Rubin peroxidation Lipid (LPO) wani muhimmin hanyar sadarwa ne a cikin metabolism na rayuwa. Babban aikin shi shine sabunta lipids na cell membranes.
A cikin mutum mai lafiya, hanyoyin maganin peroxidation suna sarrafawa ta hanyar da ake kira antioxidant tsarin da yake tsara ƙimar da kuma aiki na phosphorylation ta hanyar haɗakar abubuwan da ke haifarwa ko kuma neutralizing adadin peroxides don hana haɓakaccen kayan samfurori na metabolism. Ƙarfafa tsarin samfur din zai iya zama wuri na farawa a cikin matakai na masu ilimin pathophysiological da yawancin cututtuka. Wannan tsari ya ƙunshi matakai na enzymatic da wadanda ba enzymatic autooxidation.
Iri
Enzymatic oxidation faruwa don gyara da phospholipid bilayer na cell membranes. Bugu da kari, shi ne ake nufi a cikin samuwar ilimin aiki abubuwa, detoxification, rayuwa halayen. Maganin rashin ciwon da ba a ciki ba yana nuna kanta a matsayin mai hallakaswa a cikin rayuwar tantanin halitta. Saboda samuwar babban adadin free radicals da kuma tara na peroxides, aikin na antioxidant tsarin ragewa kuma, a sakamakon haka, mutuwar cell mutu.
LPO sake zagayowar
Ga farkon jigilar maganin lipid, kasancewa a cikin nauyin yaduwar oxygen kyauta, yana da matsananciyar matakan makamashi wanda ba a biya shi ba, ya zama dole. Bayan sun dawo da kwayoyin, an kafa magudanin oxygen, wanda ya hada da hydrogen atomes, juya zuwa hydrogen peroxide. Don sarrafa adadin superoxide a cikin tantanin halitta, akwai alamar rashin ƙarfi, wadda take samar da hydrogen peroxide, da kuma catalase kuma peroxidase ya daidaita shi zuwa ruwa. Idan wani kwayar halitta mai rai ya fallasa shi zuwa radiation radiation, yawan adadin hydroxyl na kyauta zai kara ƙaruwa sosai. Bugu da ƙari, oxygen hydroxide da sauran siffofi masu aiki zasu iya aiki a matsayin masu ƙaddamar da tsarin maganin lipid peroxidation.
Ana amfani da samfurori na maganin lipid ta jiki ko amfani dashi don kira prostaglandins (abubuwan da ke cikin halayen ƙin ƙwayoyin cuta), thromboxanes (sun hada da maganin halayen thrombus-forming), hormones adrenal.
Sarrafa tsarin
Dangane da tsarin asalin tantanin halitta, ƙimar, aiki da adadin samfurorin samfurori da aka samu zasu iya bambanta. Alal misali, na ayyuka na lipids peroxidation sama inda wani ɓangare na cell bango aka mamaye unsaturated m acid, da kuma hankali, idan tushen da Cop ne cholesterol. Bugu da ƙari, ƙwayoyin enzymes na rayuwa sune mahimmanci da ke tsara yawan adadin da aka samu na samfurori na oxygen, da kuma amfani da peroxides. Koda a cikin maganin lipid peroxidation, abubuwa da zasu shafi nauyin lipid na cell membrane da sabuntawar sabani daidai da bukatun kwayoyin keyi. Wadannan sun hada da bitamin E da K, thyroxine (thyroid hormone), hydrocortisone, cortisone da aldosterone (a kan tsarin feedback). Kwanonin karfe, bitamin C da D. suna satar tantanin tantanin halitta.
Tsarin Tsarin
Hanyoyi masu amfani da lipid peroxidation zasu iya tarawa a cikin kyallen takarda da kuma ruwan jiki idan tsarin antioxidant bai iya sarrafa su ba a farashin da ake bukata. A sakamakon haka, hawa mai amfani ta jikin kwayar halitta ta rushe shi, wanda a kaikaice zai iya rinjayar abun da ke ciki na kwayar ruwa na jini, ladabi na ladabi da kuma lalata gawar jikin ƙwayoyin tsohuwar jiki (rushe halayen halayen kwakwalwa, kwangilar su, ƙãra lokacin da ya ɓata), ya inganta saurin gudu zuwa cikin sararin samaniya (edema, Sanin jini, cin zarafin auna). Bugu da kari, babban kayayyakin na sia peroxidation, bayan jerin biochemical halayen, ana tuba zuwa aldehydes, ketones, acid da sauransu. Wadannan abubuwa suna da wani mai guba sakamako a kan jikin, wanda bayyana kanta a rage kudi na DNA kira, kara capillary permeability, kara oncotic matsa lamba, kamar yadda Sakamakon, sutge-syndrome.
Bayani a cikin asibiti
Tun da karuwa a yawan adadin oxygen radicals yana da tasiri akan rufin tantanin halitta, kuma samfurori na zamani sun rushe metabolism da kuma kira na nucleic acid, kuma suna shafe jiki, sune magungunan ilimin likitanci a ci gaba da yawan yanayin asibiti. Matsayi na lipid peroxidation yana da mahimmanci ga cututtuka na hanta, mahaukaci, cututtuka na parasitic, cututtukan hemodynamic, cututtuka masu ilimin halittu, raunuka da konewa. LPO yana daya daga cikin dalilai a ci gaban atherosclerosis. Sakamakon yaduwar kwayoyin cutar, cholesterol oxidizing da ɓangaren ƙananan nauyin kwayoyin halitta, samar da samfurori da zasu lalata katako. A wannan yanayin, ana haifar da halayen halayen dabi'a wanda ake nufi da kawar da lalacewa. Wannan ya haifar da thrombosis, tarawa da jini a cikin lumen kananan jiragen ruwa ko abin da aka makala ga ganuwar. A sakamakon haka, yunkurin jini a wannan yanki ya ragu, saboda lumen na jirgin ya riga ya zama. Wannan yana taimakawa wajen kara haɗin jini. A mafi saukin kamuwa da irin wannan canje-canje a cikin jijiyoyin zuciya arteries, da lakã, bayyana a cikin asibitin cututtuka na jijiyoyin zuciya cuta na zuciya.
Tsarin kariya
Dole ne likitoci su tuna da cewa aiwatar da bincike da kuma hanyoyin maganin za su iya aiki da nau'in maganin lipid peroxidation. Wannan ya kamata a gargadi masu haƙuri. By sa dalilai sun hada da radiation far (for ciwon daji), ultraviolet da haske (tare da rickets, kumburi cututtuka na sinuses, antibacterial jiyya dakuna), Magnetic filayen (MRI, CT, jiki far) zaman a wani hyperbaric jam'iyya (a poliomyelitis, tsawo amai).
Rigakafin da farfadowa
Masu aiki a cikin dakunan rayuka, masu jinya da ma'aikatan jinya, likitocin aikin likita, masu hawa, mutane da nauyin nauyi sun ci abincin da ke dauke da antioxidants na halitta: kifi, sunflower ko man zaitun, ganye, qwai, koren shayi. Baya ga canza abincin, yana yiwuwa a yi amfani da kwayoyi wanda ke ɗaure wasu kungiyoyin kyauta marasa kyauta ko hada tare da ƙwayoyin miki. Saboda haka, sun maye gurbin kwayoyin halitta marasa amfani na oxygen, ba tare da izinin su su ɗaure masu ƙarfin LPO ba.
Diagnostics
A halin yanzu na ci gaban nazarin gwaje-gwaje, mun sami damar gano peroxides a cikin abun da ke ciki na ruhu na jikin mutum. Don yin wannan, gudanar da wani haske bincike da madubin likita. Kawai sanya, don gano lipid peroxidation. Muhimmancin gwajin gwaji ba ya buƙatar bayani. Bayan haka, dalilin mahimmin adadin cututtuka shine kima da yawa na lipid peroxidation. Ƙididdigar wannan yanayin yana ƙayyade mahimmancin magani.
Ta fuskar al'ada Physiology na sia peroxidation wajibi ne ga samuwar steroid hormones, kumburi shiga tsakani, cytokines da thromboxanes. Amma idan adadin samfurori na sinadaran musayar bayanai ya wuce adadin halatta kuma peroxides ya lalata kwayoyin halitta, rushe kira na DNA da sunadarai, tsarin tsarin antioxidant wanda ya rage adadin sassan oxygen, kyauta mai nauyin karfe tare da mai sauƙi ya shiga aiki. Bugu da ƙari, yana ƙara kira na catalase da peroxidase domin amfani da ragi na peroxides da samfurori na kara ci gaban metabolism.