Exchange of bilirubin
Hanyoyin motsin jiki na jini yana samar da kayan jikin mutum tare da adadin yawan oxygen, wanda ke dauke da wani mai karfin gaske-haemoglobin-a cikin tsarin jini. Duk da haka, waɗannan kwayoyin suna da ƙayyadaddun rai, kimanin kwanaki 100-120. Sa'an nan kuma su shiga cikin ɓarna na jini, inda aka saki haemoglobin daga gare su. An haɗu da shi a halin yanzu ta hanyar haɓoglobin kuma an kai shi zuwa cikin sel na tsarin reticuloendothelial don ƙarin cigaba zuwa aladun da ba mai guba (bilirubin direct) da excretion tare da bile. A macrophages da histiocytes, hawan hemoglobin da farko ya ƙaura zuwa biliverdin, wanda yake shi ne alamar pyrrole 4 da aka daure ta gado na methane. Sa'an nan kuma an mayar da ita zuwa bilirubin na yau da kullum, wanda kamun-furotin ya kama shi kuma ya koma cikin hanta. A cikin parenchyma, canjin sa zuwa bilirubin ya kai tsaye, wato, ɗaukar glucuronate don warwarewa.
Matsayin kwayoyin
Matsayi mai banƙyama a cikin ƙarin halayen da za a saki sinadarai bile yana aiki ne ta hanyar microflora na intestinal al'ada. Bilirubin ke faruwa a mike daga hanta a cikin abun da ke ciki na bile a vesica fellea, da kuma lokacin da bude faterova kan nono shiga duodenum, da kuma kara, a cikin kananan hanji, inda warware daga glucuronic acid da kuma tuba a cikin sterkobilinogena outputting da faeces. Wani ɓangare na shi lokacin wucewa ta hanyar dubun dubura yana tunawa da ciwon kwadar jini wanda ya shiga cikin jini, ta hanyar hawan hanta, kuma an cire shi ta hanyar kodan da fitsari. Saboda haka, a cikin jinin, bilirubin kyauta da kai tsaye ana gano su kullum. Halin na karshen shine kimanin 5.1 μmol / l, da kuma jimlar - 15.
Sanin asalin cututtukan hanta
Ta hanyar haɓaka da rabo daga waɗannan alamun, mutum zai iya yin hukunci akan aikin hanta. Saboda haka, idan parenchyma na wannan kwayar yana da lalacewa mai guba ko mai guba, yawancin alamar kyauta ba zata kasance ba, kuma maida hankali cikin jini na nau'i biyu na pigment yana ƙaruwa sosai. Bilirubin an gano shi a cikin jini a cikin abin da ake kira jaundice mai magani, wanda akwai matsaloli ga kwarara irin na bile, kuma a dangane da wannan akwai tsarin regulagitation na bile cikin jigilar jini. Dalilin wannan yana iya zama damuwa da ƙwayar bile tare da tumɓin jini mai ƙananan jini, zubar da dutse, da dai sauransu. Akwai jaundice mai ban mamaki, wanda dalilin da ya faru shi ne ƙaddamar da haɓakar haemoglobin a jini. Hakanan zai iya rinjayar ciwon halayen kwayoyin halittu da kwayoyin halitta, wasu yanayin ilimin lissafi. Duk da haka, saboda dukkanin wadannan hepatitis, bilirubin yana tarawa cikin kyallen takarda. Sakakken guda saboda ta lipophilicity, shi sauƙi ratsa cikin Kwayoyin, ciki har da ta hanyar da jini-kwakwalwa shãmaki, kuma rarrabe electron kai sarkar a cikin mitochondria, game da shi inhibiting makamashi metabolism. Mafi aminci a cikin wannan batun bilirubin ne madaidaiciya, wanda al'ada ba shine mai guba ba, tun da kwayoyinsa ba su da tushe.