Bullous pemphigoid: cututtuka, magani, da kuma hotuna

Bullous pemphigoid - a gwada kowa fata cuta da yayi kama da na waje manifestations pemphigus. Haka kuma cutar na faruwa a kullum tsari da kuma a cikin rashi na m bincike da kuma magance iya kai wa ga m sakamakon. Saboda haka abin da ya haddasa ci gaban da wannan cuta? Mene ne bayyanar cututtuka da shi bayyana kanta? Mene ne wajen domin magani na zamani magani ya bayar? Amsoshin wadannan tambayoyi ne suke da muhimmanci ga masu karatu da dama.

Abin da yake akwai wata cuta?

Bullous pemphigoid a zamani magani da aka sani da yawa sunayen - cewa Lever ta cuta, da kuma na tsufa pemphigus, dermatitis herpetiformis da kuma na tsufa. Yana da wani kullum autoimmune cuta, wadda yana tare da bayyanar da fata rash na bororo manyan (external bayyanar cututtuka wani lokacin kama gaskiya pemphigus).

Shi ne ya kamata a lura da cewa mafi yawan marasa lafiya tare da wannan ganewar asali - shi ne mutane shekaru 65 shekaru da mazan. Da sauƙi, magani da aka sani ban, kamar yadda cutar da ake wani lokacin samu a yara da kuma tsakiyar-shekaru marasa lafiya. The rashin lafiya ne halin da mai kirki ba shakka, amma shi iya, wani lokacin kai ga rikitarwa. The asibiti hoto na zumunta ci gaba alternated da lokaci na exacerbation. Hakika, ga mutane da yawa, da tambaya ban sha'awa shi ne gaskiya cewa shi ne mai bullous pemphigoid. Alamun da kuma lura da cutar, ta haddasawa - wannan bayani ya karanta more a hankali.

Wasu irin wannan cuta

Shi ne ya kamata a lura da cewa bullous pemphigoid ne wani ɓangare na ƙungiyar da ake kira cystic dermatosis. Wadannan cututtuka suna bambanta daga gaskiya pemphigus, tun da shi ne ba tare da acantholysis. fata raunuka kungiyar hada da dama cututtuka, da na asibiti hoto wanda quite kama da:

• Yãfẽwa pemphigus neakantoliticheskaya a wadda cuta rinjayar na musamman na baka mucosa ba tare da haddasa rashes a kan wasu shafukan. Cutar da ake kuma halin da benign hanya. Af, shi aka farko aka bayyana a cikin shekarar 1959.
• Scarring pemphigoid - quite wani hatsari cutar da ke shafar da mucous membrane na ido da kuma conjunctiva, suna ɓuɓɓugar da shi atrophy. Rashes a jiki ne zai yiwu, amma faruwa gwada infrequently. Babban hadarin kungiyar - mata 50 shekara, ko da yake wani lokacin da cutar da aka rubuta a cikin maza marasa lafiya.

A Sanadin kuma pathogenesis na bullous pemphigoid

Abin baƙin ciki, da tsarin ba da abin da ya faru da wannan cuta ne har yanzu ba cikakken gane. Duk da haka, masana kimiyya sun iya tabbatar da cewa cutar ne autoimmune a yanayi. Ga daya dalili ko wata akwai kasawa a cikin aikin na rigakafi da tsarin, sakamakon da samar antibodies suna kai hare hare ba kawai kasashen waje, amma kuma jiki ta mallaka Kwayoyin.

Evidence wannan ka'idar ne akwai. A lokacin da magani daga mãsu haƙuri bincike, kazalika da a cikin ruwa dauka daga kumfa, musamman antibodies an same su lalata muhimmi membrane na fata tsokoki da kuma mucous membranes. Har ila yau, an gano cewa mafi aiki da cutar tasowa, da hakan da titer daga wadannan antibodies.

An yi imani da cewa autoimmune cututtuka suna lalacewa ta hanyar halittar jini. Duk da haka kana son ka factor da za su iya kunna cutar. Wannan na iya zama:

• Alurar riga kafi da wasu cututtuka.
• lalacewa ko tsanani fata hangula.
• daukan hotuna zuwa ultraviolet radiation (dogon sunbathing, solarium zagi, da dai sauransu ...).
• Thermal konewa da fata.
• m amfani da wasu magunguna, kamar "Furosemide", "captopril", "phenacetin", "amoxicillin" da kuma wasu sauran.
• Wani lokaci da cutar da aka kunna bayan da nassi na haƙuri radiation far.
• koda dashi kin amincewa, sashin jiki dasawa maimaita.

Bullous pemphigoid: photo da cututtuka

Hakika, na farko na duk yana da muhimmanci ka san ko kanka tare da bayyanar cututtuka, saboda jima da haƙuri zai kula da wanzuwar take hakki da kanemi shawara, da sauki da magani aiwatar faru. Ilimi a kan fata m vesicular eruptions - babban alama na wanda yana tare da bullous pemphigoid (Photo nuna look daga cikin rash). Mafi sau da yawa rinjayar da fata na wata gabar jiki da kuma akwati. Rash iya faruwa a cikin filin daga manyan halitta creases a kan fuska da kuma fatar kan mutum, amma da ta faru da wuya.

Babban abubuwa na shigowa - vesicles da blisters tare da wani ƙunci tayoyin. A ciki suka samu wani ruwa, yawanci m, amma wani lokacin za ka iya lura jini. Sau da yawa, fata a kusa da ja kumfa.

A lokaci na "rayuwa" na tsarin na 'yan kwanaki. Bayan haka, da suka spontaneously bude. A site na raunuka kafa yashewa yankunan da kananan ulcers. Ɓawon burodi a kan surface ba kafa a matsayin erosive yankunan da sauri epiteliziruyutsya.

A farko, saukarwa da cutar a 20% na marasa lafiya a fara da bayyanar kumfa a kan baka mucosa, sa'an nan ya shiga cikin fata da garaje. Blisters a kan mucous membranes na hanci, makogwaro, al'aurar, idanu bayyana sosai da wuya.

Marasa lafiya koka itching, da kuma bayan bude kumfa da kuma wasu soreness. Zai yiwu karuwa a yawan zafin jiki, ko da yake wannan ne rare. A tsofaffi da marasa lafiya, da jiki da cewa an tsautsayi da m dakwai, komowan cutar, aka kuma lura da rage a ci, nauyi asara, m rauni.

Histogenesis, histopathology da patomorfologija

Pathology bullous pemphigoid ne quite ban sha'awa. Da farko cytoplasmic matakai tsakanin muhimmi Kwayoyin kafa yawa vacuoles. A hankali wadannan tsarin ana garwaya tare da nunawa fi girma Tsarin. Tare da wannan, akwai mai kaifi da kuma edema na dermis kyallen takarda.

Taya mafitsara - shi ne epidermal nama. Sel ta miƙa, amma gadoji tsakanin su ba lalace. Kamar yadda cutar ne a hankali a hankali withering bãya daga cikin epidermal Kwayoyin. A lokaci guda, sabon epidermal nama suna gabatowa, tare da kumfa gefuna, kama ta kasa - haka vesicles motsa baxini na epidermis kuma wani lokacin a podrogovoy Layer.

Ciki kumfa akwai wani ruwa da ya ƙunshi lymphocytes da wani admixture na neutrophils. Akwai strands na fibrin, da sunadarai na gina jiki da kuma wasu sauran mahadi.

Idan muka yi la'akari da histogenesis na bullous pemphigoid, da farko yana da daraja ambaton cewa cutar ne autoimmune. A cikin nazarin kyallen takarda ta na'urar hange za a iya lura da cewa, abin da ake kira antigens BPAg1, wanda aka saki a lokacin da wani rigakafi martani suna located in muhimmi Layer, wato a kayyade poludesmosom keratinocytes. Wani antigen - BPAg2 - ma dake a yankin poludesmosom. An yi imani da cewa shi ne kafa ta collagen irin XII.

Har ila yau a lokacin gudanar da bincike an gano cewa, macrophages da eosinophils a wannan cuta da farko tara a cikin muhimmi membrane, sa'an nan hijira ta hanyar da shi da kuma za a fara tara a cikin mafitsara da kuma tsakanin muhimmi Kwayoyin. Har ila yau, akwai wani gagarumin degranulation na mast Kwayoyin.

Histologically, cutar da ake gani a lokacin da exfoliation na epidermis daga dermis, da kuma tsakanin wanda aka kafa subepidermal bororo. Tasoshin a cikin fata tsokoki kuma kumbura, can an busa na ciki yadudduka (endothelium).

Hanyoyin zamani na ganewar asali

Kamar yadda mai mulkin, babu matsaloli tare da ganewar asali na irin wannan cututtuka kamar bullous pemphigoid: bayyanar cututtuka su ne sosai musamman, sabili da haka your likita yi zargin cutar riga a lokacin da misali dubawa. A haƙuri da fata m kumfa an kafa, da kuma aiwatar da epithelialization na erosions auku hanzari.

Kwasfa gwajin korau epidermis. Bugu da kari, da shinge ne da za'ayi na ciki abinda ke ciki na kumfa tare da kara histological jarrabawa. A lokacin dakin gwaje-gwaje gwaje-gwaje za a iya samu a cikin ruwa vacuoles histiocytic abubuwa, eosinophils da lymphocytes.

A daya hannun, da bambanci da ganewar asali ne wani lokacin fraught da matsaloli, kamar yadda na asibiti hoto ne dan kadan reminiscent na sauran fata cututtuka, ciki har da multiforme exudative erythema, gaskiya da kuma pemphigus herpetiformis dermatitis Duhring.

Abin da magani aka dauke su tasiri?

Abin da idan ka samu bullous pemphigoid? Jiyya a cikin wannan hali na bukatar wani hadadden. Bugu da ƙari, zabin da wasanni ayyukan da magani dogara a kan al'amurra da dama, ciki har da mai tsanani da cuta, da shekaru da kuma janar kiwon lafiya na haƙuri, gaban comorbidities. A cikin wani hali, da magani regimen iya sanya kawai da halartar likita.

Dalili na far - steroid anti-kumburi kwayoyi dauke da steroids. Mafi sau da yawa amfani da wannan manufa "Prednisolone". Da miyagun ƙwayoyi ne gudanar intravenously da sashi ne a hankali rage matsayin bacewar bayyanar cututtuka.

Har ila yau, mai kyau da sakamako ne da aka ba cytostatics da immunosuppressive jamiái cewa taimaka wa normalize aiki na rigakafi da tsarin. Popular sau da yawa, marasa lafiya wajabta kwayoyi kamar "Cyclosporin A", "Cyclophosphamide", "Azathioprine".

Hakika, lamari ne mai muhimmanci da magani daga raunuka, erosions da ulcers a kan fata. Wajibi ne a ci gaba da fata mai tsabta. Marasa lafiya gudanar mafita da aniline dyes (msl, "Furkotsin") wanda aiki a matsayin magunguna iri iri ko bushewa fitar da fata. A mafi tsanani lokuta ma bukatar man shafawa da steroids.

Jiyya tare da jama'a magunguna

Bullous pemphigoid, ko Lever cuta - a Pathology cewa bukatar wani m, m magani. A amfani da daban-daban magunguna na gida zai yiwu, amma kawai tare da izni na gwani. Kafin ka iya amfani da kowace manufa, ya kamata ka yi shãwara da your likita. A jama'a magani amfani da dama daban-daban kwayoyi.

• An yi imani da cewa wani m jihar kiwon lafiya na haƙuri shafi cikin tincture na Eleutherococcus. Kai shi ya zama sau biyu a rana, 30 saukad.
• Domin waje amfani rash aiki ruwan 'ya'yan itace daga ganyen Aloe, wanda taimaka wa taimaka itching da kuma soreness, ya hana ci gaban kumburi, accelerates farfadowa. The ruwan 'ya'yan itace ka bukatar ka moisten da bandeji, sa'an nan kuma amfani da shi zuwa shafa fata yankin da kuma kafa bandeji. Domin matsakaicin sakamako, za ka iya rufe kunsa da filastik kunsa.
• Tare da wannan manufa, mai sabo ne ruwan 'ya'yan itace, ko wani decoction na nettle ganye za a iya amfani da su. Poultice sanya na sama-aka bayyana makirci.
• Bullous pemphigoid, ko fiye daidai, ta bayyanar cututtuka za a iya alleviated tare da wani musamman na ganye decoction. Don yin shi ya dauki wani daidai adadin (50 g) na eucalyptus ganye, rhizomes nada 'ya'yan Sophora japonica, Birch buds, Yarrow, makiyayi da jaka da nettles. Biyu tablespoons na tattalin cakuda da yamma ganye, zuba gilashin ruwan zãfi, da barin dare. A safiyar jiko wajibi ne don lambatu da kuma raba cikin uku rabo - dauki su a lokacin da rana.

An fahimci cewa na ganye magunguna domin kowane haƙuri iya aiki daban. Ko da wakili yana da kyau sakamako, a wani hali ba daina shan magani.

A hangen nesa ga marasa lafiya

Pemphigoid - a benign cuta na fata, sabili da haka faruwa a mafi yawan lokuta ba ma wuya. Haka kuma, kusan duk wani babban birni asibiti ya yi nasara jiyya ga cutar ne saboda haka rikitarwa sunan - bullous pemphigoid. A Orenburg, Moscow, da kuma wani birni, ka tabbata ga samun mai kyau gwani. Wurin zama zai dogara ne a kan fãce da kudin magani, tun lokacin da farashin wasu magunguna a daban-daban kantin abubuwa bambanta.

Lokacin da ya kamata gudanar da magani iya cimma wani barga gafarta musu. Daga lokaci zuwa lokaci akwai wasu marasa lafiya da komowa, wanda, ba shakka, m, amma ba m. A daya hannun, a lokacin da babu wani magani wurin samuwar raunuka iya zama ƙofa ga kamuwa da cuta, bi da bi kammala mafi m kumburi, suppuration da raunuka, infiltration na pathogenic kwayoyin cuta a cikin zurfi fata yadudduka.

Ashe, akwai wani wajen rigakafin?

Abin baƙin ciki, akwai wani takamaiman wajen domin hana irin wannan cututtuka kamar bullous pemphigoid Lever. Halitta, yana da muhimmanci a nemi taimako a lokacin, da kuma yadda wani kullum cutar, har ma a lokaci na zumunta alheri bukatar a hankali saka idanu da jihar na kiwon lafiya.

Kada ka manta cewa da cuta a cikin magani ne a matsayin wani m ciwon daji alama. Wannan shi ne dalilin da ya sa gaban cutar da mãsu haƙuri dole ne sha wani m jarrabawa don tabbatar da ko sarauta daga ganewar asali Cancer. Ka tuna cewa da wani ciwo ne sauƙin jimre idan ka fara jiyya da wuri.