Alt ya karu. Abin da ya yi?

alanine aminotransferase (Alt) enzyme dauke a cikin hanta amfani da matsayin nuna alama don gane cuta da ta ayyuka. Menene gaskiyar, idan Alt matakan ƙara?

Daga cikin enzymes masu yawa da suke da Manuniya na hepatocellular cuta, mafi amfani da dole ne alanine aminotransferase (Alt) da kuma aspartate aminotransferase (AST). Ta hanyar su kara canja wurin dauki a wani gamma-gamma band ketoglutarate alanine da aspartate kungiyoyin. A sakamakon wannan tsari samar pyruvic da oxaloacetic acid.

Kuma Alt da AST - salula enzymes koda, hanta, zuciya. Duk da haka, alanine aminotransferase, yafi located in hanta da kuma shi ne mafi asali na ta nuna alama, da kuma aspartate aminotransferase -. Kamar yadda wani ɓangare na da yawa (wanin wadanda aka jera a sama) da gabobin da kyallen takarda, ciki har da kwarangwal tsoka, kwakwalwa, da dai sauransu Wannan shi ne dalilin da ya sa key enzyme AST ne ƙasa da na kowa a matsayin nuna alama na hanta aiki, kuma yana daukan bangare a amino acid metabolism.

Idan akwai halakar hanta Kwayoyin, zuciya, koda, alanine aminotransferase (Alt) a cikin jini faduwa. Karuwa daga cikin salon salula enzyme a cikin jini abun da ke ciki na nuna latent cututtuka. Lokacin da nazarin ya nuna cewa babban Alt matakan, na iya samar da quite tsanani cututtuka a cikin jini, kamar:

- cirrhosis,

- kwayar hepatitis,

- myocarditis,

- hanta ciwon daji,

- zuciya rashin cin nasara,

- wani ciwon zuciya.

Kuma da karuwa aspartate aminotransferase a cikin jini iya kai wa ga

- ciwon zuciya,

- hanta ciwon daji,

- murdede dystrophy ,

- pancreatitis,

- paroxysmal myoglobinuria,

- hepatitis,

- dermatomyositis,

- zuciya rashin cin nasara.

Idan, duk da haka, sauran kudi na AST da Alt ya karu, akwai iya zama:

- m hanta necrosis,

- toksinogennye hanta lahani,

- tsanani kwayar hepatitis,

- dogon-jijiyoyin bugun gini auka.

Kusan dukkan cututtuka na mutum jini nazarin ya nuna cewa kudi da kuma AST, kuma Alt ya karu, wato, da matakin na biyu enzymes a wadannan lokuta ne kusan guda da kuma nuna gaban Pathology. Amma akwai yet wani bambanci. Idan Alt matakan ƙara zuwa mafi girma har fiye da aspartate aminotransferase, wanda yake nuna shiryawa zamani na hepatitis B kamuwa da cuta. Idan jini ACAT more, shi mafi sau da yawa tare da zuciya matsaloli.

A wani m mutum da abinda ke ciki na wadannan salon salula enzymes ya zama a matakin:

- a maza har zuwa 41 raka'a da lita (U / L).

- a mata har zuwa 31 raka'a da lita (U / L).

Don gane da matakin na wadannan enzymes, da furotin da metabolism, kai jini sunadarai. Kullum domin Alt cikinta 28-190 nmol / (c l) ko 0.1, 68 mmol / (ml hr) da kuma ga ACAT - 28-25 nmol / (c l) ko 0,1-, 45 pmol / (ml hr). Wannan mulki ne a lokuta biyu ne da aka ba ga Hanyar Reitman-Frankel (colorimetric Hanyar bincike).

Yawancin lokaci, jini gwaje-gwaje alanine aminotransferase gudanar da su koyi game da jihar na hanta, da kuma aspartate aminotransferase - a ga jihar na myocardium (zuciya tsoka). Idan bincike ya nuna su high jini, yana nufin cewa tafiyar matakai na halaka da kuma cell mutuwa faruwa a wadannan gabbai. Saboda haka, idan AST wuce ta matakin a cikin jini a cikin 2-20 sau, to, shi ne zai yiwu a ci gaba da tsokar zuciya infarction. Idan Alt matakan ƙara, akwai wani pathological tsari a cikin hanta.

Karkashin rage nuna alama na jini alanine aminotransferase da aspartate aminotransferase masana san cewa jiki ta rashin pyridoxine (bitamin B6). Yawanci wannan ya faru a lokacin daukar ciki, tare da m hemodialysis da na koda gazawar.

Abin baƙin ciki, daga jini magani na da lafiya mutum ne wadannan enzymes ne ba a sani ba, don haka da unintelligible da su inji na yarda (kudi na gudun da jini magani, wasu bioliquid da kyallen takarda da wani abubuwa saboda su redistribution, biotransformation, kawar daga jiki).