Antibodies zuwa biyu-stranded DNA - musamman norms da kuma Mabudi

Anti-dsDNA (antiDNK) ko biyu-stranded DNA antibodies ne iri-irin rukuni na antibodies da biyu-helical DNA, kazalika a dakin gwaje-gwaje alamomi na SLE (na tsari lupus erythematosus).

Autoantibodies da DNA, wadda aka gano a cikin nucleus din an kira antibodies zuwa biyu-stranded DNA. A daidai dalilin da bayyanar a cikin jini gano ba.

Mene ne wani antibody?

The mutum rigakafi da tsarin samar da antibodies, da ake kira musamman sunadaran da yãƙi daban-daban parasites, ƙwayoyin cuta, fungi, kwayoyin cuta, watau tare da kasashen waje abubuwa a kan kwayoyin matakin. The aiki ya hada da wani antibody ya hallaka waje abu da kuma ba ya taba da 'yan qasar Kwayoyin, kira kai-haƙuri inji.

Akwai lokuta idan na rigakafi da martani ne directed da kansa tsokoki da Kwayoyin, ba waje. To, akwai ci gaban da wani autoimmune cuta, da kuma antibodies samar gāba da kansa Kwayoyin da su gyara, masana kira autoimmune.

Idan taron na tsanani "gazawar" na rigakafi, ta ƙara matakan autoantibodies, wanda shi ne quite isa ga staging da haƙuri ganewar asali.

Antibodies zuwa biyu-stranded DNA - antibody ba daya, amma a dukan kewayon su, wanda shi ne mai DNA manufa cell tsakiya.

Antibody gwaji ne sosai m ga ganewar asali na SLE, watau, sakamakon tabbatacce iya magana game da tabbaci da ganewar asali. A 70-80% na lokuta, marasa lafiya aka danganta daidai wannan bincike. Duk da haka, saboda da kasa ýan na bincike na bukatar babban kula a lokacin da karanta gwajin sakamakon, kamar yadda idan sakamakon ne na musu shi ne, ba da gaskiya cewa haƙuri ba shi da SLE.

Wadannan kima sau da yawa nada rheumatologist. Amma shi za a iya rubuta shugabanci da kuma a ilimin, da kuma nephrology, kuma dermatology. Duk abin da zai dogara ne a kan abin da gwani jawabi haƙuri da farko. Immunological dakin gwaje-gwaje - wannan shi ne wurin, inda ya gudanar da bincike a kan antibody. Musamman shiri domin bincike ba dole ba ne.

SLE - tsari Lupus Erythematosus

SLE ne mai tsanani autoimmune cutar da ke shafar mahara sashin jiki da tsarin (tsarin na kwakwalwa, fata, kodan, gidajen abinci, jini da kuma zuciya). A lokaci daya gaban bayyanar cututtuka a duk jikin da aka ba da ake bukata. Bayyananen na lupus ne quite bambance bambancen: mutum daya zai fi fata cututtuka, da sauran, misali - koda.

Antibodies 'yan kasa biyu-stranded DNA nufin taimakawa wajen gano cutar.

Hadarin dalilai don tsari lupus erythematosus

• Hormonal canje-canje (haihuwa, ciki, haila), wanda ya tashe prolactin da estrogen, wanda ya bayyana da mafi girma kudi na 90% na cututtuka tsakanin mata.
• A predisposition zuwa kayyade matakin, wanda ya tabbatar da kasancewar zumunta na marasa lafiya fama da SLE low matakan da wasu antigens na Hla tsarin da autoantibodies.
• Kwayoyi - "methyldopa", "Procainamide," "Hydralazine".
• Kwayar cutar triggers da autoimmune tafiyar matakai.
• Solar radiation (hasken ultraviolet sa fata Kwayoyin zuwa apoptosis danda DNA, kuma ta zama a bayyane ga tsarin na rigakafi).

Analysis na antibodies zuwa biyu-stranded DNA ne sosai m.

symptomatology na SLE

Common fasali na bayyananen iya kira kumbura Lymph nodes, wani rauni da gajiya, zazzabi, nauyi asara, hadin gwiwa zafi, da kuma tsoka.

• Lupus nephritis ko na koda gazawar (koda aiki da kuma rage akwai wani triad na bayyanar cututtuka dakin gwaje-gwaje).
• Amosanin gabbai da kuma arthralgia, haddasa kumburi da kuma soreness a cikin gidajen abinci na wuyan hannaye, hannuwa, wanda ya nuna wani X-ray raguwa a kashi yawa a kusa da hadin gwiwa (periarticular osteoporosis), duk da haka, ba zai erosions.
• Serositis, cewa shi ne kumburi da serous membrane na zuciya da kuma huhu (pleurisy, pericarditis).
• Photosensitivity, haddasa worsening da cututtuka bayan daukan hotuna da rana.
• Rash, ciki har da a kan fuskarsa, da malam kurji. Antibodies zuwa biyu-stranded DNA aka samu zama dole.

• nephritic ciwo - 45-65%.
• Microscopic hematuria - gaban 80% na ja da maikacin jini a cikin fitsari laka.
• Proteinuria ake dangantawa da asarar gina jiki a cikin fitsari a juz'i na fi 0.5 g / s, Ina nufin 100%.
• Very rare a fitsari gagarumin adadin leukocytes (pyuria), musamman in babu urinary fili cututtuka.

• Retinal auduga-kamar Aljihuna kafa ma ta kumbura da na gani papilla.
• A gaban m lupus pneumonitis, huhu lalacewa, tari da zazzabi tarayya, tare da wakewake alveolar infiltration.
• Bayyananen na neuropsychiatric yanayin jere daga ciki da kuma kawo karshen tare da epileptiform paroxysms, psychosis da na gani ciwon.

A gano wani haƙuri da SLE antibodies zuwa biyu-stranded DNA ake bukata ta hanyar maimaita iko 1-3-6-12 watanni. Ya dogara da tsanani da cuta. A cikin wadannan marasa lafiya na kara hadarin koda lalacewa, saboda antiDNK gidaje tare da rigakafi da gidaje kai ga koda lalacewa.

analysis antiDNK

Wannan bincike ne zama dole:

• Don hango ko hasashen magani nasara.
• Lokacin da ake zargin shi ne akwai wani tsari autoimmune cuta.
• Lokacin da sakamakon ENA antibody bincike tabbatacce antinuclear antibodies.
• Lokacin da bayyanar cututtuka na SLE ne ba.
• Lokacin da ake zargin kasancewar wani tsari cuta, musamman SLE.
• Domin da bambanci ganewar asali articular ciwo.
• Lokacin da gwajin sakamakon haka ne tabbatacce antinuclear antibody.
• Don hango ko hasashen ci gaban koda lalacewa.
• Don sarrafa kwarara daga m kudin.

Abin da ya faru ga wani mutum a lokacin da ya ɗaukaka antibodies zuwa biyu-stranded DNA?

Symptomatology for kayyade antiDNK

• Karuwan jiki zafin jiki, Lymph nodes, rage nauyi, gajiya bayyana.
• Amosanin gabbai, kumburi daga cikin gidajen abinci, bayyana kumburi, da jin zafi, zazzabi a cikin wannan yankin, reddening na fata da kuma motsi cuta.
• Lokacin da atypical tabin hankali da kuma neurological bayyanar cututtuka.
• Lokacin da pleurisy ko pericarditis na unknown asalin.
• Lokacin da Raynaud ta ciwo, watau, wani lokaci-lokaci canji a cikin launi na yatsunsu da yatsun (redness, kodadde, blue), a take hakkin su ji na ƙwarai kuma zafi.
• Koda cututtuka da ciwon da wani rigakafi ko Farawa canje-canje fitsari bincike da sakamakon (hematuria, proteinuria).
• Lokacin da fata cututtuka - thickening na fata, rashes, musamman bayan sunbathing.
• Hemolytic anemia, halakar ja jini Kwayoyin a mafi girma matakan da bilirubin a cikin fitsari da kuma jini.
• Lokacin da neutropenia, rage neutrophil leukocyte dabara.
• Lokacin da thrombocytopenia, rage a cikin yawan platelets a cikin jini.

Antibodies zuwa biyu-stranded DNA: al'ada

Yadda aka saba, da bincike sakamakon ya zama korau, da kuma taro na 0-25 Iu / ml.

Idan sakamakon ne tabbatacce, za mu iya ce: primary biliary cirrhosis. SLE. dauke da kwayar cutar mononucleosis. magani tasiri (SLE a gafarta musu). kullum hepatitis B, kuma C. Sjögren ta ciwo. gauraye connective nama cuta.

Biyu-stranded DNA da antibodies (IgG da IgM immunoglobulins) ya samar da wani rigakafi hadaddun. Ya haddasawa wasu cututtuka halayyar SLE.

Idan sakamakon ne na musu, magana game da lupus miyagun ƙwayoyi ko rashi na SCR.

Wanda rinjayar da sakamakon bincike?

• High rates antiDNK dangantawa da lupus nephritis, exacerbation na cuta ko rashin iko a kan cutar.
• Low rates antiDNK hade da tasiri na far da nasara daga mataki na cuta gafarta musu.
• AntiDNK ne takamaiman nuna alama na SLE, amma kuma za a iya lura a wasu cututtuka (autoimmune, kullum hepatitis C da B).
• Idan antiDNK ba, wannan ba ya ware da ganewar asali SLE.
• Ganewa antiDNK haƙuri ba tare da wani bayyanar cututtuka da kuma sauran sharudda na cuta ba a bi a cikin ni'imar da kafa da ganewar asali SLE.

muhimmanci lura da

A jini gwajin for antibodies zuwa biyu-stranded DNA da aka gudanar a tare da tare da bin nazarin:

• beta-2-microglobulin.
• janar jini bincike.
• antitsentromernymi antibodies.
• janar bincike na fitsari.
• antigistonovymi antibodies.
  

• Hanta aiki gwaje-gwaje (alkaline phosphatase, bilirubin, GGT, AST, Alt).
• Revmoproby (Aso, C-amsawa gina jiki, rheumatoid factor, erythrocyte sedimentation rate).
• tsitrullinovomu antibody peptide (anti-CCP).
• Antinuclear antibodies (ANA). Ne mafi kyau-karatu autoantibodies tare da rheumatoid factor. Yana da aka gano a shekarar 1957, kuma a lokaci guda, masu bincike sun tabbatar da dangantaka da SLE. Kamar wancan antibodies zuwa biyu-stranded DNA ciyar;

• anti-SSB kuma anti-SSA antibodies.

• anti-SCL-70 antibodies.

• anti-nRNP antibodies.

• anti-SM antibodies.
• anti-sp100 antibodies.

Biyu facts game antiDNK

Bugu da kari, antiDNK bayyana a cikin jini saboda wadannan dalilai:

• mahara myeloma.
• SLE ganewar asali rarrabẽwa na wanda shi ne ya samu wani m sakamako na gudanar da bincike.
• pravovirusnoy kamuwa da cuta.
• miyagun ƙwayoyi inutsirovannoy SLE.
• HIV.
• Sjögren ta ciwo.
  
• cytomegalovirus kamuwa da cuta.
• Sharp ciwo (Mixed connective nama cuta).
• dauke da kwayar cutar mononucleosis.
• rheumatoid amosanin gabbai.
• primary biliary cirrhosis.
• tsari sclerosis.
• hepatitis C cutar.
• kwayar hepatitis B.

Saboda haka, jini ga antibodies zuwa biyu-stranded DNA dauki quite sau da yawa.