Da miyagun ƙwayoyi "Baraklyud": umarnin don amfani, description, abun da ke ciki da kuma sake dubawa

"Baraklyud" yana nufin anti-retroviral kwayoyi, kashi na rukuni na nucleoside analogues. Kuma an wajabta, domin lura da kullum HBV-kamuwa da cuta. The aiki sashi daga cikin miyagun ƙwayoyi entecavir sauri cike kwayar kwafi na hepatitis.

Yana dole ne dole a yi karatu annotation kafin shan miyagun ƙwayoyi. Kamar yadda aka nuna ta umarnin don amfani? "Baraklyud" (Baraclud) - wani magani wanda aka yi nufi ga fara da backflow na fibrotic matakai a marasa lafiya tare da hanta cirrhosis.

da miyagun ƙwayoyi

A miyagun ƙwayoyi ne samuwa a biyu sashi zabin - 0.5 da kuma 1 MG entecavir aiki bangaren gani dabam-dabam a fenti launi (fari, ko ruwan hoda, bi da bi).

A shirye-shiryen ma ya hada da:

• polysorbate.
• magnesium stearate.
• lactose monohydrate.
• Valium.
• povidone.
• colorant Opadry.

pharmacological effects

The aiki sashi ne entecavir wanda shi ne wani analogue na nucleoside guanosine, ya furta zabe aiki to hepatitis B.

Entecavir aka phosphorylated zuwa wani aiki triphosphate da rabin-rai na game da 15 hours, da kwayuka abun ciki na wanda aka alaka da taro na entecavir waje Kwayoyin. A lokacin da wannan ba ya lura appreciable jari na aiki abu a cikin jiki. Medicine "Baraklyud" umarnin don amfani wanda ya nuna ta high dace, sannan ya takure na ayyuka na kwayar polymerase, impacting lokaci guda a kan uku dalilai:

• kira na tabbatacce tufka na DNA HBV.
• baya kwafi na korau thread pregenomic mRNA.
• HBV priming enzyme.

Triphosphate ba mai karfi retarders enzymes salula DNA, ko da wani gwaji abun ciki na wani sakamako a kan mitochondrial DNA kira.

sakamako daga cikin miyagun ƙwayoyi

The aiki miyagun ƙwayoyi abu ne iya wani gajeren lokaci a iya tunawa daga narkewa kamar tsarin, kuma ya kai matsakaicin na da abinda ke ciki a 30-90 minti bayan shan Allunan.

Jinsin karuwa a Cmax shiyya da sauran fihirisa auku a m amfani da 0.1-1 MG na medicament "Baraklyud". Umurnai na amfani magana game da cimma wani ma'auni a cikin 6-10-th ranar guda kashi na da miyagun ƙwayoyi a kowace rana. Amfani da m abinci muhimmanci dagula entecavir sha tsari, subtracting lambobin Cmax shiyya da sauran ta 45% kuma 20% bi da bi.

Da miyagun ƙwayoyi ne hanzari tunawa a cikin nama da kuma ta 13% daure su jini sunadaran. The aiki miyagun ƙwayoyi bangaren ne ba zartar da substrates, enzyme hanawa ko inducers na P450 tsarin. Shi ne iya tara a cikin jiki da kuma fitarwa ta hanyar da na koda tsarin da glomerular tacewa da kuma tubular sallama.

alamomi

Medicament "Baraklyud" da shawarar a yi a hadaddun jiyya na hepatitis B:

• Tare da na yanzu bayyanar cututtuka na kwayar kwafi da karuwa daga cikin mataki na aiki da transaminases a magani, a gaban histological manifestations na gudana kumburi na hanta.
• Unrecovered hanta raunuka.

Muhimmanci da taimako na cutar hanta cututtuka faruwa bayan Drug Administration "Baraklyud". Allunan umurci manual bada shawarar cewa marasa lafiya da kullum hepatitis B, hanta da cutar wuya da wadannan:

• located decompensated.
• pathological hanta yanayin a wata diyya mataki lokacin da shigar kwayar kwafi kamu manifestations na hanta fibrosis tare da ƙara AST da Alt.

contraindications

Da miyagun ƙwayoyi "Baraklyud" yana da wadannan contraindications:

• ya karu laulayi entecavir da sauran abubuwa kunshe a da miyagun ƙwayoyi abun da ke ciki.
• hereditary lactose rashin ha} uri, glucose-galactose malabsorption, rashi ko rashi a cikin jiki na enzyme lactase .
• shekaru kasa da shekaru 18.

Mutane da koda gazawar bukatar dauki da miyagun ƙwayoyi a kan sayan magani da kuma a karkashin m likita dubawa.

Yanayin aiki "Baraklyuda" a lokacin daukar ciki ba da shawarar a lokacin far bukatar dakatar nono.

illa

Akwai tsammãninsa ya zama iri-iri na cuta na narkewa kamar tsarin lokacin miyagun ƙwayoyi jiyya "Baraklyud". Umurnai na amfani ne a fili da aka bayyana illa:

• narkewa kamar cuta.
• zawo.
• tashin zuciya da kuma amai.
• dyspepsia.

Zaka kuma iya samun ciwon kai, rashin barci, ko drowsiness, asarar ci, da kuma rashin lafiyan halayen.

Da ake ji magani a matsayin tafin kafa warkewa wakili ko a hade tare da sauran maganin kwayoyi na iya sa mai tsanani hepatomegaly da steatosis, wanda na iya haifar da haƙuri ta mutuwa.

A marasa lafiya da decompensated view laktatsiadoz raunuka iya faruwa hanta, wanda aka halin:

• janar tsoka rauni.
• m numfashi da kuma bayyanar shortness na numfashi;
• tashin zuciya.
• gagarumin raguwa na jiki nauyi.
• zafi a cikin peritoneum, epigastric.

Har ila yau, da miyagun ƙwayoyi zai iya sa daban-daban da kuma halayen jiki:

• ya karu rates na hanta transaminases.
• fata rash.
• anaphylactoid dauki.

A marasa lafiya ma fama decompensated cutar hanta, a Bugu da kari, irin wannan halayen ne bayyana kwayoyin:

• koda gazawar (a rare lokuta);
• ya karu bilirubin abun ciki a cikin jini.
• . Ragewan na platelet count zuwa 50 dubbai / mm ³ ko kasa;
• akan rage bicarbonate a cikin jini.
• karuwa da Alt.
• fiye da uku-Musulunci karuwa a cikin ayyuka na lipase.
• rage matakan albumin.

Medicament "Baraklyud": Sashi da kuma gwamnati

A miyagun ƙwayoyi ya kamata a dauka a kan komai a ciki, lokacin da zamani daga karshe ci abinci kafin dosing ya zama fiye da sa'o'i biyu.

Lokacin cika hanta lalacewar shawarar liyafar "Baraklyuda" 0.5 MG kullum. A gano jure lamivudine sashi ya kamata a ninki biyu.

Marasa lafiya da hanta raunuka unrepaired wajabta kullum ci na 1 MG. Ga tsofaffi da marasa lafiya da na koda insufficiency, da kashi ya kamata a gyara dangane da matakin da CK (creatinine taro) a cikin jini.

yawan abin sama

Bayani a kan lokuta da miyagun ƙwayoyi yawan abin sama bai isa ba.

Agaji, wanda aka asibiti gwada, karbi kullum sashi na 20 MG ga makonni biyu da aka ba su guda mafi girma kashi - 40 MG miyagun ƙwayoyi "Baraklyud". Umurnai na Amfani furta cewa, illar da aka gano.

Shawarar posindromnoe magani a karkashin kulawa da na asibiti manifestations.

Hulda da sauran kwayoyi

Saboda gaskiya cewa aiki bangaren entecavir aka excreted da farko ta hanyar koda tsarin, hadaddun far a hade tare da sauran kwayoyi da samar kai tsaye ko kaikaitacce effects a koda aiki da shafi tubular mugunya, na iya haifar da wani karuwa a jikin entecavir da aiki abubuwa na kwayoyi.

Hulda "Baraklyuda" tare da adenovirom, tenofovir, lamivudine aka ba rubuta ba.

rigakafi

Yarda da miyagun ƙwayoyi marasa lafiya resistant zuwa lamivudine take kaiwa zuwa hadarin tasowa juriya.

Har ila yau, akwai shaidar da ya faru na exacerbations na hepatitis B bayan an daina miyagun ƙwayoyi "Baraklyud". Umurnai na amfani bayyana taimako na exacerbations ba tare da ƙarin far.

tsõratar

Yanayin aiki "Baraklyuda" a cikin tsarin na monotherapy da kuma hada magani tare da sauran maganin jamiái, zai iya sa lactic acidosis, hepatomegaly da steatosis. A wannan yanayin, akwai wani hadarin mutuwa.

A hadarin marasa lafiya sun hada da wadannan Categories:

• fama da hepatomegaly.
• da za a bi da yin amfani da nucleoside analogues.
• da ciwon kiba.
• mace marasa lafiya.

Umurnai na yin amfani da miyagun ƙwayoyi "Baraklyud" Notes da yiwuwar samuwar resistant kwayar damuwa. Aiki sashi entecavir miyagun ƙwayoyi ba da shawarar domin lura da mutum immunodeficiency cutar saboda ta yadda ya dace a cikin wannan shugabanci ba tukuna karatu a cike.

A lura da marasa lafiya da Pathology na koda tsarin, wajibi ne a gyara cikin kashi.

A aminci da kuma tasiri na amfani da "Baraklyuda" domin lura da marasa lafiya bayan hanta dasawa suna ba da aka sani da kuma bukatar kula na musamman yarda da matakan.

Storage yanayi da kuma kudin

Storage da kuma harkokin sufuri na katsin kamata a da za'ayi a cikin zazzabi kewayon 15-25 ° C. A shirye-shiryen ne Fit domin amfani na tsawon shekaru biyu daga ranar yi.

Da miyagun ƙwayoyi ne a hada a raba kungiyar na da muhimmanci magunguna, da kuma saboda wasu nau'i-nau'i daga 'yan asalin kafa free bayarwa da miyagun ƙwayoyi "Baraklyud". Umurnai na amfani na kama da wannan hujja.

Price nufin a Moscow Pharmacy yana farawa daga 12 dubu. Rubles.

Views da marasa lafiya

Yana nuna babban inganci daga cikin miyagun ƙwayoyi "Baraklyud" umurci manual. Price, reviews na wanda ya nuna cewa shi ne mulkin demokra] iyya a kwatanta da analogues da miyagun ƙwayoyi, dabam tsakanin 12-17 dubu da kunshin, a cikin abin da 30 katsin. Wannan ya sa da miyagun ƙwayoyi a Popular kuma a bukatar tsakanin marasa lafiya domin lura da hepatitis B.

A korau feedback yafi ake magana proitvopokazaniya da kuma gefen sakamakon da miyagun ƙwayoyi, kamar rashin barci, da kuma tashin zuciya.