannan shiri canzawa da zama cikakken aiki.

Bayan Drug Administration cikin wani jannayẽnsa immunoglobulin G nan da nan ta shiga cikin tsari wurare dabam dabam, wanda aka rarraba tsakanin jijiyoyin bugun gini sarari da jini. A da ake ji da "Oktagama" haƙuri da yanayin inganta a cikin 3-5 days. Samu magani a 24-36 ga watan rana. A rabin rayuwa ne daban-daban ga kowa da kowa da kuma dogara a kan haƙuri ta shekaru, mataki na immunodeficiency. Immunoglobulin G ko wasu rigakafi gidaje dauke da aiki bangaren, halakãsu da reticuloendothelial tsarin.

Lokacin amfani "Octagam"?

Amfani da "Octagam" maye far, idan akwai primary immunodeficiency syndromes, na farko, a nakasar hypogammaglobulinemia, agammaglobulinemia da Wiskott-Aldrich ciwo. Wannan ya hada da m unclassifiable immunodeficiency irin da hada immunodeficiencies.

A nuni ga miyagun ƙwayoyi ne aka yi nufi mahara myeloma, lymphocytic kullum form. Kuma an wajabta, magani ga marasa lafiya da maimaita cututtuka, da kuma cutar HIV a cikin yara.

A magani ya sami yin amfani da hanyoyin kwantar da hankali. Wannan shi ne, shi da ake amfani a idiopathic thrombocytopenic purpura (ITP), tare da wani ƙãra hadarin zub da jini. Har ila yau, da miyagun ƙwayoyi da ake amfani kafin tiyata don normalize platelet count. Kuma an wajabta, magani da Guillain-Barre ciwo. Yana hidima a matsayin nuni ga Kawasaki cuta a cikin yara da manya.

Yi amfani da "Octagam" (User aikace-aikace ya bayyana a cikin daki-daki Hanyar gwamnati da kuma sashi daga cikin miyagun ƙwayoyi) a allogeneic bargo dasawa.

Contraindications don infusions

Yana gargaɗin cewa wajibi ne a yi la'akari da contraindications kafin amfani da "Octagam" shiri umarnin. Kada ka yi amfani da magani a gaban hypersensitivity zuwa ta bijiro da batun kafa abubuwa ko don homologue immunoglobulins.

Tare da matuqar kula sanya marasa lafiya da miyagun ƙwayoyi da suke obese. Bã su da wani predisposition wajen samar da thrombosis. Yana nufin an contraindicated idan akwai wani "ganewar asali da hauhawar jini," da cutar ciwon sukari, cututtuka na zuciya da jijiyoyin jini tsarin, mika zaman ba tare da zirga-zirga, kara a cikin danko na jini.

A lokacin da babban danko jini immunoglobulin, shiga cikin jini, har suka sa hadarin tsokar zuciya infarction, na huhu embolism, bugun jini, venous thrombosis.

Kariya dole ne amfani da wannan magani, marasa lafiya da koda gazawar da kuma marasa lafiya da hypovolemia jurewa magani nephrotoxic jamiái. Idan akwai wani m gwamnati na immunoglobulin-mataki na koda cuta, da "Oktagamom" far aka tsaya.

Marasa lafiya da m na koda gazawar a siffar kazalika da mutane tare da thromboembolic rikitarwa da igiyar jini drip ko allura, da miyagun ƙwayoyi ne gudanar sannu a hankali da kuma a cikin kadan yawa.

Rinjayar da miyagun ƙwayoyi a ciki da kuma lactating mata ba a karatu, don haka da lokaci ya nuna magani ya kamata a yi amfani da tare da matsananci hankali. Duk da wannan, da yi ya nuna cewa yin amfani da immunoglobulins ba ya faruwa wani illar a lokacin daukar ciki. Da miyagun ƙwayoyi yana da wani sakamako a kan tayin da ba zai tasiri a baby ta cikin madarar uwarsa. Immunoglobulins, samun shiga cikin ƙirjinka madara, ba ya haifar da wani lahani ga jariri, da kuma antibodies žunsa aciki, kawai taimakawa ga samuwar karfi rigakafi.

sashi

"Octagam" da miyagun ƙwayoyi ne gudanar kawai intravenously. Kafin fara da za a warmed zuwa dakin da zazzabi, da mafita hanya. The ruwa dole ne gaba daya m, kuma suna da wani precipitate da turbidity.

Kowane Drug Administration aka rubuta a cikin tarihi da cutar. Akwai ma sa magani tsari da lambar kuma sunan. Wannan ne yake aikata to inganta saka idanu na haƙuri da yanayin. Da miyagun ƙwayoyi sauran bayan da jiko, ba za a iya adana kuma dole ne a hallaka.

A farko kudi na gabatarwar sostvlyaet 0.01 zuwa 0.02 ml / kg jiki nauyi a cikin minti daya, da kuma haka a kan for rabin awa. Tare da kyau tolerability medicament kudi a hankali za a iya ƙara zuwa 0,12 ml / kg jiki nauyi da minti.

The adadin miyagun ƙwayoyi da tsawon far an m akayi daban-daban ga kowane haƙuri. Duk abin dogara a kan asibiti martani a wani musamman haƙuri, ya yanayin da ganewar asali daga cutar.

Canzawa immunomodulating far a primary immunodeficiency ya shafi kara yawa na immunoglobulin G zuwa 4.0-6.0 g / l, shi aka auna kafin kowane jiko. Domin cimma wannan adadi za bukatar 3-6 watanni magani. Harufan kashi gwamnati ne 0.4-0.8 g / kg. Daga bisani da miyagun ƙwayoyi ne gudanar ga marasa lafiya kowane makonni uku a 0.2 g / kg. Don cimma manufa immunoglobulin 6.0 g / L, da mãsu haƙuri dole ne a sanya a kan wata-wata 0.2-0.8 g / kg na miyagun ƙwayoyi. Da zarar haƙuri dawo zuwa al'ada jihar, da miyagun ƙwayoyi ya ci gaba da za a gudanar a kowace 2-4 makonni, bayan da aunawa da taro na immunoglobulin G a jini. Wannan zai taimake ka zabi mafi kyau duka sashi.

Canzawa magani far da aka gudanar a kullum lymphocytic cutar sankarar bargo, wanda ya wuce zuwa secondary hypogammaglobulinemia a mai tsanani form, a mahara myeloma, kazalika a cikin ganewar asali "da kwayar cutar HIV" a yara tare da maimaita kuma dauke da kwayar cutar tafiyar matakai. Sashi haka fluctuates kusa 0.2-0.4 g / kg. Multiplicity na gabatarwar - kowane 3-4 makonni.

A lokacin jiyya na m aukuwa na idiopathic thrombocytopenic purpura (ITP) da ake amfani a wani sashi na miyagun ƙwayoyi 0.8-1.0 g / kg lokacin gudanar a rana ta farko. Idan ya cancanta, da sake yin amfani da medicament samar a 2-5 rana a cikin wani adadin 0.4 g / kg. Idan lokuta na exacerbation da cutar sake aukuwa, da miyagun ƙwayoyi ne gudanar sake.

Guillain-Barre ciwo magani ya shafi at 0.4 g / kg daga cikin miyagun ƙwayoyi da rana domin 3-7 kwanaki. A wannan yanayin, da yin amfani da miyagun ƙwayoyi domin yara ne mai iyaka.

Kawasaki cuta a cikin yara da manya bi da tare da wani sashi na 1.6-2.0 g / kg. Da miyagun ƙwayoyi ne gudanar a wannan kashi a 2-5 kwanaki. Yarda guda miyagun ƙwayoyi halitta a cikin wani adadin 2.0 g / kg. A lokacin da gudana magani daga mãsu haƙuri lokaci guda tare da gabatarwar "Oktagama" dole a yi amfani da asfirin.

Immunoglobulin aka yi amfani da bayan allogeneic bargo dasawa shiri magani. Administration na mai magani ya hana abin da ya faru na kamuwa da cuta da kuma ci gaban da ciwo na "dasa a kan rundunar". A sashi ga kowane haƙuri da aka zaba akayi daban-daban. An shawarar fara daga kashi 0.5 g / kg mako. allura hanya ya kamata a fara a mako mai zuwa kafin sashin jiki dasawa. Far ci gaba watanni uku bayan tiyata. Idan akwai wani m rashin immunoglobulins, da magani amfani zuwa 0.5 g / kg kowane wata domin idan dai abun bai dawo al'ada matakan.

illa

Subject to m binciken da ake ji magani "Octagam" umurci manual. A ci gaba da illa a lokacin da yin amfani da miyagun ƙwayoyi dogara a kan kashi da kuma kudi na gwamnati.

Igiyar jini allura da miyagun ƙwayoyi zai iya sa leukopenia, hemolysis da reversible hemolytic anemia. A lura da yiwu korau dauki na rigakafi da tsarin, wanda aka bayyana a cikin bayyanuwar hypersensitivity. A rare lokuta bayyana anaphylactoid da anaphylactic halayen, puffiness na fuska, angioedema.

HIV far a yara da kuma lura da sauran cututtuka sau da yawa yana sa ciwon kai. Yana da rare kwakwalwa cuta daga jini wurare dabam dabam, da} arfin tashin hankali, aseptic meningitis. Da miyagun ƙwayoyi zai iya sa ciwon kai, paresthesia da vertigo.

A lokacin jiyya, akwai yiwuwar samun faru na tsokar zuciya infarction. Akwai iya zama wani ƙara bugun zuciya da kuma tahikradiya. Wani lokaci damu cyanosis, hypotension da thrombosis. Yana da quite rare Sistem insufficiency, zurfin jannayẽnsa thrombosis, hauhawar jini.

Da miyagun ƙwayoyi iya haifar da wani m dauki a kan wani ɓangare na numfashi tsarin. Wannan numfashi rashin cin nasara, na huhu edema, shortness na numfashi. A mummunan sakamakon da aka bayyana, a wani Fit na tari, bronchospasm, na huhu embolism.

A lura zai iya sa tashin zuciya da amai reflex, ciwon mara, da zawo. A rare lokuta, akwai eczema, urticaria kuma itching. A wasu marasa lafiya, bayan ta yin amfani da miyagun ƙwayoyi tashi dermatitis, alopecia, kuma pruritus.

An wuya lura halayen kamar ciwo a cikin mayar da yankin, myalgia da arthralgia. More in magani iya ci gaba koda insufficiency, ta ƙara magani creatinine, damemu zazzabi, matsananci gajiya, rashin jin daɗi dauki faruwa a allura shafin. Daga cikin wanda ba safai ba ne illa events lura jin sanyi, zafi a cikin kirji, flushing, malaise, rash da pyrexia. A rare yanayi, marasa lafiya da low jini, anaphylactic buga.

A bayyanar yiwu illa a marasa lafiya, gwamnati na da miyagun ƙwayoyi a jure da baya da kyau. "Octagam" Yanã da karuwa a hanta enzymes kuma glucose yawa a cikin dakin gwaje-gwaje jini da karatu.

Lokacin da yadda ya kamata a zabi kashi na iya faruwa overdosing bayyanar cututtuka. Yana da kullum ruwa riƙewa a cikin jiki, kara jini danko, wanda aka lura a cikin mutane tare da koda cuta, da kuma a tsofaffi da marasa lafiya.

A duk cikin sama lokuta, symptomatic magani bada shawarar.

tsõratar

A miyagun ƙwayoyi ne iya rage tasirin live attenuated cutar alluran na tsawon makonni shida zuwa watanni uku. Don kauce wa wannan, ya kamata ka jira bayan aikace-aikace na "Octagam" watanni uku na shirye-shiryen. Magani na rage tasiri na kyanda maganin a shekara, don haka kafin staging wannan lamba ya kamata a bari titer kyanda antibodies.

Jiyya tare da wannan magani zai iya sa a yawan illa, haka wajibi ne da matužar bin umarnin ga sashi da kuma gwamnati kudi. A cikin shakka daga far zama dole a kowane lokaci wajen saka idanu da kiwon lafiya na marasa lafiya.

Marasa lafiya da suke gudanar da igiyar jini immunoglobulin, ya sami isasshen hydration kafin hanya, da za su gudanar saka idanu na fitsari fitarwa da kuma jini creatinine. Wajibi ne a gaba daya cire aikace-aikace na "madauki" diuretics.

Idan akwai korau halayen zama dole don rage kudi na Drug Administration ko gaba daya dakatar da yin amfani da shi. A far dogara ne a kan mai tsanani da kuma yanayi na m events. Idan akwai wani bugu, shi wajibi ne don koma ga anti-buga far, wanda ya kamata a hade tare da magani.

Sau da yawa sosai Yanã m halayen m kudi na gwamnati, musamman a hypo- da agammaglobulinemia da ake ji primary immunoglobulin. Side effects na iya faruwa a lokacin da canja wurin mai haƙuri da immunoglobulin daya manufacturer zuwa wani miyagun ƙwayoyi, da kuma idan lokaci mai yawa da ya wuce tun da na karshe jiko.

Control na wadannan marasa lafiya (kuma wannan ya hada da marasa lafiya da} wayoyin cutar HIV matsayi) kamata a da za'ayi ci gaba cikin haila daga cikin na farko jiko na mataki, musamman a lokacin farko da sa'o'i bayan hanya. Marasa lafiya da suke yi ba illa, shi ya kamata a karkashin wani likita ta dubawa bayan jiko "Oktagamom" na farko da minti 20.

A lokacin far kamata dauki misali sauna su hana kamuwa da cutar da suke yiwu a lokacin da yin amfani da magunguna sanya daga jinin mutum ko jini. Wadannan sun hada da zabin da ya dace gudunmawa, sa idanu na mutum servings da jini waha ga takamaiman alamomi na kamuwa da cuta. Wannan tsari ya hada da matakan da inactivation / kawar da ƙwayoyin cuta.

Duk da dukan riƙi shirinsu da magani daga irin wannan kwayoyi, ba za mu iya ware da yiwuwar na canja wuri da dama jamiái na cututtuka, ƙwayoyin cuta da kuma wasu pathogens. Duk na sama da matakan aiki a tabbatar da dalilin da ya wajaba a ƙwayoyin cuta HIV, hepatitis B, kuma C. The kalla su sanin ko dako na parvovirus B19 da gipatita A. Clinical kwarewa da magani jamiái dauke da mutum immunoglobulin da shawara cewa parvovirus B19 da kuma hepatitis A da magani daga kwayoyi ba a daukar kwayar cutar data. Na bayar da muhimmanci a antiviral aminci ne gaban a magani samfurin m antibodies.

A lokacin da nassi daga cikin warkewa Hakika passively canjawa wuri antibodies a cikin haƙuri na jini iya ba ƙarya sakamakon lokacin dauke da fitar serologic gwaje-gwaje. Maltose dauke a cikin shirye-shiryen da yake iya ƙarya karkatar da jini glucose matakin.

Ingantaccen yi a jini glucose taro lura a lokacin kau da miyagun ƙwayoyi daga kwayoyin ko goma sha biyar sa'o'i bayan ta ƙulli. A wannan yanayin, akwai yiwuwar m nufi insulin kashi cewa zai iya tsokana da qarancin ruwa da. Saboda haka, kawai glyukozospetsificheskie hanyoyin kayyade matakin na glucose a cikin jini da za a yi amfani da magani na "0ktagamom". Test kaya for monitoring jini sugar ya kamata su iya sanin wannan siga a marasa lafiya shan magunguna da maltose.

Idan ba ƙare, sai a yarda don adana kwayoyi "Octagam" (50 ml da kuma 100 ml) a zazzabi har zuwa + 25 ° C watanni uku ba tare da sakandare ajiye ta a cikin firiji. Sauran domin a kayyade lokaci, da miyagun ƙwayoyi dole ne a hallaka.

Magani ba ya shafar ikon fitar da su na yin ayyuka da cewa bukatar kulawa ta musamman Al'arshinSa, kuma m psychomotor halayen.

Drug "Octagam": takwarorinsu

Wannan magani yana da yawan analogues da zai maye gurbin shi a cikin hali na bukatar, shi ne:

• "Biaven VI."
• "Veegum-liquidity."
• "Venoglobulin".
• "Gabriglobin".
• "Gabriglobin-IgG».
• "Veegum-C."
• "Gamunex."
• "Gamma Globulin Hooman".
• "IG Vienna N.I.V. ".
• "Imbioglobulin".
• "Immunoglobulin".
• "Imbiogam".
• "Immunovenin".
• "Intratekt".
• "Sandoglobulin".
• "Endobulin".
• "Flebogamma 5%."
• "Humaglobin".

Rasha musanya su da yawa mai rahusa fiye da su waje takwarorinsu. A cikin wani hali, duk wadannan kwayoyi ne m isa ya karba da kuma dole ne a maye gurbin kawai da wani likita, dangane da haƙuri da yanayin.

"Octagam" Medicine: farashin

A kudin da miyagun ƙwayoyi ne quite high. Yana za a iya saya don 9,5-12 dubu rubles da kuma 50 ml da miyagun ƙwayoyi "Octagam". 100 ml Price ne a kusa da 20-24 dubu rubles.

Da ra'ayoyi da marasa lafiya da kuma likitoci

Drug "Octagam" yana da sake dubawa kagaggun tabbatacce. Musamman godiya ta ingancin mutane, wanda ya taimaka wajen mai da tare da immunodeficiency da Guillain-Barre ciwo. An sau da yawa amfani ga mutane da AIDS kula da su lafiya. Ya tabbatar da tasiri a kullum lymphocytic cutar sankarar bargo, myasthenia gravis. Mata na amfani da wannan magani don zama ciki kuma kai yaro.

Mafi yawa daga cikin marasa lafiya m tare da kudin da miyagun ƙwayoyi, da suka lura da cewa yana da wuya a saya a Pharmacy. Wasu kira shi da wani rauni, ciwon kai, da kuma janar malaise.

Likitoci suka ce cewa shi ne m shiri, shi ne da samamme ta jiki, da kuma sabanin m immunoglobulins m iya sa allergies.