Da miyagun ƙwayoyi "Ursodez" - umarnin don amfani. Allunan "Ursodez": analogs da kuma sake dubawa

Drug "Ursodez" - hepatoprotective miyagun ƙwayoyi. Yana yana da choleretic medicament, hypolipidemic, holeliticheskoe mataki, ya mallaka hypocholesterolemic da immunomodulating sakamako negligible. Active abu - ursodeoxycholic acid. Da miyagun ƙwayoyi yana da wani sashi form "kwayoyi". "Ursodez" da aka samar a cikin nau'i na capsules.

aiki inji

The aiki miyagun ƙwayoyi abu yana da ikon da za a kafa a cikin membrane na hepatocytes, tabbatar da dorewar da tsarin. A sakamakon haka, da Kwayoyin suna kare daga damuwa dalilai, da ayyukan da bile acid salts. A warkewa sakamako daga cikin miyagun ƙwayoyi bayyana haka ragewan a cytotoxic sakamako. Kan bango na cholestasis activates Ca2 + dogara protease alpha-kara kuzari exocytosis. Na nufin "Ursodez" (User aikace-aikace nuna shi) ƙwarai rage mai guba bile acid (deoxycholic, lithocholic, chenodeoxycholic da sauransu) a dagagge yawa a cikin marasa lafiya da na hanta pathologies a kullum hanya.

Lokacin da samun magani alama karu a cholesterol kira da mugunya, hanawa na ta sha a cikin hanji. Saboda wannan, shi rage-rage jikewa na bile tare da wannan fili. A shirye-shiryen da ikon yin gasa rage absorbability na lipophilic acid a cikin hanji, kara da fractional yawa ƙasa enterohepatic wurare dabam dabam. Magani stimulates tukar tumbi da mai guba acid, ya karu nassi.

Ginshikai na mataki na miyagun ƙwayoyi kuma bisa nunawa nonpolar bile acid. Saboda wannan mai guba gauraye micelles. Yana nufin intensifies a biliary tsarin, da solubility na cholesterol, dattako samar da mugunya bile. A miyagun ƙwayoyi kuma rage lithogenicity, qara taro na acid, ta haka ne ya sa wani karuwa a aiki na pancreatic da kuma na ciki da mugunya.

Lokacin karbar capsules da cikakken ko m rushe duwatsu. By rage bile cholesterol jikewa inganta janyo ra'ayoyin jama'a da duwatsu. Immunomodulatory aiki ne nuna saboda da tasiri a kan Game da dauki da hanta. Da miyagun ƙwayoyi rage magana da wani yawan histocompatibility antigens. A medicament yana da wani sakamako a kan matakin da T-lymphocytes, rage yawan eosinophils.

Pharmacokinetics nufin

Absorption da miyagun ƙwayoyi "Ursodez" (umurci manual nuna wannan) a cikin kananan hanji yi da wani tsari na m yadawa. Cirewa tare da game da 90% na aiki bangaren. A ileum da abu da ake tunawa da aiki kai. A mafi abun ciki na aiki bangaren kai kimanin sa'a daya. A fili yana da wani babban kashi na dauri gina jiki - 99%. Ursodeoxycholic acid ne iya shiga cikin mahaifa.

A warkewa inganci daga cikin miyagun ƙwayoyi dogara da taro na aiki sashi a cikin bile. A yau din samun wannan bile acid zama na farko magani. ursodeoxycholic acid maida hankali ne game da 48%.

A fili ake metabolized, shi ya wuce ta hanta Kwayoyin. A sakamakon haka, kafa glycine da taurine conjugates. A lalata kayayyakin an secreted cikin bile. Game 50-70% samu da miyagun ƙwayoyi ne excreted a cikin tumbi. A kananan adadin da miyagun ƙwayoyi ne hawa cikin ciwon. Akwai shi ne raba ta da mataki na kwayoyin cuta (7-dehydroxylation).

Lithocholic acid, wanda aka kafa ta wannan tsari, an hõre wani m sha na manyan hanji, amma ya wuce sulfation a cikin hanta da kuma excreted kamar yadda sulfolitoholiltaurinovogo ko sulfolitoholilglitsinovogo conjugate.

shaidar

Medicine "Ursodez" shawarar a matsayin symptomatic far ga primary biliary cirrhosis ba tare da ãyõyi decompensation. Nuna wajen soke da matsakaici da kuma kananan cholesterol duwatsu, tare da aiki gallbladder. Prescribers da biliary reflux gastritis.

contraindications

Na nufin "Ursodez" wa'azi a kan aikace-aikacen ba da damar zuwa ga makõma idan haƙuri rentgenpolozhitelnyh (da babban taro na Ca2 +) gallstones rashin ha} uri medicament aka gyara. Contraindications hada cirrhosis a mataki decompensation bayyana cuta na pancreas, koda. Shawarar miyagun ƙwayoyi domin mutane da wadanda ba aiki gall mafitsara, m kumburi pathologies na da yanayi, kazalika da hanji cuta da bile bututu. Kada rubũta magani don ciki da kuma reno. Yana nufin contraindicated ga manya da yara yin la'akari kasa da 34 kg.

illa

A wasu lokuta, ci gaba maras so effects yayin da shan miyagun ƙwayoyi, "Ursodez". Umurnai na amfani gargaɗi kan yiwuwar tashin zuciya, zawo da amai. A cikin ƙasa magani iya samar da calcified gallstones. Karawa hanta transaminase aiki, ciki zafi, rashin lafiyan halayen (ciki har da urticaria) ne ma a ke so sakamakon ingestion "Ursodez".

Shedu nuna kyau tolerability. Subject ga likita ta prescriptions illa ne da kamar wuya. A wasu lokuta, a lokacin jiyya na biliary cirrhosis lura dõgẽwa decompensation. Matsayin mai mulkin, wannan sabon abu kadai ta ci gaba bayan an daina miyagun ƙwayoyi.

Drug "Ursodez". Price. umurci

Yana nufin shan da yamma. A kullum sashi don rushe duwatsu - wani talakawan of 10 MG / kg. Domin mutane yin la'akari har zuwa 60 kg shi yayi dace 2nd capsules da rana zuwa 81 kg- 3-m, 100 kg - 4 more 100 - 5. Duration - daga watanni shida zuwa 12 watanni. Bayan dissolving da duwatsu domin hana samuwar sabuwar shawarar ci ga wani watanni da dama.

Jiyya biliary cirrhosis da za'ayi a wani kashi na 250 MG / rana. Duration daga cikin shakka - 10-14 kwanaki. har zuwa watanni shida. A wasu lokuta, tsowon lokacin far ne ta ƙara zuwa shekaru biyu. Kamar yadda wani symptomatic magani medicament gudanar 10-15 MG / rana. Lokacin da taro don 34 kg Nagari nufin dakatar da form. A kudin da miyagun ƙwayoyi a kwantena tsari - daga ɗari da rubles.

Yana aikata shi yana nufin "Ursodez" takwarorinsu?

Kwayoyi dake dauke da wannan aiki abu, samar da sallama mai yawa. Daga cikin su shi ne daraja ambata wannan hanyar a matsayin "Ursodoksa", "Ursol". Daya daga cikin mafi mashahuri ne da miyagun ƙwayoyi "Ursosan". Alamomi ga yin amfani da miyagun ƙwayoyi ne da ɗan fadi. A musamman, shi ne gudanar a cystic fibrosis hanta skleroziluyuschem cholangitis kullum irin.

Mutane da yawa marasa lafiya suke sha'awar abin da mafi alhẽri shirye-shiryen "Ursodez" ko "Ursosan". Ya kamata a ce cewa likita ance daya ko wasu wajen daidai da yanayi, ba shakka na Pathology da haƙuri jure da miyagun ƙwayoyi. A cututtuka na hanta, da gallbladder ba sosai shawarar kai. Kafin shan wani magani da ka bukata jarrabawa da shawara tare da wani gwani.

Sa idanu da tasiri na magani ya kamata a da za'ayi a kowace 6 watanni. A wannan dangane da shi da ake sa na yau da kullum duban dan tayi da X-ray jarrabawa a farkon shekara da magani. Idan a cikin watanni shida na farkon da rushe duwatsu bai faru ba, shi ne wata ila ci gaba da hanya impractical saboda gazawar.

ƙarin bayanai

Don a tabbatar da nasara rushe duwatsu shi ne cewa wajibi ne da duwatsu sun kawai cholesterol, amma su size bai wuce 15 ko 20 millimeters. A daidai wannan lokaci cike da gall mafitsara ya kamata ba fiye da rabin, da kuma biliary fili kamata ta riƙe da aiki gaba daya.

A cikin hali na tashar tsawo magani, fiye da wata daya, ya zama dole a gudanar da wani biochemical kima for kimantawa aiki na transaminases a cikin hanta. Bugu da ƙari kuma, shi ya kamata sarrafa taro na bilirubin da sauran mahadi. daina shan "Ursodez" wajen yayin da rike high yi. Reviews na kwararru da yawa, duk da haka, ne tabbatacce game da tasiri na da miyagun ƙwayoyi.

ƙarshe

Idan babu sakamakon za a iya sanya wani medicament ko magani dabarun gaba daya bita. Kafin amfani da samfurin ya zama saba da annotation.