"Endoxane": umarnin don amfani, real takwarorinsu, da manufacturer

Drug "endoxane" tana nufin wani rukuni na anti-ƙari jamiái. Dangane da tsari na saki da shi za a iya gudanar da baki ko parenterally. Abin da irin miyagun ƙwayoyi sanya da kuma a cikin abin da sashi, solves kawai likita a kan tushen da ainihin hali na haƙuri da yanayin.

A abun da ke ciki da kuma kaddarorin da miyagun ƙwayoyi

Babban aiki sashi daga cikin miyagun ƙwayoyi "endoxane" umarnin don amfani da nufin cyclophosphamide. Daya kwamfutar hannu ya ƙunshi 50 MG na shi. A magani tana nufin wani rukuni na antitumor kwayoyi da kuma shi ne mai biconcave Allunan tare da wani farin ambulan da kuma ainihin wannan ya dafa. Kamar yadda ƙarin aka gyara aiki pharmaceutical samfurin hada da alli carbonate da hydrogen phosphate, sodium karamellozu, glycerol, gelatin, lactose, masara sitaci, macrogol, magnesium stearate, polysorbate, sucrose, talc, silica da titanium.

Mene ne pharmacology da miyagun ƙwayoyi?

Babban aiki miyagun ƙwayoyi abu, wato cyclophosphamide, alkylating kuma yana da cytostatic sakamako. By da yanayi, shi ne kusa da mustard gas, nitrogen kasancewa ta analogue.

Ginshikai na mataki na cyclophosphamide dangane da samuwar crosslinks tsakanin DNA din da RNA da kuma gina jiki kira suppressing jikinsu.

A pharmacokinetics da miyagun ƙwayoyi

Babban aiki sashi "endoxane" da miyagun ƙwayoyi yana da kusan cikakkiyar mataki na absorbability daga cikin gastrointestinal fili. Its taro a jini bayan baka da kuma igiyar jini gwamnati ne guda. Cyclophosphamide metabolism faruwa musamman a cikin hanta, inda a ƙarƙashin rinjayar microsomal oxidase inji shi ne samuwar aiki alkylating metabolites. Wasu daga cikin su suna tuba a cikin m siffofin, wani rukunin da aka yi ƙaura zuwa Kwayoyin, inda enzymatic mataki na phosphatases canza kama zuwa abubuwa da cytotoxic Properties.

A mataki na dauri na asali nau'i na da miyagun ƙwayoyi da jini da sunadarai ne negligible kuma shi ne 12-14%. Duk da haka, wannan nuna alama na metabolites riga daidai 60%.

cyclophosphamide samar da koda tukar tumbi da mafi yawa a cikin nau'i na metabolites. Aƙalla 5-25% daga cikin miyagun ƙwayoyi ne excreted a asalin siffan a cikin fitsari da kuma bile.

Siga T1 / 2 a kwayoyi daidai 7 hours ga manya da 4 hours yara.

A abin kashi dauki da magani?

Drug "endoxane" a kwamfutar hannu tsari dauka baki da abinci ko rabin awa bayan cin abinci, bayan 2 hours.

Saboda gaskiya cewa pharmaceutical samfurin kunshe a cikin manyan yawan tsoka regimens, zabin yanayin na gwamnati da kuma sashi likita dauke akayi daban-daban.

"Endoxan" - kwamfutar hannu - jagora ya bada shawarar sashi 1-3 MG / kg jiki nauyi per day, wadda za ta iya zama daga 50 zuwa 200 MG cyclophosphamide for 24 hours. A tsawon lokaci da magani ne 2-3 makonni.

Idan da miyagun ƙwayoyi ne riƙi tare da sauran kwayoyi da suke da anti-ƙari Properties, da sashi na dukan abubuwa fallasa far gyara.

Shin akwai wani yawan abin sama?

A gaban wani takamaiman maganin guba a cikin shirye-shiryen "endoxane 'umarnin don amfani ba ya tabbatar. A hali na wucewa da ake so kashi shawarar domin tabbatarwa far as dace magani daga cututtuka, janyewar bayyanar cututtuka cardiotoxicity da myelosuppression kawar.

Kamar yadda wani magani da aka hada tare da sauran kwayoyi?

Idan haƙuri daukan wajen sa microsomal hadawan abu da iskar shaka a cikin hanta, sa'an nan da hada magani tare da miyagun ƙwayoyi "endoxan" wa'azi nuna karin kira na metabolites da alkylating aiki, rage rabin-rai na cyclophosphamide da kuma kara ta yadda ya dace.

Wannan magani damuarn cholinesterase aiki da kuma na rayuwa hanya hodar Iblis, kara da yawan guba, da kuma ƙara yadda ya dace da suxamethonium.

Idan "endoxane" amfani a tare da "Allopurinol" cewa akwai aka ƙara bayar da illar kan bargo.

A cikin hali na lokaci daya jiyya da cyclophosphamide, colchicine, probenecid, sulfinpyrazone likita yawanci gyara kashi anti-gout kwayoyi. Wannan ake dangantawa da ƙãra hadarin nephropathy a wani hadin gwiwa aikace-aikace "endoxane" tare da uricosuric kwayoyi.

Cyclophosphamide rage kira dalilai a cikin hanta, ke da alhakin jini clotting da platelet samarwa, duk da haka, yayin da magani tare da anticoagulants rage-rage aiki na karshen.

Marasa lafiya da shan miyagun ƙwayoyi "endoxan" umurci manual bada shawarar a rage cin abinci ban da garehul ruwan 'ya'yan itace, tun da shi ya ƙunshi aka gyara cewa karya kunnawa yadda ya dace da kuma babban aiki sashi daga cikin medicament.

Lokacin da Co-gudanar da cyclophosphamide "Doxorubicin" ko "daunorubicin" an Littafi cardiotoxic sakamakon wadannan kwayoyi.

Hade da sauran immunosuppressants, kamar "Azathioprine" "Tacrolimus", "Chlorambucil", "SSC", "Merkapturin" take kaiwa zuwa wani karuwa a cikin abin da ya faru na sakandare cututtuka da kuma ƙari irin.

A cikin hali na hadin gwiwa amfani "endoxane" da "Lovastina" a marasa lafiya tare da zuciya dasawa iya zama da hadarin rhabdomyolysis da na koda gazawar a wani m form.

Idan magani da cyclophosphamide hade tare mielosupressantami ko da radiation far, yana yiwuwa a sami ugneeniya bargo aiki.

Lokaci daya liyafar "endoxan" tare da high-kashi cytarabine a lokacin shiri jan zuwa bargo dasawa qara faru na m cardiomyopathy.

Ta yaya wannan magani a kan haihuwa aiki?

Drug "endoxane" haƙuri shedu tabbatar da shi, zai iya tsokana sterility a marasa lafiya na biyu mata da maza, wanda zai iya zama babu ja.

A mafi yawan lokuta, mata amenorrhea ya auku, amma hailar tsari yawanci warke cikin 'yan watanni bayan lura da cyclophosphamide. Idan far da aka za'ayi a prepubertal girls, sabawa a ci gaba da sakandare jima'i bayyananen aka lura. Haila ne na al'ada, da takin gargajiya da aka rasa.

A lura da namiji miyagun ƙwayoyi "endoxane" wa'azi ya nuna cewa a wasu lokuta da aka ruwaito azoospermia ko oligospermia. Wannan shi ne saboda da ƙara samar da gonadotropins a wani kudi na testosterone saki. libido matakin da iko a maza ba rage. Idan magani da cyclophosphamide samar a prepubertal boys, da obazovanie sakandare jima'i bayyananen sun faru kullum. Duk da haka, lokuta da azoospermia, oligospermia da kuma kyautata gonadotropins an lura. Yana kuma iya faruwa testicular atrophy. Shi ne ya kamata a lura da cewa azoospermia ne reversible, ko da yake dawo da daga cikin ayyukan na iya faruwa a cikin 'yan shekaru bayan karshen magani.

Mene ne illa na wani magani?

Shan magani "endoxane 'umarnin don amfani da aka tabbatar, da zai iya haddasa wasu cuta daga cikin hemopoietic tsarin:

• Leukopenia, neutropenia - quite sau da yawa.
• Kadan na kowa ne anemia da kuma thrombocytopenia.

Bayan 1-2 makonni daga farkon magani, da mãsu haƙuri nuna matsakaicin akan rage leukocytes da platelets a jini. Wadannan sigogi ake mayar da al'ada a cikin 7-10 kwanaki na karshen far.

A lura da cyclophosphamide iya haifar da gefen halayen na gastrointestinal fili:

• Tashin zuciya da kuma amai.
• Anorekisya.
• Stomatitis.
• Pain a ciki yankin.
• Stool magudi.
• Jaundice.
• Hemorrhagic colitis.

Da wuya faruwa hanta tabarbarewa hade tare da karin ayyuka na enzymes kuma bilirubin matakan tashi. Quite wani babban rukuni na marasa lafiya da suke da aplastic anemia kuma sami high-kashi "endoxane" ko hada shi tare da busulfan, ya ce endoflebit hanta jijiyoyinmu. Wannan sabon abu zai iya faruwa 1-3 makonni bayan bargo dasawa da aka bayyana a cikin wani kaifi karuwa a jikin taro, ascites, hepatomegaly da hyperbilirubinemia, hanta encephalopathy.

Kafin da miyagun ƙwayoyi zai iya sa a ke so halayen da fata:

• Reversible alopecia.
• Kurji.
• A pigmentation na fata da kuma kusoshi.

Yana kuma iya zama jawo by take hakkin da urinary tsarin da magani daga miyagun ƙwayoyi "endoxane". Umurnai, reviews na likitoci da marasa lafiya da ya nuna daban-daban jihohi:

• Cystitis guda biyu tare da fibrosis mafitsara (ko ba tare da shi).
• Hemorrhagic urethritis.
• Necrotic mamaki tubule har mutuwa.

A fitsari, da mãsu haƙuri a iya gano ta epithelium na urinary mafitsara. Idan nau'i na hemorrhagic cystitis nauyi, a daina shan miyagun ƙwayoyi. A mafi kyau rigakafin wannan yanayin ne magani "Mesna". Idan "endoxan" kashi ya karu, zai iya ci gaba koda tabarbarewa kamar yadda nephropathy da giperurekemii.

Idan haƙuri yana da wata azãba mai tsanani mataki na immunosuppression, sa'an nan da magani daga cyclophosphamide iya fuskanci tsanani cututtuka.

Har ila yau, zai iya ci gaba da wadannan illa:

• Cardiotoxicity (high allurai), mai tsanani mataki na zuciya rashin cin nasara.
• Na huhu fibrosis, interstitial yanayi.
• Rushewa daga spermatogenesis da oogenesis, reversible da babu ja sterility.
• A ci gaba da sakandare m neoplasms kamar ciwon daji na mafitsara, mieloproliferatsiya da lymphoproliferation.
• Alerji kamar kurji, itching, urticaria, wani lokacin a cikin nau'i na wani anaphylactic dauki.
• Poor rauni waraka.
• Facial yankin Flushing, sweating, ciwon kai.

A zama na tsanani illa daga shan miyagun ƙwayoyi ne ko da yaushe kiwata tambaya game da yiwu amfanin da wani hadari ga mutum haƙuri.

Wanne cututtuka rubũta wannan magani?

Allunan "endoxan" iya sanya wa haƙuri idan yana da wadannan cututtuka:

• Hodgkin ta cutar.
• Mahara myeloma.
• Nono.
• Lymphoblastic lymphoma a m ko na kullum form.
• Non-Hodgkin ta lymphoma irin.
• Retinoblastoma.
• Neuroblastoma.
• Mycosis gribkovidnogo hali.

Yana nuna karbar na aikace-aikace a cikin hadaddun anticancer far a haɗe zuwa da miyagun ƙwayoyi "endoxane" wa'azi da shi. A manufacturer bada shawarar cewa ita sun hada da a lura da cutar sankarar mahaifa da kuma mafitsara ciwon daji, huhu ciwon daji da kuma prostate ciwon daji, sarcomas da reticulosarcoma, cututtuka Ewing da Wilms.

Da miyagun ƙwayoyi cyclophosphamide-tushen za a iya amfani da a matsayin immunosuppressant m autoimmune cututtuka kamar, psoriatic da rheumatoid amosanin gabbai, haemolytic anemia, collagen cututtuka, nephrotic ciwo, kazalika don kauce wa dasa kin amincewa.

Lokacin da miyagun ƙwayoyi ne contraindicated?

A medicament "endoxan" yana da wani nauyi contraindications, ciki har da:

• Pregnancy kuma lactation.
• Cystitis.
• Cututtuka a aiki form.
• Take hakkin bargo aiki furta form.
• A gaban hypersensitivity ga asali da kuma ƙarin magani abubuwa.
• urinary riƙewa.

Special kula likitoci rubũta da miyagun ƙwayoyi a cututtuka na zuciya, koda da hanta, mai tsanani, gout, adrenalectomy, gaban infiltration matakai a cikin bargo, nefrourolitiaze.

Specific shiriya da magani daga

A lokacin ingestion "endoxan" batun da ya wajaba iko jini (neutrophils da platelet count), kuma fitsari (gaban ja jini Kwayoyin) na mai haƙuri.

shi bada shawarar yanke magani "endoxane" yana nufin a wasu lokuta. Umarnin a kan yin amfani da kwayoyi shawarar yin haka a karkashin wadannan yanayi:

• Bayyanuwar Manuniya cystitis.
• Ragewan da taro na leukocytes da platelets ga m dabi'u.
• Aukuwa kamuwa da cuta (kashi gyara mai yiwuwa ne).

Idan "endoxane" da ake amfani a high allurai, da haƙuri da aka wajabta magani, "Meena" don rigakafin hemorrhagic cystitis irin.

A lura da wannan magani ya kamata dena shan barasa da kuma yin amfani da abin dogara da hanyoyin da maganin hana haihuwa.

Idan haƙuri da ake sa "endoxan" for 10 days bayan tiyata da janar maganin sa barci, da anesthesiologist aka sanar da game da wannan.

Bayan adrenalectomy yi wani kashi gyara "endoxane" da sauran kwayoyi corticosteroids.

miyagun ƙwayoyi analogues

Idan akwai tsanani contraindications da kasada, sa'an nan ya miƙa wa daina shan magani "endoxane" wa'azi da shi. Analogs za a iya wajabta ta likita a matsayin dace madadin. Daga cikin su:

• "Ledoksin".
• "Cyclophosphamide".
• "Cytoxan."
• "Cyclophosphamide - Teva".
• "Cyclophosphamide -Lens".
• "Endoxane - Astana".

Wannan bayani ne mai Saukake version na umarni da miyagun ƙwayoyi "endoxane". Manufar wannan magani aka yi ne kawai da halartar likita.