Kwayoyin "Linezolid": umarnin don amfani, farashin takwarorinsu, da saki tsari da kuma sake dubawa

Mafi yawa daga cikin san magani kwayan ko kwayar cututtuka amenable don magani da na al'ada kwayoyi. Duk da haka, akwai pathogens cewa sun saba da abin da ake kira nosocomial yanayi. Da yaki da su ne mai matukar wuya aiki, saboda da yawa kwayoyi su kawai ba aiki. Kwayoyin "linezolid" yana nufin ga waɗanda kwayoyi tare da wanda za a iya aikatã game da abin da ake kira nosocomial cututtuka ko wasu resistant zuwa wasu daban na kwayoyi. Shi ke nan game da shi da kuma za a tattauna a wannan labarin.

description

Drug "Linezolid" umarnin shafi antimicrobial m-bakan. A cewar ta asali dũkiyarsu da kuma halaye shi nasa ne da aji oxazolidinone cewa da ƙarfi, kuma da kewayon mataki da kwayoyin a mutunta mutane da yawa m ga miyagun ƙwayoyi "Vancomycin" da kuma sauran kayayyakin da a irin wannan abun da ke ciki.

Yau, akwai da dama iri antimicrobial wakili "linezolid". Samfurin tsari, an fi sau da yawa amfani a far, - wani membrane harsashi Allunan dauke da 400 ko 600 MG na aiki abu. Bugu da kari, a cikin likita yi jiko bayani ne sau da yawa amfani, wanda a kowane milliliter ƙunshi 2 MG na aiki abu da kuma foda (granules) shirya wani dakatarwar, da maida hankali na aiki sashi wanda shi ne 100 MG da 5 ml na karshe samfurin.

alamomi

Kamar yadda aka ambata a baya a wannan labarin, da miyagun ƙwayoyi "Linezolid" umurci manual shawara cewa kayi amfani da gaban cututtuka da lalacewa ta hanyar kwayoyin cuta resistant zuwa wasu maganin rigakafi. Wadannan sun hada da duka biyu gram-tabbatacce kuma gram-korau kwayoyin na da anaerobic ko aerobic iri da cewa sun ci gaba da juriya (kwanciyar hankali) ya methicillin, gikopeptidnym mahadi, penicillin da sauran maganin rigakafi.

A jerin cututtuka ga wanda wani "linezolid" medicament umurci hada da:

• asibiti ko al'umma samu ciwon huhu.
• fata cututtuka.
• taushi nama kamuwa da cutar.
• Sauran cututtuka da lalacewa ta hanyar kwayoyin-resistant Enterococcus.

Kamar yadda mai mulkin, kafin yin amfani da wannan magani gudanar da bincike don gano da juriya da pathogens zuwa wasu kwayoyi. Idan babu wani da aka samu, magani ne da za'ayi tare da taimakon wasu antimicrobial kwayoyi.

contraindications

Babban kuma mafi muhimmanci contraindication da amfani da kwayoyin 'Linezolid' umarnin don amfani da nufin hypersensitivity zuwa gare shi. Haka kuma an ba da shawarar a yi amfani da miyagun ƙwayoyi domin lura da marasa lafiya da suke shan wasu kwayoyi daga kungiyar na Mao hanawa. Bugu da kari, shi ba da shawarar ga wannan wakili tare da tricyclic antidepressants da abubuwa m tada jini (epinephrine, dopamine, da kuma sauran triptan).

Shiri "linezolid" (Allunan, jiko bayani da slurry) an contraindicated a cututtuka irin su hawan jini, hyperthyroidism, ko seratoninovy carcinoid ciwo, feohromotsitoz. A gaban wadannan contraindications dole ne a gano kafin fara far amfani da miyagun ƙwayoyi.

Hanyar mataki na kwayoyi a cikin jiki

Action "Linezolid" miyagun ƙwayoyi saboda da ikon toshe translation aiwatar da sunadaran gina jikin halittu a cikin sel da kwayoyin. Saboda da yaduwa daga kwayoyin da aka tsaya kuma akwai su mutuwa. Resistance zuwa da miyagun ƙwayoyi a cikin mafi yawan kwayoyin cuta da aka samar sosai a hankali.

Bayan ingestion na da miyagun ƙwayoyi aiki sashi siffofin da metabolite hydroxyethyl glycine. A mataki na ta tarayya, tare da jini sunadaran cinma wata 31% yi. A dakin gwaje-gwaje nazarin gano cewa fili da ke shiga cikin duk tsokoki da kuma gabobin. Shi ma yana da ikon ratsa cikin mahaifa zuwa tayin da nono madara (wannan dukiya da miyagun ƙwayoyi aka nuna a cikin shawarwari na shan miyagun ƙwayoyi da ciki da kuma lactating mata).

A rabin-rai na aiki abu da kuma ta metabolite excreted ne 4.5-5 hours. Tukar tumbi ne via da urinary tsarin (50% a matsayin metabolite da kuma 35% m), da kuma ta hanyar narkewa kamar fili (ba kasa da 9%). Complete tukar tumbi ya auku a cikin 8-12 sa'o'i bayan samun medicament.

Yadda za a yi "Linezolid"

Masana sun nuna cewa, a mafi yawan lokuta da haƙuri ba zai iya da kansa yanke shawara a kan hanyar liyafar "Linezolid" miyagun ƙwayoyi. Note, Allunan, mafita da kuma emulsions wanda ba su dauke a matsayin raba shirye-shirye, da kuma matsayin wani nau'i na miyagun ƙwayoyi, dauke da a wannan lokaci da cikakken bayani. Kasa ne key maki game da sashi da tsawon far.

Medicine "Linezolid" umurci manual shawara ta amfani da wadannan makirci:

1. A bayani ga jiko aka gudanar intravenously sau 2 a rana. A guda kashi na 400-600 MG aiki abu. A tsawon lokaci da magani dogara da tsanani da cuta da kuma ta sarrafawa. Yawanci, mafi cututtuka na bukatar wani lokaci na akalla 10 da kuma wani fiye da kwanaki 14, da kuma kawai a cututtuka da enterococci, magani yana daga 2 zuwa 4 makonni.
2. Shiri "linezolid" (Allunan) da aka dauka a matsayin sau 2 a rana, a wani adadin na 400, ko 600 MG da liyafar. Ga marasa lafiya shekaru 5 zuwa shekaru 14, da sashi da aka lasafta bisa ga jiki nauyi da kuma ya 10 MG da 1 kg na jiki nauyi, sau 2 a rana. A kalla kashi da ingestion (p.o.) kada wuce 600 MG. A tsawon lokaci da far ne m da wannan sigogi wanda aka dauke a sama.
3. Granules, wanda aka sanya na wani emulsion, amfani da sama makirci. sashi lissafi a lokacin da shi wajibi ne don gudanar da wani bisa ga wannan tafarki.

Tun da miyagun ƙwayoyi "Linezolid" an sanya na musamman da sayen magani da kuma ake amfani da kawai a asibiti, wani yawan abin sama da wannan makaman da kuma bayyanar pronounced illa ana kusan shafe ta. Likitoci a sake dubawa da aka ambata lokuta wuce haddi jari a cikin jikin aiki miyagun ƙwayoyi abu da kuma ta metabolites saboda cuta na urinary gabobin da kuma hanta. A sakamakon irin wannan overdoses yawanci sosai da sauri cire, a matsayin haƙuri ne daukarsu a karkashin akai dubawa na kwararru.

miyagun ƙwayoyi interactions

Tun da daya daga cikin sashi siffofin da miyagun ƙwayoyi "linezolid" ne aka yi nufi ga igiyar jini gwamnati, yana da muhimmanci cewa da miyagun ƙwayoyi ne gaba daya jituwa tare da asali mafita amfani a lokacin jiyya (5% glucose bayani, 0.9% bayani daga sodium chloride kuma Ringer ta bayani).

Musamman hankali ya kamata a biya su da yanayin marasa lafiya, wanda a Bugu da kari to "Linezolid" kai adrenergic kwayoyi. Idan cikakken kin amincewa da karshen ne ba zai yiwu, likitoci bukatar a duba su sashi.

Medicine "Linezolid '(irin wannan a cikin abun da ke ciki kuma za a iya daidaita su da shi) shi ne cikakken jituwa tare da kwayoyi" Chlorpromazine "," Cotrimoxazole "" Diazepam "da" Phenytoin ". Idan haƙuri kafin aikace-aikace na kwayoyin dauki ce nufin wajibi ne domin ya raya tazara 3 days kafin magani "linezolid" shirye-shiryen.

tsõratar

Kamar yadda ƙarin shawarwari a kan yin amfani da maganin rigakafi "Linezolid" umurci manual ƙunshi bayanai da suka shafi cikin mata masu juna biyu da kuma mutane da data kasance comorbidities. Bugu da kari, shi nuna yiwuwar illa. Amma da farko abubuwan da farko.

Amma ga liyafar "Linezolid" miyagun ƙwayoyi da sake dubawa na likitoci magana game da musamman taka tsantsan a lokacin da gudanar da su ciki da kuma lactating mata. Wannan shi ne saboda cewa da sakamako daga cikin miyagun ƙwayoyi a tasowa tayin ko da jariri da aka arancinsu karatu. Kullum, magani ne tare da amfani da shi ne kawai bu mai kyau idan hadarin da tayin muhimmanci a kasa da ana tsammanin amfani ga mahaifiyarsa.

A tukuru na koda da hanta gazawar, kuma bukatar da hankali aikace-aikace na magani, saboda metabolites ake excreted yafi a wadannan gabbai, da kuma jari daga cikin wadannan abubuwa a cikin su iya haifar da tabarbarewar da mãsu haƙuri.

illa

Bisa ga sakamakon da na asibiti lura, ba a ke so halayen na daban-daban gabobin da kuma tsarin a liyafar kwayoyin "linezolid" mafi sau da yawa shafi na juyayi da kuma narkewa kamar tsarin. Game da 10% na marasa lafiya a lokacin jiyya da aka lura tashin zuciya da kuma ciwon kai. A kadan kasa damu game da zawo, juwa ko jiri, kuma candidiasis a cikin baka mucosa.

Bugu da kari, da masana nuna irin wannan maras so effects da miyagun ƙwayoyi a matsayin gefe neuropathy, seizures, gani hanawa (har zuwa ta total asarar), thrombocytopenia, serotonin ciwo, angioedema da anaphylactic buga. Saboda gaskiya cewa da miyagun ƙwayoyi da ake amfani da kawai a wani asibiti yanayi, sau da yawa tsanani sakamakon an kauce masa.

Jiyya bayyana a ke so halayen a kan wani ɓangare na symptomatic da tsarin. Kau da miyagun ƙwayoyi ne zai yiwu ne kawai idan mai tsanani daga gefen effects ne babban matsalar fiye da cutar daukarsu dauke da kwayoyin.

Drug analogues "Linezolid"

Masu karatu watakila da tambaya game da ko "Linezolid" analogues da miyagun ƙwayoyi a can. Hakika, da pharmaceutical kasuwar idan ba cika, da shi yana da 'yan kwayoyi da suke kama da wadannan antimicrobial abun da ke ciki. Wadannan kwayoyi da dangantaka Serb kwayoyin "Zeniks" Norwegian "zyvox" da kuma Isra'ila "Linezolid Teva". A abun da ke ciki na dukkan wadannan kwayoyi a matsayin babban aiki abu hada linezolid.

Akwai gagarumin bambanci tsakanin wajen da kuma shirye-shiryen "Linezolid" da aka jera a sama? A farashin da kwayoyi - shi ke da babban bambanci. Gaskiyar ita ce, da ciwon guda abun da ke ciki, wadannan kwayoyi aiki a kan jikin mutum a daidai wannan: fafitikar da wannan microorganisms, sa wannan illa ne guda contraindications. Ba yawa daban-daban sharuddan da hanyoyin magani da kuma sashi.

Matsayin mai mulkin, da mafi tsada shigo da analogues "Linezolid" kwayoyin amfani a yayin da cewa wannan musamman miyagun ƙwayoyi ne ba yanzu a drugstores. Wannan ya faru sau da yawa, saboda ta yin amfani da mai fadi da kewayon marasa lafiya ne kusan ba zai yiwu ba saboda takardar sayen magani magani da kuma overdo a kan shelves ba za a iya warware babu wani daga cikin kantin magani sarkar. Daga wannan karamin jam'iyyar Bookings kwayoyi da kuma, sabili da haka, da damar a wasu nufi zuwa sayar da dukan stock.

A kudin da miyagun ƙwayoyi

A medicaments na oxazolidinone kungiyar suna da wani babban kudin saboda da hadaddun multistep kira na dũkiyõyinsu a Pharmaceutical dakunan gwaje-gwaje. Mene ne "Linezolid" miyagun ƙwayoyi farashin? Allunan (abun ciki na babban aiki abu da 600 MG, fakitin 10 guda) a cikin kantin magani, sarƙoƙi ne a kalla 18 dubu. Matsakaicin darajar wannan sashi nau'i ne 20 dubu rubles da 10 Allunan. Dan kadan mai rahusa ne da miyagun ƙwayoyi a kashi na 400 MG. Its farashin ne game 17-18 dubu rubles for 10 Allunan.

Da mafita ga jiko "Linezolid" ba za ka iya saya kadan mai rahusa: fakitin 10 fakitoci na 100 ml za kudin 7.5-9 dubu rubles, 10 fakitoci na 300 ml kowane - a 15,3-16,2 dubu rubles.

Da shirye-shirye na wannan sunan, wanda suna da yawa mai rahusa, sau da yawa ka zama mai jabu da kuma, a mafi kyau, da wani sakamako a kan haƙuri ta jiki. Duk da haka, da bata lokaci, a far da cutar, wanda taimaka rabu da kwayoyin 'Linezolid' kanta ne mai hadarin gaske. Shi ya sa masana bayar da shawarar don samun magani kawai a Pharmacy tare da suna mai kyau.

Comments game da kwayoyin "Linezolid"

Daban-daban kafofin iya ba safai sami reviews game da kwayoyin wannan aji. Wannan ya shafi musamman ga bayanai game da m, marasa lafiya da aka bayyana. Wannan shi ne saboda gaskiyar cewa mafi yawan marasa lafiya a lokacin far ne a ƙwarai da gaske yanayin, da kuma tuna da dukan kayan rikewa-gaba da jin su ne musamman wuya.

Kwararru, bi da bi, ya amsa magani "Linezolid" musamman m. A cewar su, da miyagun ƙwayoyi ne iya jimre ma mafi resistant germs. Sun kuma nuna cewa, hadarin da rikitarwa saboda illa ko yawan abin sama shi ne kusan ƙarancin. Wannan shi ne saboda cewa an kwayoyin da ake amfani da kawai a asibiti saituna. A farko alamar rashin lafiyan ko m halayen da miyagun ƙwayoyi suna da za'ayi duk dole likita hanyoyin kawar da su.

Saboda haka, za mu dubi duk cikakkun bayanai daga cikin miyagun ƙwayoyi "linezolid". Umarnin don amfani, farashin kuma zai yiwu miyagun ƙwayoyi halayen da aka bayyana a cikin wannan takarda, daki-daki. Ya kamata a lura da cewa, duk da babban kudin da miyagun ƙwayoyi, ta yin amfani ne wajaba a kowane hali. Yanke shawara a kan lura da marasa lafiya wannan magani iya kawai likita.