Ƙari Necrosis Factor: shirye-shirye

Ƙari necrosis factor (TNF) - wani rukuni na cytokines takamaiman gina jiki - hormone-kamar abubuwa samar da rigakafi da tsarin. Ana sa da yawa ban sha'awa a cikin magani saboda da kaddarorin - ikon sa cell mutuwa (necrosis) intratumoral nama. Wannan ne ainihin nasara a magani, kyale ka ka nema kayayyakin da TNF domin lura da ciwon daji.

Tarihi na samu

By farkon XX karni a likita yi an gano juna: a wasu marasa lafiya akwai wani karu da / ko bacewar ƙari samuwar bayan da canja wurin da wani kamuwa da cuta. Sa'an nan American masanin William Coley fara da gangan gudanar da magungunan cutar daji dauke da cututtuka gida (kwayoyin da su gubobi). A Hanyar aka iske ba ya zama tasiri, kamar yadda yana da karfi da mai guba sakamako a kan haƙuri. Amma shi shi ne farkon mai yawan bincike da zai kai ga gano mai gina jiki, da ake kira da ƙari necrosis factor. Found abu haddasa m mutuwa da ciwon daji Kwayoyin shukakkun karkashin fata na gwaji beraye. A kadan daga baya, shi da aka ware tsarki TNF, wanda a yarda a yi amfani da shi domin gudanar da bincike dalilai.

Wannan samu gudummawar nasara a ciwon daji far. A baya can, ta amfani da sunadarai cytokines iya samu nasarar yi wa ciwon daji ne kawai 'yan of Education - melanoma fata ciwon daji, koda ciwon daji. Duk da haka, wani gagarumin ci gaba a cikin wannan filin da ya yarda da nazarin Properties mallaki by ƙari necrosis factor. Shirye-shirye dangane da shi suna kunshe a cikin jiyyar cutar sankara hanya.

inji na mataki

ƙari necrosis factor abubuwa a kan wani takamaiman cell - manufa. Akwai da dama sunadaran da mataki:

• Ta hanyar musamman TNF rabe gabatar da Multi-mataki inji - kaddara cell mutuwa (apoptosis). Wannan mataki da aka kira wani cytotoxic. A lokaci guda kiyaye cikakken bacewar marurai, ko rage girman.
• Ta hanyar warwarewarsu ko ƙarshe na cell sake zagayowar. Cancer cell zama kasa raba da ƙari girma da aka tsaya. Wannan mataki da aka kira wani cytostatic. Yawanci busa a cikinsa ko dai tsaya a nan karuwa ne, ko ragewa a cikin size.
• By tarewa da samuwar tsari na neovascularization ƙari nama da kuma lalacewar pre-data kasance capillaries. A ƙari da aka hana na abinci, necrotic, tayi vuya.

Akwai yanayi inda da ciwon daji Kwayoyin ne m ga allura miyagun ƙwayoyi saboda maye gurbi. Sa'an nan sama da sunadaran ba bayyana.

A amfani a magani

Ƙari necrosis factor da ake amfani a cikin abin da ake kira Cytokine far - magani daga takamaiman sunadaran da aka generated da jini Kwayoyin alhakin rigakafi. Hanya ne zai yiwu a kowane mataki na da ƙari aiwatar da ba contraindicated ga mutanen da tare comorbidities - zuciya da jijiyoyin jini, koda, hanta. Don rage yawan guba amfani shafa recombination ƙari necrosis factor.

Jiyya tare cytokines - sabon da kuma gaba da bunkasa fannin Oncology. A amfani da TNF yana dauke da mafi inganci. Tun da yake wannan abu ne mai matuƙar mai guba, shi ne amfani da abin da ake kira yankin perfusion. A Hanyar kunshi a gaskiyar cewa kamuwa da ciwon daji sashin jiki ko jiki sashi da taimako na musamman kayan aiki ceto daga cikin janar wurare dabam dabam. Sa'an nan artificially fararwa jini wurare dabam dabam tare da allura TNF.

m sakamakon

A asibiti yi, ƙari necrosis factor amfani da hankali. A yawan nazarin tabbatar da cewa TNF - a key bangaren a gaban sepsis, mai guba buga. A gaban wannan sunadari ya karu da pathogenicity na kwayan da kwayar cututtuka, wanda shi ne musamman m, a gaban HIV a wani haƙuri. Yana tabbatar da cewa TNF ne da hannu a haddasa autoimmune cututtuka (msl, rheumatoid amosanin gabbai) a cikin abin da na rigakafi da tsarin kuskure na'am da kyallen takarda da Kwayoyin da kwayoyin na waje jikinsu da kuma diyya su.

Don rage girman high mai guba sakamako tsayar da wadannan matakan:

• amfani ne kawai a gida a shafin na ƙari samuwar.
• hada da sauran kwayoyi.
• Sun yi aiki tare da kasa mai guba mutant TNF sunadaran.
• gudanar neutralizing antibodies.

Wadannan al'amura tilasta iyakance amfani da ƙari necrosis factor. Jiyya ya kamata su zama da tsari sosai.

diagnostic nuna alama

A jini gwajin ba ya gane TNF a wani lafiya jiki. Amma ta matakin qara da cika fuska a cututtuka inda jini zo pathogen gubobi. To, yana iya zama ba a cikin fitsari. Ƙari necrosis factor a cikin synovial ruwa na rheumatoid amosanin gabbai ce.

Har ila yau kara da wannan nuna alama yayi magana akan rashin lafiyan halayen, ciwon daji da kuma cututtuka ne da wata ãyã daga kin amincewa da transplanted bayarwa gabobin. Akwai shaida da cewa da karuwa a cikin wannan nuna alama iya nuna cewa ba communicable cututtuka irin su zuciya rashin cin nasara, Bronchial asma.

A daban-daban immunodeficiency (ciki har da AIDS), kuma mai tsanani kwayar cututtuka da ke faruwa, kazalika da raunin da konewa, yanayi da ake halitta wadda rage ƙari necrosis factor. A miyagun ƙwayoyi wanda yana da wani immunosuppressive sakamako, ba a irin wannan sakamako.

shirye-shirye

dangane TNF kwayoyi kira niyya - ikon aiki da saiti a takamaiman kwayoyin ciwon daji Kwayoyin, haddasa mutuwar Malkisadik. A sakamako a kan sauran gabobin ne kadan, wanda rage yawan guba, wanda yana da wani ƙari necrosis factor. tushen kwayoyi suna amfani da wani TNF kadai (monotherapy) da kuma hada da sauran jamiái.

Yau, akwai da dama da kayayyakin a kan tushen da TNF, wato:

• NGR-TNF - waje samfurin, da aiki sashi ne wanda aka samu daga cikin TNF. Shi ne iya lalata jini na ƙari, ya tauye shi na da iko.
• "Alnorin" - Rasha ci gaba. Yana da matuƙar tasiri a hade tare da interferons.

"Refnot" - Rasha ta sabon maganin dauke da ƙari necrosis factor da thymosin alpha 1. Its yawan guba ne ragu, amma ya dace shi ne daidai da na halitta TNF, kuma ko da ya wuce shi da wani immunostimulatory mataki. Da miyagun ƙwayoyi da aka halitta, a 1990. An samu nasarar wuce duk dole gwajinsu da kawai a shekarar 2009 da aka rubuta, wanda ya ba da hukuma izinin bi da su da sankara.

Kai gwamnati na duk kwayoyi a kan tushen da ƙari necrosis factor cikakken haramta. Ciwon daji magani - sosai tsari tsari da yake faruwa na musamman a karkashin kulawa da wani gwani.