DNA methylation: wani bayyani

Methylation ne da shiga na daya carbon da uku hydrogen atoms zuwa wani sunadarin. Wannan sabon abu ne a dauke su da karshe kalma a harkokin kiwon lafiya. Ya bi da aiwatar da kusan dukan jikin ayyuka.

ayyuka

Methyl kungiyoyin (carbon da hydrogen atoms) suna da hannu a:

1. Jiki ta mayar da martani ga stressful yanayi.
2. Ci gaba da kuma aiki na glutathione. Yana abubuwa a matsayin key antioxidant a cikin jiki.
3. Detoxification hormones, nauyi karafa da kuma sinadaran mahadi.
4. Sarrafa mai kumburi tafiyar matakai.
5. Gyara lalace Kwayoyin.
6. Rigakafi da martani da kuma tsari da ƙwayoyin cuta da cututtuka, yin iko da T-Kwayoyin.

. Daidai da muhimmanci ne tsari na DNA methylation. Bari mu yi la'akari da shi a cikin mafi daki-daki.

Epigenetic iko da

способствует передаче паттернов следующему поколению клеток при митозе. DNA methylation alamu facilitates da canja wurin da na gaba ƙarni na Kwayoyin a mitosis. In mun gwada kwanan nan, an gano cewa, aiwatar da shiga kungiyoyin na kwayoyin halitta a cikin terminally-bambanta Tsarin yana da wasu dangane da samuwar ƙwaƙwalwar ajiya da kuma synaptic plasticity. K. Miller da kuma D. Sweet diddigin DNA methylation. Nazarin sabon abu kai su kammala da cewa, aiki na methyltransferase dezoksiribonukleinovokislotnoy muhimmanci ƙara a lokacin da dabbobi haddacen sabon bayani. Wannan taimaka rage magana da kwayoyin halittu da kashe ƙwaƙwalwar tafiyar matakai. Bugu da kari, da mawallafa nuna wata abu. Da masu bincike rahoton cewa furotin reelin gene kunnawa, da inganta canji da kuma synaptic sadarwa hannu a cikin pathological hanya na schizophrenia rinjayar memory samuwar. Lokacin da wannan factor ne sharadi demitalazy-enzymes samar da DNA demethylation (saki daga methyl kungiyoyin). Kafa facts take kaiwa zuwa wani muhimmin ƙarshe. , а также обратное ему явление, играют существенную роль при хранении информации и запоминании. DNA methylation matsayin daya daga cikin epigenetic sunadaran, kazalika da kishiya sabon abu, wasa da wani muhimmanci rawa a bayanai ajiya da žwažwalwar ajiya. Wannan ra'ayin da aka tabbatar da sakamakon binciken kungiyar E. Costa. An gano cewa demitilirovanie reelin da glutamate decarboxylase genes za a iya sharadi beraye kananan kwayoyin da cewa tsoma baki tare da shuka DNA a tsakiya. Wadannan nazarin nuna ba kawai da yiwuwar canza data kasance ra'ayoyi game da samuwar žwažwalwar ajiya. является динамическим. Su ma na nuna gaskiyar cewa a baya tunani m DNA methylation ne tsauri. Haka kuma, shi za a iya amfani da a far.

Features

имеют определенную связь, нельзя назвать новой. Da ra'ayin cewa ƙwaƙwalwar ajiya da kuma DNA methylation da wani dangantaka, ba za a iya kira sabon. An riga an kafa conditionality synaptic watsa histone acetylation. Su samar da kwarangwal a kan wanda DNA aka rauni. Acetylation rage dangantaka da histone zuwa nucleic acid. Wannan yana buɗewa samun DNA da sauran sunadaran alaka, Inter Alia, da kunnawa da kwayoyin halittu. A gaskiya ma, cikin histone aiki atsetilotransferaznaya CREBBP (dauri gina jiki), aiki a matsayin key kwafi factor neurons aka hade da sakamako na wannan gina jiki a kan haddar. Bugu da ƙari kuma, shi da aka saukar karawa m hali memory a lokacin da yin amfani da histone deacetylase hanawa. Yana haifar da wani hanzari na histone acetylation.

shiriritar

Sweet da Miller tambayi wadannan tambayoyi tare da girmamawa ga histone-dogara danniya na magana alamu. ? Idan iya taka rawa a gudãnar memory, za ta kai ga wannan sakamako ko DNA methylation? Wannan sabon abu da aka gani da farko a matsayin wajen rike aiki a lokacin mitosis da kuma Tsarin kafa tsarin. Duk da haka, a cikin dabbobi masu shayarwa kwakwalwa balaga da lura tsanani methylases, duk da cewa mafi yawan Kwayoyin aka nondividing. Saboda gaskiya cewa dauke sabon abu na taimaka wa danniya na gene magana, masu bincike sun iya yin watsi da sadarwa yiwuwa methylase da tsaiko matakai a neurons.

dubawa da zaton

этого явления в формировании памяти, обрабатывали срезы гиппокампа ингибиторами дезоксирибонуклеинокислотных метилтрансфераз. Zaki da kuma abokan aiki daga nazarin methylation na DNA, da muhimmancin wannan sabon abu a cikin samuwar ƙwaƙwalwar, hippocampal yanka bi da tare da mai hanawa dezoksiribonukleinokislotnyh methyltransferases. Sun gano cewa, shi ya hana a farkon dogon lokacin da potentiation - da tabbatarwa daga synaptic sadarwa a mayar da martani ga neuronal aiki. Wannan tsari yana sa da sakamako na koyo da kuma memory sunadaran. Masana kimiyya sun kuma gano cewa, mai hanawa rage matakin na methylation a DNA reelin. Yana nuna ta zuwa ga reversibility.

gwaje-gwajen

Yanke Shawara je kara a da karatu, Sweet da Miller ya fara saka idanu da canje-canje a cikin methylation juna a cikin beraye a wani samfurin a cikin abin da dabbobi koyi shirki wani takamaiman wuri tare da m samuwar kasashe, musamman, rauni tunkaro. Halayyar gwaji samun hanawa, ya bayyana yiwuwar koyo wahala. Samu kansu a wani halin da ake ciki inda suka yi zama a tsoro, da suka bayar da umarnin rike muhimmanci kasa da kula da dabbobi.

binciken

Yadda methylation zai iya shafar memory na beraye? Masana kimiyya sun bayyana wannan kamar haka. A DNA ne ba mai yawa rabo wanda zai iya shafar shiga kungiyoyin na hydrogen da carbon atoms. A wannan batun, da masu bincike ya yanke shawarar amfani da wadannan sabon abu. Sun yi karatu da farko methylation kwayoyin halitta wanda rawa a cikin samuwar žwažwalwar ajiyar an riga an kafa. Ya aka farko dauka up wani yanki a kan abin da furotin phosphatase memory tafiyar matakai an suppressed. rage magana iya haifar da kishiyar sakamako. Lalle ne, sa'a daya na motsa jiki kunsa tsoro methylation matakin ya karu fiye da sau ɗari. A wannan yanayin, da mRNA matakai a hippocampal CA1 yankin hõre wani rauni, amma ilimin kididdiga gagarumin raguwa. Wannan sakamako da aka samu a cikin kwakwalwarmu dabbobi tare da hade da na kananan tunkaro ga extremities da kuma mahallin da sabon abu. Dabam, wadannan ihisani ba samar da wani sakamako a kan methylation. Haka kuma, da shiga kungiyoyin ne da za'ayi na musamman tare da m koyarwa.

DNA methylation da kuma tsufa

Matsaloli na shekaru da kuma bayyanar da ciwon daji na daya daga cikin mafi tattauna batutuwa. Fiye da shekaru masu yawa na gudanar da bincike, masana kimiyya sun nuna wani iri-iri theories da kuma model. Duk da haka, ba manufar a wannan lokacin ba ya amsa da cikakken to duk tambayoyi. A halin yanzu, mafi girma sha'awa a cikin search for mafita shi ne nazarin tsufa canje-canje a gene aiki. A musamman, ta ra'ayi a kan al'amarin bayyana Farfesa Anisimov. Ya nuna cewa, bayyanuwar (magana) kwayoyin halitta shi ne dogara, a tsakanin sauran abubuwa, da methylation, wanda zai iya shafar kudi na tsufa. Har zuwa 5% na saitosin sharan na deoxyribonucleic acid da aka shiga kungiyoyin na carbon da hydrogen atoms ta samar da 5mTs (5-methylcytosine). Wannan tushe ne dauke su ne kawai m, a cikin DNA na mafi girma kwayoyin. Shiga kungiyoyin faruwa a duka biyu strands symmetrically. Zauna 5mTs ko da yaushe boye a baya da Bibyun sharan. A wannan tsarin da daban-daban ayyuka. Duk da haka, yana da muhimmanci a lura da cewa methylation ne da hannu a cikin tsari na gene aiki. Canje-canje a cikin shakka daga shiga kungiyoyin ne ya sa ta kasawa a cikin matakin na kwafi.

dalilai

Age-demethylation aka farko aka bayyana a cikin shekara ta 1973. Wannan bambancin da aka gano mataki na rabuwa da kungiyoyin a bera kyallen takarda. A cikin kwakwalwa, demethylation tafi mafi rayayye fiye da a cikin hanta. Yana aka baya m 5mTs ƙi da shekaru a cikin huhu, kazalika da fibroblast fata tsarin. Da masu bincike da shawarar cewa shekaru-demethylation predispose Kwayoyin to m canji. Wannan sabon abu za a iya bayyana a cikin sauki sharuddan kamar haka. An m gene aka guda biyu zuwa methyl kungiyar. Ƙarƙashin rinjayar da sinadaran halayen faruwa ta cire. Haka kuma, da gene aka kunna. Group yi aikin ayyuka na atoms fis. Karamin da lambar, da more bambancin Kwayoyin da haka girmi su more - saboda haka yana da ƙaramin. A classic misali ne yadu amfani a cikin wallafe-wallafe, zai iya haifar da ci gaban da wasu jinsunan kifi. A sabon abu na musamman m mutuwa nan da nan bayan spawning. Jiya har yanzu matasa mutane na haihuwa shekaru mutu a cikin wani gajeren lokaci. A nazarin halittu shirin, wannan sabon abu ne kara tsufa, wanda yana tare da manyan sikelin-DNA demethylation.

Ta yaya za a taimaka wa jiki?

Akwai hanyoyi daban-daban da wanda inganta m DNA methylation. Daga cikin mafi m ya kamata a kira:

1. Cin sabo ne ganye. leafy kayan lambu ana musamman da shawarar. Suna aiki a matsayin tushen folic acid da ake bukata don tabbatar da ya dace methylation.
2. Vitamins B12 da kuma B6, riboflavin. Su kafofin ne qwai, kifi, almonds, walnuts, bishiyar asparagus da sauransu.
3. Karbar Yã isa zama adadin tutiya da magnesium. Sun bayar da goyon baya methylation.
4. Kudin shiga probiotics. Su taimakawa da shirye-shiryen da kuma sha na bitamin B kungiyar da kuma folic to-ku.

Yana da muhimmanci domin rage danniya, ba up miyagun halaye (barasa amfani, shan taba). Kula ya kamata a dauka don haka cewa jiki ba su samun mai guba abu. Wadannan mahadi dauki methyl kungiyoyin ɗora Kwatancen hanta.